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ONTOLOGY REPORT - ANNOTATIONS

Term:N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
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Accession:GO:0050509 term browser browse the term
Definition:Catalysis of the reaction: 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H+ + UDP.
Synonyms:exact_synonym: N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity
 related_synonym: N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase activity;   UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase activity;   heparan glucuronyltransferase II activity
 xref: EC:2.4.1.225;   MetaCyc:2.4.1.225-RXN;   RHEA:20908;   Reactome:R-HSA-3656257 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan";   Reactome:R-HSA-3656267 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan";   Reactome:R-HSA-9036285 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan";   Reactome:R-HSA-9036289 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan";   reactome:R-HSA-2022856 "EXT1:EXT2 transfers GlcNAc to heparan";   reactome:R-HSA-2076392 "EXT1:EXT2 transfers GlcA to heparan"

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N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ext1 exostosin glycosyltransferase 1 enables IEA UniProt GO_REF:0000003 NCBI chrNW_004624763:16,126,582...16,393,476
Ensembl chrNW_004624763:16,126,938...16,392,804 		JBrowse link
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  molecular_function 17910
    catalytic activity 5586
      transferase activity 2398
        glycosyltransferase activity 289
          hexosyltransferase activity 196
            glucuronosyltransferase activity 22
              N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity 1
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