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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal mammary duct terminal end bud morphology
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Accession:MP:0013782 term browser browse the term
Definition:any structural anomaly of the unique club-shaped epithelial structure that develops at the tip of the mammary duct at the onset of puberty (approximately 3 weeks of age in mouse) under the action of circulating hormones; terminal end buds (TEBs) consist of an outer layer of undifferentiated myoepithelial progenitor cells (cap cells), and a multilayered inner core of luminal epithelial cells (body) fated to form the walls of the ductal lumen; both layers have high rates of mitosis, consistent with a motile organ dedicated to ductal morphogenesis; TEBs proliferate, ramify, and actively invade the fad pad to allow the formation of a complex branching structure; this process of branching morphogenesis concludes at about 10-12 weeks of age in mouse, when TEBs have traversed the length of the fat pad and a fully developed ductal tree has formed
Synonyms:exact_synonym: abnormal mammary duct TEB morphology


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abnormal mammary duct terminal end bud morphology term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
S SPRD.WKY-(D18Wox8-D18Rat44)/Ibmm induced IAGP compared to WKY RGD PMID:17597107 RGD:1643011 NCBI chr18:19,278,901...83,218,561 JBrowse link
S SPRD.WKY-(D5Rat190-D5Rat114)/Ibmm induced IAGP compared to WKY RGD PMID:17597107 RGD:1643011
S SPRD/Ztm induced IAGP compared to WKY RGD PMID:17597107 RGD:1643011
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5420
    integument phenotype 171
      abnormal skin adnexa morphology 169
        abnormal mammary gland morphology 99
          abnormal mammary gland epithelium morphology 8
            abnormal mammary gland duct morphology 3
              abnormal mammary duct terminal end bud morphology 3
                decreased mammary duct terminal end bud number + 0
                increased mammary duct terminal end bud number 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5420
    endocrine/exocrine gland phenotype 394
      abnormal gland morphology 333
        abnormal exocrine gland morphology 119
          abnormal apocrine gland morphology 99
            abnormal mammary gland morphology 99
              abnormal mammary gland epithelium morphology 8
                abnormal mammary gland duct morphology 3
                  abnormal mammary duct terminal end bud morphology 3
                    decreased mammary duct terminal end bud number + 0
                    increased mammary duct terminal end bud number 0
paths to the root