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HUMAN PHENOTYPE - ANNOTATIONS

The Human Phenotype Ontology (HPO) is downloaded weekly from http://compbio.charite.de/hudson/job/hpo/lastStableBuild/artifact/ontology/release/hp.obo. The file downloaded is considered the "last stable build" available for the ontology. For more about the HPO, view their website at http://www.human-phenotype-ontology.org/.
Term:Elevated circulating reverse T3 concentration
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Accession:HP:0034288 term browser browse the term
Definition:Abnormally increased concentration of reverse T3 (3,3',5'-triiodothyronine or rT3) in the blood circulation.
Comment:Reverse T3 is the third most abundant iodothyronine circulating in human blood and is produced by the inner ring deiodination of the pro-hormone thyroxine (T4). The number 4 in T4 means it has 4 iodine atoms. It can lose 1 of them, yielding either T3 or reverse T3, depending on which iodine atom it loses. Loss of iodine from the five-prime position on its outer ring yields T3, the most potent thyroid hormone. On the other hand, when T4 loses an iodine atom from the five position on its inner ring it yields reverse T3. Reverse T3 is inactive.
Synonyms:exact_synonym: Elevated circulating reverse triiodothyronine concentration;   Elevated rT3


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Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the endocrine system 0
        Abnormal circulating hormone concentration 0
          Abnormal circulating thyroid hormone concentration 0
            Elevated circulating reverse T3 concentration 0
Path 2
Term Annotations click to browse term
  Human phenotype 0
    Phenotypic abnormality 0
      Abnormality of the endocrine system 0
        Abnormality of the thyroid gland 0
          Abnormality of thyroid physiology 0
            Abnormal circulating thyroid hormone concentration 0
              Elevated circulating reverse T3 concentration 0
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