Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased DN4 thymocyte number
go back to main search page
Accession:MP:0010135 term browser browse the term
Definition:increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive.
Comment:Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain.
Synonyms:exact_synonym: increased DN4 alpha-beta immature T-lymphocyte number;   increased DN4 cell number;   increased DN4 immature T cell number
 xref: CL:0000808


show annotations for term's descendants           Sort by:
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5428
    hematopoietic system phenotype 267
      abnormal hematopoietic system morphology/development 247
        abnormal thymus morphology 82
          increased thymocyte number 0
            increased DN4 thymocyte number 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5428
    hematopoietic system phenotype 267
      abnormal hematopoietic system morphology/development 247
        abnormal hematopoietic cell morphology 182
          abnormal blood cell morphology 95
            abnormal hemopoiesis 16
              abnormal definitive hematopoiesis 16
                abnormal leukopoiesis 16
                  abnormal lymphopoiesis 16
                    abnormal T cell differentiation 16
                      abnormal double-negative T cell morphology 2
                        increased double-negative T cell number 2
                          increased DN4 thymocyte number 0
paths to the root