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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
lncRNA-mediated post-transcriptional gene silencing  
lsiRNA processing 
miRNA-mediated post-transcriptional gene silencing +   
A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants.
negative regulation of post-transcriptional gene silencing by regulatory ncRNA +   
piRNA-mediated gene silencing by mRNA destabilization +   
positive regulation of post-transcriptional gene silencing by RNA +   
regulation of post-transcriptional gene silencing by regulatory ncRNA +   
RNAi-mediated antiviral immune response +  
siRNA-mediated post-transcriptional gene silencing +   
sRNA-mediated post-transcriptional gene silencing 
transitive RNA interference +  

Synonyms
Exact Synonyms: gene silencing by miRNA ;   gene silencing by microRNA ;   microRNA-mediated gene silencing
Broad Synonyms: miRNA-mediated gene silencing
Definition Sources: GOC:aruk, GOC:bc, GOC:rl, PMID:14744438, PMID:15066275, PMID:15066283, PMID:23209154, PMID:23985560, PMID:28379604

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