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Pathways
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Ontology Browser
Term:
MyD88-dependent toll-like receptor 4 signaling pathway (GO:0035660)
Annotations: Rat: (1) Mouse: (1) Human: (1) Chinchilla: (1) Bonobo: (1) Dog: (1) Squirrel: (1) Pig: (1) Naked Mole-rat: (1) Green Monkey: (1)
Parent Terms Term With Siblings Child Terms
MyD88-dependent toll-like receptor 2 signaling pathway 
MyD88-dependent toll-like receptor 4 signaling pathway  
The series of molecular signals initiated by a ligand binding to a toll-like 4 receptor, where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 4 receptors bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
negative regulation of MyD88-dependent toll-like receptor signaling pathway  
negative regulation of toll-like receptor 4 signaling pathway  
positive regulation of MyD88-dependent toll-like receptor signaling pathway 
positive regulation of toll-like receptor 4 signaling pathway  
regulation of MyD88-dependent toll-like receptor signaling pathway +   
regulation of toll-like receptor 4 signaling pathway +   
TIRAP-dependent toll-like receptor 4 signaling pathway  
TRAM-dependent toll-like receptor 4 signaling pathway  
TRIF-dependent toll-like receptor 4 signaling pathway 

Synonyms
Exact Synonyms: MyD88-dependent TLR4 signaling pathway ;   MyD88-dependent toll-like receptor 4 signalling pathway
Definition Sources: GOC:BHF, PMID:18304834, PMID:20385024

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