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ONTOLOGY REPORT - ANNOTATIONS

Term:tRNA (adenine(58)-N1)-methyltransferase activity
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Accession:GO:0160107 term browser browse the term
Definition:Catalysis of the reaction: adenosine(58) in tRNA + S-adenosyl-L-methionine = H+ + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine.
Synonyms:exact_synonym: tRNA (adenine(58)-N(1))-methyltransferase activity;   tRNA m(1)A(58) methyltransferase
 xref: EC:2.1.1.220;   RHEA:43152;   Reactome:R-HSA-6783492 "TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)";   Reactome:R-HSA-6787525 "TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58"


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tRNA (adenine(58)-N1)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trmt61a tRNA methyltransferase 61A enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 6:136,558,417...136,564,411
Ensembl chr 6:130,737,219...130,743,243 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21088
    catalytic activity 6122
      catalytic activity, acting on a nucleic acid 630
        catalytic activity, acting on RNA 389
          RNA methyltransferase activity 63
            tRNA methyltransferase activity 31
              tRNA (adenine) methyltransferase activity 3
                tRNA (adenine(58)-N1)-methyltransferase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 21088
    catalytic activity 6122
      transferase activity 2441
        transferase activity, transferring one-carbon groups 214
          methyltransferase activity 203
            RNA methyltransferase activity 63
              tRNA methyltransferase activity 31
                tRNA (adenine) methyltransferase activity 3
                  tRNA (adenine(58)-N1)-methyltransferase activity 1
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