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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Spermatogenesis maturation arrest
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Accession:HP:0031038 term browser browse the term
Definition:Maturation arrest (MA) is defined as germ cells that fail to complete maturation. Uniform MA is characterized by spermatogenic arrest at the same stage of spermatogenesis throughout the seminiferous tubules. MA is subcategorized into early MA, in which only spermatogonia or spermatocytes are found, and late MA, in which spermatids are detected without spermatozoa.
Comment:Maturation arrest (MA) of spermatogenesis is diagnosed on histology as interruption of spermatogenesis before the final stage without impairment of Sertoli or Leydig cells. It is considered a condition of irreversible or absolute infertility.
Synonyms:exact_synonym: Meiotic maturation arrest of spermatogenesis


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  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the genitourinary system 0
        Abnormality of the genital system 0
          Abnormality of reproductive system physiology 0
            Abnormal male reproductive system physiology 0
              Functional abnormality of male internal genitalia 0
                Abnormal spermatogenesis 0
                  Spermatogenesis maturation arrest 0
                    Round spermatid arrest 0
                    Spermatocyte maturation arrest 0
                    Spermatogonial maturation arrest 0
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