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Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
growth factor complex +     
insulin-like growth factor binding protein complex +   
platelet-derived growth factor complex  
A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerization and activation. PDGFs are involved in a wide variety of signaling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD).
VEGF-A complex  

Synonyms
Narrow Synonyms: PDGF-AA dimer ;   PDGF-AB dimer ;   PDGF-BB dimer ;   PDGF-CC dimer ;   PDGF-DD dimer
Related Synonyms: PDGF complex
Definition Sources: GOC:bhm, PMID:11331882

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