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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2
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Accession:PW:0000586 term browser browse the term
Definition:Orexin/hypocretin signaling through receptor 2 couples to Galphaq and the inhibitory Galphai classes of G proteins. Orexin/hypocretin receptor 2 binds both orexin A and B derived from the prepro-orexin precursor.


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orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAI1 G protein subunit alpha i1 ISO RGD PMID:12890892 RGD:1642020 NCBI chr 7:72,102,937...72,188,124
Ensembl chr 7:85,812,249...85,851,283 		JBrowse link
G HCRT hypocretin neuropeptide precursor ISO RGD PMID:12890892 RGD:1642020 NCBI chr17:15,130,581...15,132,024
Ensembl chr17:15,353,203...15,354,594 		JBrowse link
G HCRTR2 hypocretin receptor 2 ISO RGD PMID:12890892 RGD:1642020 NCBI chr 6:54,722,279...54,835,963
Ensembl chr 6:56,327,340...56,469,901 		JBrowse link
G LOC100986730 guanine nucleotide-binding protein G(q) subunit alpha ISO RGD PMID:12890892 RGD:1642020 NCBI chr 9:46,816,409...47,129,116
Ensembl chr 9:76,575,815...76,773,849 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4064
    signaling pathway 1930
      hormone signaling pathway 380
        peptide and protein hormone signaling pathway 273
          orexin/hypocretin signaling pathway 5
            orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2 4
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