The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Adenosine triphosphate (ATP) extracellular signaling activates the P2X ligand-gated ion channels that are permeable to sodium, potassium and calcium ions. There are several P2X subtypes that are involved in a range of physiological processes. ATP along with other nucleotide also engages a class of metabotropic purinergic receptors known as P2Y that couple to either the Galphaq or to G alphai subunit of heterotrimeric G proteins. ATP is the sole ligand of P2Y 11 receptor.