| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (600 mg/kg) (for 13 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
67.0 days-74.0 days |
5 |
132.1 |
um |
3.18 |
7.1 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105477 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
vehicle control condition (0 mg/kg) (for 13 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
67.0 days-74.0 days |
5 |
138.5 |
um |
3.4 |
7.6 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105474 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (10 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
111.0 days-118.0 days |
5 |
134.2 |
um |
4.79 |
10.7 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105491 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (10 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
136.0 days-143.0 days |
5 |
128.2 |
um |
3.8 |
8.5 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105499 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (100 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
136.0 days-143.0 days |
5 |
124.3 |
um |
3.44 |
7.7 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105500 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
vehicle control condition (0 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
142.2 |
um |
2.68 |
6.0 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105466 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (100 mg/kg) (for 13 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
67.0 days-74.0 days |
5 |
138.9 |
um |
3.49 |
7.8 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105476 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
vehicle control condition (0 mg/kg) (for 26 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
80.0 days-87.0 days |
10 |
136.0 |
um |
3.49 |
7.8 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105482 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (100 mg/kg) (for 26 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
80.0 days-87.0 days |
10 |
138.5 |
um |
4.25 |
9.5 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105484 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (600 mg/kg) (for 26 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
80.0 days-87.0 days |
10 |
133.4 |
um |
3.04 |
6.8 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105485 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (100 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
111.0 days-118.0 days |
5 |
128.1 |
um |
3.49 |
7.8 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105492 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (600 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
136.0 days-143.0 days |
5 |
112.7 |
um |
2.91 |
6.5 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105501 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (600 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
132.4 |
um |
3.44 |
7.7 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105469 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (10 mg/kg) (for 26 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
80.0 days-87.0 days |
10 |
137.0 |
um |
3.44 |
7.7 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105483 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
vehicle control condition (0 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
136.0 days-143.0 days |
5 |
129.8 |
um |
4.02 |
9.0 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105498 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (10 mg/kg) (for 13 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
67.0 days-74.0 days |
5 |
138.8 |
um |
3.67 |
8.2 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105475 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (600 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
111.0 days-118.0 days |
5 |
118.6 |
um |
3.35 |
7.5 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105493 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (100 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
134.5 |
um |
3.35 |
7.5 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105468 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
AMG-8718 (10 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
140.0 |
um |
3.22 |
7.2 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105467 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
vehicle control condition (0 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
111.0 days-118.0 days |
5 |
132.2 |
um |
3.71 |
8.3 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105490 |
3016 |