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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Decreased circulating IgG subclass level
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Accession:HP:0032135 term browser browse the term
Definition:A reduction below the normal concentration of a subclass of immunoglobulin G (IgG) in the blood.
Comment:IgG subclass deficiency is defined as a reduction in 1 or more subclasses of IgG (IgG1 and IgG2 in particular) by more than 2 SDs below the mean for age-matched controls. Deficiencies in IgG1 or IgG2 are more likely to cause low serum IgG levels because these are the major components. IgG1 levels stabilize by the age of 5 years; however, adult levels of IgG2, IgG3, and IgG4 may not be achieved until adolescence. Thus, the interpretation of subclass levels is additionally problematic because levels of each subclass increase at different rates during development.
Synonyms:exact_synonym: Decreased IgG subclass level in blood


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Term paths to the root
Path 1
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the immune system 0
        Abnormality of immune system physiology 0
          Abnormality of humoral immunity 0
            Abnormal immunoglobulin level 0
              Decreased circulating antibody level 0
                Decreased circulating IgG level 0
                  Decreased circulating IgG subclass level 0
                    Decreased circulating IgG1 level + 0
                    Decreased circulating IgG2 level + 0
                    Decreased circulating IgG3 level + 0
                    Decreased circulating IgG4 level + 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the immune system 0
        Abnormality of immune system physiology 0
          Abnormal leukocyte physiology 0
            Abnormal lymphocyte physiology 0
              Abnormality of B cell physiology 0
                Abnormal immunoglobulin level 0
                  Decreased circulating antibody level 0
                    Decreased circulating IgG level 0
                      Decreased circulating IgG subclass level 0
                        Decreased circulating IgG1 level + 0
                        Decreased circulating IgG2 level + 0
                        Decreased circulating IgG3 level + 0
                        Decreased circulating IgG4 level + 0
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