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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Substantia nigra dopaminergic neuron loss
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Accession:HP:0034694 term browser browse the term
Definition:Degeneration and loss of neurons in the substantia nigra of the brain.
Comment:Ppigmented neurons in the substantia nigra produce the neurotransmitter dopamine. The loss of these neurons leads to the classical motor symptoms of Parkinson disease. The pigment contained within these neurons, termed neuromelanin because of its similar appearance to cutaneous melanin, is so abundant in the substantia nigra of the human brain that this structure can be seen macroscopically as a darkened area (hence the origin of the name given to this brain region)
Synonyms:related_synonym: Melanin reduced in substantia nigra


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Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the nervous system 0
        Abnormal nervous system morphology 0
          Morphological central nervous system abnormality 0
            Abnormal brain morphology 0
              Abnormal midbrain morphology 0
                Abnormal substantia nigra morphology 0
                  Substantia nigra dopaminergic neuron loss 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the nervous system 0
        Abnormal nervous system morphology 0
          Morphological central nervous system abnormality 0
            Abnormal brain morphology 0
              Abnormal forebrain morphology 0
                Abnormal cerebral morphology 0
                  Abnormal cerebral subcortex morphology 0
                    Abnormal basal ganglia morphology 0
                      Abnormal substantia nigra morphology 0
                        Substantia nigra dopaminergic neuron loss 0
paths to the root