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Term:
tRNA (cytidine-5-)-methyltransferase activity (GO:0016428)
Annotations: Rat: (4) Mouse: (5) Human: (4) Chinchilla: (4) Bonobo: (4) Dog: (4) Squirrel: (4) Pig: (4) Naked Mole-rat: (4) Green Monkey: (4)
Parent Terms Term With Siblings Child Terms
tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase activity  
tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase activity 
tRNA (cytidine(34)-2'-O)-methyltransferase activity 
tRNA (cytidine(56)-2'-O)-methyltransferase activity 
tRNA (cytidine-3-)-methyltransferase activity  
tRNA (cytidine-5-)-methyltransferase activity  
Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H+. This modification can occur on seversal residues, including cytidine(34), cytidine(40), cytidine(48), and cytidine(49).

Synonyms
Exact Synonyms: tRNA (cytosine-5-)-methyltransferase activity
Related Synonyms: S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity ;   transfer RNA cytosine 5-methyltransferase activity ;   transfer ribonucleate cytosine 5-methyltransferase activity
Xrefs: RHEA:61468 ;   reactome:R-HSA-6782388 "NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA)" ;   reactome:R-HSA-6782419 "TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)" ;   reactome:R-HSA-6785409 "NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)" ;   reactome:R-HSA-6785438 "NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)" ;   reactome:R-HSA-8932765 "NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)"
Definition Sources: RHEA:61468

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