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ONTOLOGY REPORT - ANNOTATIONS

Term:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity
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Accession:GO:0102158 term browser browse the term
Definition:Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA = H2O + a very-long-chain (2E)-enoyl-CoA. This reaction is the third (dehydration) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit.
Synonyms:exact_synonym: very-long-chain 3-hydroxyacyl-CoA dehydratase activity
 xref: EC:4.2.1.134;   MetaCyc:RXN-11750;   RHEA:45812


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very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hacd1 3-hydroxyacyl-CoA dehydratase 1 enables IEA
ISO		 GO_REF:0000003
GO_REF:0000116
(PMID:18554506)		 UniProt
RHEA
RGD		 PMID:18554506 GO_REF:0000003 GO_REF:0000116 NCBI chr17:77,081,508...77,106,114
Ensembl chr17:77,083,740...77,106,073 		JBrowse link
G Hacd2 3-hydroxyacyl-CoA dehydratase 2 enables ISO (PMID:18554506) RGD PMID:18554506 NCBI chr11:65,667,671...65,762,903
Ensembl chr11:65,670,281...65,762,889 		JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 enables ISO (PMID:18554506) RGD PMID:18554506 NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507 		JBrowse link
G Hacd4 3-hydroxyacyl-CoA dehydratase 4 enables ISO (PMID:18554506) RGD PMID:18554506 NCBI chr 5:102,887,597...102,915,376
Ensembl chr 5:102,887,588...102,915,338 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 21091
    catalytic activity 6174
      lyase activity 214
        carbon-oxygen lyase activity 89
          hydro-lyase activity 69
            enoyl-CoA hydratase activity 10
              3-hydroxyacyl-CoA dehydratase activity 7
                very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity 4
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