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ONTOLOGY REPORT - ANNOTATIONS


Term:S100A9 complex
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Accession:GO:1990662 term browser browse the term
Definition:A protein complex composed of a S100A9 dimer and capable of binding to toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Transports arachidonic acid between the cytosol and the NADPH oxidase complex at the plasma membrane in neutrophils as part of an inflammatory signal cascade leading to an oxidative burst. Complexes with microtubules to increase cell motility.
Comment:An example of this is S100A9 in human (UniProt symbol P06702) in PMID:15642721 (inferred from direct assay).
Synonyms:exact_synonym: S100A9 homodimer



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S100A9 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G S100a9 S100 calcium binding protein A9 part_of IEA
ISO
GO_REF:0000107
(PMID:11851337)
Ensembl
RGD
PMID:11851337 GO_REF:0000107 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
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Path 1
Term Annotations click to browse term
  cellular_component 21321
    protein-containing complex 6790
      membrane protein complex 1432
        transmembrane transporter complex 536
          S100A9 complex 1
Path 2
Term Annotations click to browse term
  cellular_component 21321
    cellular anatomical structure 21026
      membrane 10474
        membrane protein complex 1432
          transmembrane transporter complex 536
            S100A9 complex 1
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