| F344 |
number of abdominal retractions |
Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 7 |
57.75 |
null |
27.0 |
71.44 |
visual assessment of in vivo video recording |
1500.0 |
|
|
|
|
stretch/retract abdomon |
105551 |
3018 |
| F344 |
number of abdominal retractions |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
10.66 |
null |
5.4 |
10.8 |
visual assessment of in vivo video recording |
1500.0 |
|
|
|
|
stretch/retract abdomon |
105559 |
3018 |
| F344 |
number of abdominal retractions |
sucrose (10 %) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
82.5 |
null |
12.22 |
21.17 |
visual assessment of in vivo video recording |
1500.0 |
|
|
|
|
retract abdomen |
105562 |
3018 |
| F344 |
mean arterial blood pressure |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/kg) (for 1 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
arterial blood pressure trait |
male |
days
| 3 |
98.16 |
mmHg |
|
|
unspecified method |
0.0 |
|
|
|
|
|
105573 |
3018 |
| F344 |
ventricular late potential |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/g) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart electrical impulse conduction trait |
male |
days
| 3 |
0.86 |
% |
0.21 |
0.36 |
electrocardiography |
0.0 |
|
|
|
|
CV% |
105580 |
3018 |
| F344 |
cerebrum infarct volume to total cerebrum volume ratio |
isoflurane (1.5 %) (for 4 hours) then rolipram (3 mg/kg) then middle cerebral artery occlusion (for 1 hours) |
Yang F, et al., J Pharm Pharm Sci. 2014;17(3):362-70. |
cerebrum integrity trait |
male |
days
| 18 |
25.0 |
% |
3.0 |
12.73 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
cerebral ischemia |
1 |
days |
|
|
106195 |
3029 |
| F344 |
number of lower body licking events |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
2.0 |
null |
2.0 |
4.0 |
visual assessment of in vivo video recording |
1500.0 |
|
|
|
|
number of lower body licking events |
105556 |
3018 |
| F344 |
number of lower body licking events |
sucrose (10 %) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 3 |
58.0 |
null |
12.92 |
22.38 |
visual assessment of in vivo video recording |
1500.0 |
|
|
|
|
lower body licking event |
105560 |
3018 |
| F344 |
number of lower body licking events |
4-methyl-2-(piperidin-1-yl)-quinoline (0.75 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 3 |
19.25 |
null |
7.19 |
12.45 |
visual assessment of in vivo video recording |
1500.0 |
|
|
|
|
lower body licking event |
105561 |
3018 |
| F344 |
mean arterial blood pressure |
control condition |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
arterial blood pressure trait |
male |
days
| 2 |
111.04 |
mmHg |
|
|
unspecified method |
0.0 |
|
|
|
|
|
105568 |
3018 |
| F344 |
mean arterial blood pressure |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/kg) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
arterial blood pressure trait |
male |
days
| 3 |
120.97 |
mmHg |
|
|
unspecified method |
0.0 |
|
|
|
|
|
105571 |
3018 |
| F344 |
measurement of the 50% threshold of mechanical stimulus needed to elicit evasive reaction |
4-methyl-2-(piperidin-1-yl)-quinoline (0.75 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 null) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
tactile sensory behavior trait |
male |
days
| 4 |
14.77 |
g |
2.3 |
4.6 |
von Frey assay |
1500.0 |
|
|
|
von Frey assay (MMO:0000752) |
both paws |
105567 |
3018 |
| F344 |
ST interval |
control condition |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart electrical impulse conduction trait |
male |
days
| 3 |
53.73 |
ms |
3.65 |
6.32 |
electrocardiography |
0.0 |
|
|
|
|
|
105590 |
3018 |
| F344 |
number of abdominal retractions |
4-methyl-2-(piperidin-1-yl)-quinoline (0.5 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
31.67 |
null |
2.18 |
4.36 |
visual assessment of in vivo video recording |
1500.0 |
|
|
|
|
stretch/retract abdomon |
105558 |
3018 |
| F344 |
number of lower body licking events |
4-methyl-2-(piperidin-1-yl)-quinoline (0.5 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
21.67 |
null |
4.9 |
9.8 |
visual assessment of in vivo video recording |
1500.0 |
|
|
|
|
lower body licking event |
105555 |
3018 |
| F344 |
mean arterial blood pressure |
sucrose (10 %) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
arterial blood pressure trait |
male |
days
| 2 |
123.56 |
mmHg |
|
|
unspecified method |
0.0 |
|
|
|
|
|
105570 |
3018 |
| F344 |
heart rate |
control condition |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart pumping trait |
male |
days
| 3 |
449.89 |
beats/min |
16.8 |
29.1 |
electrocardiography |
0.0 |
|
|
|
|
|
105574 |
3018 |
| F344 |
PR interval |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/g) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart electrical impulse conduction trait |
male |
days
| 3 |
29.6 |
ms |
0.28 |
0.48 |
electrocardiography |
0.0 |
|
|
|
|
pq interval |
105584 |
3018 |
| F344 |
QRS duration |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/g) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart electrical impulse conduction trait |
male |
days
| 3 |
15.41 |
ms |
0.56 |
0.97 |
electrocardiography |
0.0 |
|
|
|
|
pq interval |
105588 |
3018 |
| F344 |
QT interval |
control condition |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart electrical impulse conduction trait |
male |
days
| 3 |
68.11 |
ms |
4.56 |
7.9 |
electrocardiography |
0.0 |
|
|
|
|
|
105594 |
3018 |
| F344 |
cerebrum infarct volume to total cerebrum volume ratio |
isoflurane (1.5 %) (for 4 hours) then vehicle control condition then middle cerebral artery occlusion (for 1 hours) |
Yang F, et al., J Pharm Pharm Sci. 2014;17(3):362-70. |
cerebrum integrity trait |
male |
days
| 18 |
11.0 |
% |
2.0 |
8.49 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
cerebral ischemia |
1 |
days |
|
|
106172 |
3029 |
| F344 |
cerebrum infarct volume to total cerebrum volume ratio |
isoflurane (1.5 %) (for 4 hours) then vehicle control condition then middle cerebral artery occlusion (for 1 hours) |
Yang F, et al., J Pharm Pharm Sci. 2014;17(3):362-70. |
cerebrum integrity trait |
male |
days
| 6 |
18.0 |
% |
6.0 |
14.7 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
cerebral ischemia |
1 |
days |
|
|
106361 |
3029 |
| F344 |
measurement of the 50% threshold of mechanical stimulus needed to elicit evasive reaction |
4-methyl-2-(piperidin-1-yl)-quinoline (0.15 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
tactile sensory behavior trait |
male |
days
| 4 |
11.35 |
g |
1.62 |
3.24 |
von Frey assay |
1500.0 |
|
|
|
von Frey assay (MMO:0000752) |
right paw |
109702 |
3018 |
| F344 |
number of abdominal retractions |
4-methyl-2-(piperidin-1-yl)-quinoline (0.75 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
32.5 |
null |
9.26 |
16.04 |
visual assessment of in vivo video recording |
1500.0 |
|
|
|
|
retract abdomen |
105563 |
3018 |
| F344 |
measurement of the 50% threshold of mechanical stimulus needed to elicit evasive reaction |
sucrose (10 %) (for 0.5 hours) then Allyl isothiocyanate (0.5 null) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
tactile sensory behavior trait |
male |
days
| 4 |
2.88 |
g |
0.44 |
0.88 |
von Frey assay |
1500.0 |
|
|
|
von Frey assay (MMO:0000752) |
both paws |
105566 |
3018 |
| F344 |
heart rate |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/kg) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart pumping trait |
male |
days
| 3 |
424.89 |
beats/min |
2.65 |
4.59 |
electrocardiography |
0.0 |
|
|
|
|
|
105576 |
3018 |
| F344 |
ventricular late potential |
control condition |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart electrical impulse conduction trait |
male |
days
| 3 |
1.29 |
% |
0.14 |
0.24 |
electrocardiography |
0.0 |
|
|
|
|
CV% |
105578 |
3018 |
| F344 |
QT interval |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/g) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart electrical impulse conduction trait |
male |
days
| 3 |
72.02 |
ms |
1.68 |
2.91 |
electrocardiography |
0.0 |
|
|
|
|
|
105596 |
3018 |
| F344 |
measurement of the 50% threshold of mechanical stimulus needed to elicit evasive reaction |
4-methyl-2-(piperidin-1-yl)-quinoline (0.15 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
tactile sensory behavior trait |
male |
days
| 4 |
10.85 |
g |
0.78 |
1.56 |
von Frey assay |
1500.0 |
|
|
|
von Frey assay (MMO:0000752) |
left paw |
109701 |
3018 |
| F344 |
number of lower body licking events |
Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 7 |
49.75 |
null |
4.5 |
11.91 |
visual assessment of in vivo video recording |
1500.0 |
|
|
|
|
lower body licking event |
105548 |
3018 |
| F344 |
number of lower body licking events |
sucrose (10 %) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
52.14 |
null |
7.27 |
14.54 |
visual assessment of in vivo video recording |
1500.0 |
|
|
|
|
lower body licking event |
105554 |
3018 |
| F344 |
number of abdominal retractions |
sucrose (10 %) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
68.28 |
null |
16.67 |
33.34 |
visual assessment of in vivo video recording |
1500.0 |
|
|
|
|
stretch/retract abdomon |
105557 |
3018 |
| F344 |
number of lower body licking events |
sucrose (10 %) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
58.0 |
null |
7.27 |
12.92 |
visual assessment of in vivo video recording |
1500.0 |
|
|
|
|
licking abdomen events |
105564 |
3018 |
| F344 |
number of lower body licking events |
4-methyl-2-(piperidin-1-yl)-quinoline (0.75 mg/kg) (for 0.5 hours) then Allyl isothiocyanate (0.5 %) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
chemical nociception trait |
male |
days
| 4 |
19.25 |
null |
4.9 |
7.19 |
visual assessment of in vivo video recording |
1500.0 |
|
|
|
|
licking abdomen events |
105565 |
3018 |
| F344 |
mean arterial blood pressure |
control condition |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
arterial blood pressure trait |
male |
days
| 3 |
113.42 |
mmHg |
|
|
unspecified method |
0.0 |
|
|
|
|
|
105569 |
3018 |
| F344 |
mean arterial blood pressure |
sucrose (10 %) (for 1 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
arterial blood pressure trait |
male |
days
| 2 |
127.7 |
mmHg |
|
|
unspecified method |
0.0 |
|
|
|
|
|
105572 |
3018 |
| F344 |
PR interval |
control condition |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart electrical impulse conduction trait |
male |
days
| 3 |
28.92 |
ms |
1.54 |
2.67 |
electrocardiography |
0.0 |
|
|
|
|
pq |
105582 |
3018 |
| F344 |
QRS duration |
control condition |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart electrical impulse conduction trait |
male |
days
| 3 |
15.4 |
ms |
0.92 |
1.59 |
electrocardiography |
0.0 |
|
|
|
|
|
105586 |
3018 |
| F344 |
ST interval |
4-methyl-2-(piperidin-1-yl)-quinoline (1 mg/g) (for 0.5 hours) |
Westlund KN, et al., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3. |
heart electrical impulse conduction trait |
male |
days
| 3 |
57.59 |
ms |
1.1 |
1.91 |
electrocardiography |
0.0 |
|
|
|
|
|
105592 |
3018 |