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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Schizophrenia
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Accession:HP:0100753 term browser browse the term
Definition:A mental disorder characterized by a disintegration of thought processes and emotional responsiveness. It most commonly manifests as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking. It is accompanied by significant social or occupational dysfunction. The onset of symptoms typically occurs in young adulthood, with a global lifetime prevalence of about 1%. This term is not a helpful parent term to describe abnormal experiences.
Comment:Positive symptoms, such as delusions and hallucinations (especially of voices), are common, and any Schneiderian first-rank symptoms are particularly indicative of the illness. Negative symptoms include social withdrawal, impairment of ego boundaries, and loss of energy and initiative. Schizophrenia is diagnosed only if symptoms persist for at least one month. The illness can spontaneously remit, run a course with infrequent or frequent relapses, or become chronic. The prognosis has improved with antipsychotic drugs and with vigorous psychological and social management and rehabilitation. The many causes include genetic factors, environmental stress, and various triggering factors.
Synonyms:narrow_synonym: Schizoaffective disorder-bipolar type;   treatment refractory schizophrenia
 xref: EFO:0004609;   EFO:0009965;   MESH:D012559;   SNOMEDCT_US:191526005;   SNOMEDCT_US:58214004;   UMLS:C0036341


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      Human phenotype 21570
        Phenotypic abnormality 21560
          Abnormality of the nervous system 15611
            Abnormal nervous system physiology 14502
              Abnormality of mental function 13133
                Abnormal experience of reality 4680
                  Abnormal psychotic pattern 4309
                    Schizophrenia 4180
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