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ONTOLOGY REPORT - ANNOTATIONS

Term:histone H3K27 trimethyltransferase activity
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Accession:GO:0140951 term browser browse the term
Definition:Catalysis of the reaction: L-lysyl27-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me3.
Synonyms:exact_synonym: histone H3-K27 trimethylase activity;   histone H3K27 mono/di/trimethylase activity;   histone H3K27 trimethylase activity;   histone lysine N-trimethyltransferase activity (H3-K27 specific)
 broad_synonym: histone H3-K27 trimethylation;   histone H3K27 trimethylation
 xref: EC:2.1.1.356;   RHEA:60292

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histone H3K27 trimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsd3 nuclear receptor binding SET domain protein 3 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624780:5,241,556...5,367,815
Ensembl chrNW_004624780:5,241,537...5,363,325 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 16258
    catalytic activity 5070
      catalytic activity, acting on a protein 2057
        protein methyltransferase activity 94
          protein-lysine N-methyltransferase activity 55
            histone H3K27 methyltransferase activity 6
              histone H3K27 trimethyltransferase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 16258
    catalytic activity 5070
      transferase activity 2174
        transferase activity, transferring one-carbon groups 217
          methyltransferase activity 209
            S-adenosylmethionine-dependent methyltransferase activity 152
              lysine N-methyltransferase activity 55
                protein-lysine N-methyltransferase activity 55
                  histone H3K27 methyltransferase activity 6
                    histone H3K27 trimethyltransferase activity 1
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