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ONTOLOGY REPORT - ANNOTATIONS

Term:Ire1 complex
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Accession:GO:1990332 term browser browse the term
Definition:A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript.
Comment:An example of this is Ire1 in S. cerevisiae (P32361) in PMID:18191223 (inferred from direct assay).
Synonyms:exact_synonym: ER-bound kinase/endoribonuclease (RNase), inositol-requiring enzyme-1;   IRE1 dimer;   Ire1 complex dimer;   Ire1 complex homodimer;   Ire1 complex homooligomer
 related_synonym: ERN1 complex


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  cellular_component 20833
    protein-containing complex 6558
      membrane protein complex 1410
        Ire1 complex 0
Path 2
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  cellular_component 20833
    cellular anatomical structure 20633
      organelle 13975
        intracellular organelle 13569
          intracellular membrane-bounded organelle 12009
            endoplasmic reticulum 1877
              endoplasmic reticulum subcompartment 1110
                endoplasmic reticulum membrane 1100
                  Ire1 complex 0
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