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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Elevated circulating alanine aminotransferase concentration
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Accession:HP:0031964 term browser browse the term
Definition:An abnormally high concentration in the circulation of alanine aminotransferase (ALT).
Comment:Alanine aminotransferase (ALT) is an enzyme that catalyzes the transfer of amino groups to form the hepatic metabolite oxaloacetate. ALT is found abundantly in the cytosol of the hepatocyte. ALT activity in the liver is about 3000 times that of serum activity. Thus, in the case of hepatocellular injury or death, release of ALT from damaged liver cells increases measured ALT activity in the serum. Although it is generally thought to be specific to the liver, it is also found in the kidney, and, in much smaller quantities, in heart and skeletal muscle cells.
Synonyms:exact_synonym: Alanine aminotransferase increased;   Elevated serum ALT;   Elevated serum alanine aminotransferase;   Elevated serum glutamic-pyruvic transaminase


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of metabolism/homeostasis 0
        Abnormal enzyme concentration or activity 0
          Abnormal circulating enzyme concentration or activity 0
            Abnormal circulating hepatic transaminase concentration 0
              Elevated circulating hepatic transaminase concentration 0
                Elevated circulating alanine aminotransferase concentration 0
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