Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


The Human Phenotype Ontology (HPO) is downloaded weekly from The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at

Term:Acral overgrowth
go back to main search page
Accession:HP:0033794 term browser browse the term
Definition:Excessive growth of hands and feet (predominantly due to soft tissue swelling). Typical manifestations include shoe size increase, foot enlargment, glove tightness, and hand enlargement.
Comment:This term should be used to encode the overgrowth of hands and feet that can be seen in acromegaly, a rare disorder caused by excessive growth hormone production, most commonly from an adenoma of the anterior pituitary gland. The resulting production of insulin-like growth factor 1 causes the characteristic overgrowth of certain tissues resulting in coarsening of facial features, enlarging hands and feet, as well as effects on multiple systems throughout the body. The Figure in PMID:30853479 illustrates large hands with stubby fingers characteristic of acromegaly.
Synonyms:exact_synonym: Acral enlargement;   Acral hypertrophy;   Acromegalic growth
 related_synonym: Acromegaly

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:

Term paths to the root
Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Growth abnormality 0
        Acral overgrowth 0
paths to the root