| ACI/Eur |
kidney sclerotic glomeruli count to total glomeruli count ratio |
unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) |
Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. |
kidney glomerulus integrity trait |
male |
173.0 days-180.0 days |
11 |
|
13.0 |
% |
2.0 |
6.63 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
|
67959 |
751 |
| ACI/Eur |
kidney sclerotic glomeruli count to total glomeruli count ratio |
controlled hydrogen ion content drinking water (2.4-2.8 pH) |
Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. |
kidney glomerulus integrity trait |
male |
98.0 days
| 15 |
|
6.0 |
% |
1.0 |
3.87 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
|
68044 |
751 |
| FHH/Eur |
kidney sclerotic glomeruli count to total glomeruli count ratio |
controlled hydrogen ion content drinking water (2.4-2.8 pH) |
Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. |
kidney glomerulus integrity trait |
male |
98.0 days
| 15 |
|
13.0 |
% |
1.0 |
3.87 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
|
68046 |
751 |
| ACI.FHH-(D1Rat324-D1Rat156)/Eur |
kidney sclerotic glomeruli count to total glomeruli count ratio |
controlled hydrogen ion content drinking water (2.4-2.8 pH) |
Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. |
kidney glomerulus integrity trait |
male |
98.0 days
| 18 |
|
10.0 |
% |
1.0 |
4.24 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
|
68047 |
751 |
| SD |
kidney sclerotic glomeruli count to total glomeruli count ratio |
unilateral nephrectomy (for 28 days) then spironolactone (5.56 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney glomerulus integrity trait |
male |
days
| 8 |
|
26.0 |
% |
3.89 |
11.0 |
ex vivo light microscopy with histochemistry |
|
0.0 |
unx |
28 |
days |
|
101630 |
2602 |
| MWF/Ztm |
kidney sclerotic glomeruli count to total glomeruli count ratio |
standard diet |
Remuzzi A, etal., Am J Kidney Dis. 1999 Oct;34(4):626-32. doi: 10.1016/S0272-6386(99)70385-9. |
kidney glomerulus integrity trait |
male |
140.0 days
| 8 |
median |
2.2 |
% |
|
|
ex vivo light microscopy with histochemistry |
left kidney |
0.0 |
|
|
|
|
109985 |
3162 |
| SD |
kidney sclerotic glomeruli count to total glomeruli count ratio |
sham surgical control condition (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney glomerulus integrity trait |
male |
days
| 6 |
|
1.9 |
% |
0.49 |
1.2 |
ex vivo light microscopy with histochemistry |
|
0.0 |
sham unx |
28 |
days |
|
101603 |
2602 |
| SD |
kidney sclerotic glomeruli count to total glomeruli count ratio |
unilateral nephrectomy (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney glomerulus integrity trait |
male |
days
| 7 |
|
37.2 |
% |
10.02 |
26.5 |
ex vivo light microscopy with histochemistry |
|
0.0 |
unx |
28 |
days |
|
101604 |
2602 |
| SHR/N-cp |
kidney sclerotic glomeruli count to total glomeruli count ratio |
standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then controlled hydralazine content drinking water (30 mg/l) (between 84 and 98 days) and hydralazine (50 mg/l) (between 84 and 98 days) and reserpine (4 mg/l) (between 84 and 98 days) |
Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. |
kidney glomerulus integrity trait |
male |
140.0 days-168.0 days |
8 |
|
4.0 |
% |
1.0 |
2.83 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
|
101528 |
2601 |
| ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur |
kidney sclerotic glomeruli count to total glomeruli count ratio |
controlled NG-nitroarginine methyl ester content in acidified drinking water (8-13 mg/kg/d) (for 126 days) |
Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. |
kidney glomerulus integrity trait |
male |
173.0 days-180.0 days |
9 |
|
5.0 |
% |
6.0 |
18.0 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
|
67954 |
751 |
| ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur |
kidney sclerotic glomeruli count to total glomeruli count ratio |
controlled hydrogen ion content drinking water (2.4-2.8 pH) |
Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. |
kidney glomerulus integrity trait |
male |
98.0 days
| 15 |
|
5.0 |
% |
1.0 |
3.87 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
|
68045 |
751 |
| SD |
kidney sclerotic glomeruli count to total glomeruli count ratio |
unilateral nephrectomy (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney glomerulus integrity trait |
male |
days
| 8 |
|
31.0 |
% |
5.66 |
16.0 |
ex vivo light microscopy with histochemistry |
|
0.0 |
unx |
28 |
days |
|
101629 |
2602 |
| SD |
kidney sclerotic glomeruli count to total glomeruli count ratio |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) and aldosterone (35 mg/kg/d) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney glomerulus integrity trait |
male |
days
| 6 |
|
25.3 |
% |
4.53 |
11.1 |
ex vivo light microscopy with histochemistry |
|
0.0 |
unx |
28 |
days |
|
101606 |
2602 |
| ACI/Eur |
kidney sclerotic glomeruli count to total glomeruli count ratio |
controlled NG-nitroarginine methyl ester content in acidified drinking water (8-13 mg/kg/d) (for 126 days) |
Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. |
kidney glomerulus integrity trait |
male |
173.0 days-180.0 days |
8 |
|
6.0 |
% |
2.0 |
5.66 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
|
67953 |
751 |
| ACI.FHH-(D1Rat324-D1Rat156)/Eur |
kidney sclerotic glomeruli count to total glomeruli count ratio |
unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) |
Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. |
kidney glomerulus integrity trait |
male |
173.0 days-180.0 days |
8 |
|
41.0 |
% |
9.0 |
25.46 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
% glomerulosclerosis |
67961 |
751 |
| SD |
kidney sclerotic glomeruli count to total glomeruli count ratio |
unilateral nephrectomy (for 28 days) then enalapril (50 mg/l) (for 28 days) and losartan (180 mg/l) (for 28 days) |
Greene EL, et al., J Clin Invest. 1996 Aug 15;98(4):1063-8. |
kidney glomerulus integrity trait |
male |
days
| 7 |
|
4.7 |
% |
1.97 |
5.2 |
ex vivo light microscopy with histochemistry |
|
0.0 |
unx |
28 |
days |
|
101605 |
2602 |
| MWF/Ztm |
kidney sclerotic glomeruli count to total glomeruli count ratio |
standard diet |
Remuzzi A, etal., Am J Kidney Dis. 1999 Oct;34(4):626-32. doi: 10.1016/S0272-6386(99)70385-9. |
kidney glomerulus integrity trait |
male |
210.0 days
| 10 |
median |
18.6 |
% |
|
|
ex vivo light microscopy with histochemistry |
left kidney |
0.0 |
|
|
|
|
109986 |
3162 |
| MWF/Ztm |
kidney sclerotic glomeruli count to total glomeruli count ratio |
controlled lisinopril content drinking water (50 mg/l) (for 70 days) |
Remuzzi A, etal., Am J Kidney Dis. 1999 Oct;34(4):626-32. doi: 10.1016/S0272-6386(99)70385-9. |
kidney glomerulus integrity trait |
male |
210.0 days
| 7 |
median |
2.6 |
% |
|
|
ex vivo light microscopy with histochemistry |
left kidney |
0.0 |
|
|
|
|
109987 |
3162 |
| ACI.FHH-(D1Rat324-D1Rat156)/Eur |
kidney sclerotic glomeruli count to total glomeruli count ratio |
controlled NG-nitroarginine methyl ester content in acidified drinking water (8-13 mg/kg/d) (for 126 days) |
Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. |
kidney glomerulus integrity trait |
male |
173.0 days-180.0 days |
7 |
|
16.0 |
% |
5.0 |
13.23 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
|
67955 |
751 |
| ACI/Eur |
kidney sclerotic glomeruli count to total glomeruli count ratio |
unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) |
Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. |
kidney glomerulus integrity trait |
male |
173.0 days-180.0 days |
8 |
|
5.0 |
% |
1.0 |
2.83 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
|
67956 |
751 |
| ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur |
kidney sclerotic glomeruli count to total glomeruli count ratio |
unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) |
Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. |
kidney glomerulus integrity trait |
male |
173.0 days-180.0 days |
10 |
|
2.0 |
% |
1.0 |
3.16 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
|
67957 |
751 |
| ACI.FHH-(D1Rat324-D1Rat156)/Eur |
kidney sclerotic glomeruli count to total glomeruli count ratio |
unilateral nephrectomy then controlled hydrogen ion content drinking water (2.4-2.8 pH) |
Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. |
kidney glomerulus integrity trait |
male |
173.0 days-180.0 days |
8 |
|
9.0 |
% |
3.0 |
8.49 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
|
67958 |
751 |
| ACI.FHH-(D17Rat117-D17Arb5)(D17Rat180-D17Rat51)/Eur |
kidney sclerotic glomeruli count to total glomeruli count ratio |
unilateral nephrectomy then controlled NG-nitroarginine methyl ester content in acidified drinking water (11-15 mg/kg/d) (for 126 days) |
Van Dijk SJ, et al., Nephron Exp Nephrol 2005 Jun 20;101(2):e59-e66. |
kidney glomerulus integrity trait |
male |
173.0 days-180.0 days |
9 |
|
8.0 |
% |
2.0 |
6.0 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
|
67960 |
751 |
| SHR/N-cp |
kidney sclerotic glomeruli count to total glomeruli count ratio |
standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) |
Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. |
kidney glomerulus integrity trait |
male |
168.0 days-196.0 days |
8 |
|
16.0 |
% |
3.0 |
8.49 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
|
101526 |
2601 |
| SHR/N-cp |
kidney sclerotic glomeruli count to total glomeruli count ratio |
standard diet (between 28 and 42 days) then controlled carbohydrate content diet (54 %) (between 140 and 154 days) then perindopril (0.25-0.5 mg/kg/d) (between 84 and 98 days) |
Velasquez MT, et al., Hypertension. 1997 Nov;30(5):1232-7. |
kidney glomerulus integrity trait |
male |
168.0 days-196.0 days |
8 |
|
9.0 |
% |
4.0 |
11.31 |
ex vivo light microscopy with histochemistry |
|
0.0 |
|
|
|
|
101527 |
2601 |