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Term:
Parent Terms Term With Siblings Child Terms
cysteine-type deNEDDylase activity 
cysteine-type deubiquitinase activity +   
An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
cysteine-type endopeptidase activity +   
cysteine-type exopeptidase activity +   
deSUMOylase activity  
deUFMylase activity  
gamma-glutamyl-peptidase activity  
histone deubiquitinase activity +   
ISG15-specific peptidase activity  
K11-linked deubiquitinase activity  
K48-linked deubiquitinase activity  
K63-linked deubiquitinase activity  
metal-dependent deubiquitinase activity  
pyroglutamyl-peptidase activity  

Synonyms
Exact Synonyms: deubiquitinase ;   deubiquitylase ;   thiol-dependent deubiquitinase ;   thiol-dependent ubiquitin-specific protease activity ;   thiol-dependent ubiquitinyl hydrolase activity ;   ubiquitin hydrolase activity
Narrow Synonyms: UBP ;   UCH2 ;   deubiquitinase activity ;   deubiquitinating enzyme ;   ubiquitinyl hydrolase 1 activity
Broad Synonyms: ubiquitin-specific protease activity ;   ubiquitinyl hydrolase activity
Related Synonyms: ubiquitin C-terminal hydrolase
Alternate IDs: GO:0036459
Xrefs: EC:3.4.19.12 ;   Reactome:R-HSA-3640872 "USP34 deubiquitinates AXIN1,AXIN2" ;   Reactome:R-HSA-5688797 "ATXN3 family cleave Ub chains" ;   Reactome:R-HSA-5688837 "ATXN3 deubiquitinates polyUb-PARK2" ;   Reactome:R-HSA-5689950 "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN" ;   Reactome:R-HSA-5689972 "USP2 deubiquitinates MDM2,MDM4" ;   Reactome:R-HSA-5689973 "USP10,USP24,USP42 deubiquitinate TP53" ;   Reactome:R-HSA-5690080 "USP3,SAGA deubiquitinate Histone H2A,H2B" ;   Reactome:R-HSA-5690152 "USP5 cleaves polyubiquitin" ;   Reactome:R-HSA-5690157 "USP16,USP21 deubiquitinate Histone H2A"
Definition Sources: GOC:jh2, PMID:30783221

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