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ONTOLOGY REPORT - ANNOTATIONS

Term:3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity
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Accession:GO:0047751 term browser browse the term
Definition:Catalysis of the reaction: 3-oxo-5alpha-steroid + NADP+ = a 3-oxo-delta(4)-steroid + H+ + NADPH.
Synonyms:narrow_synonym: cholestenone 5a-reductase activity;   progesterone 5-alpha-reductase activity;   testosterone 5alpha-reductase
 broad_synonym: 3-oxosteroid delta4-dehydrogenase;   steroid 5alpha-reductase;   sterol 5-alpha reductase activity
 related_synonym: 3-oxosteroid 5alpha-reductase activity;   cholestenone 5-alpha-reductase activity;   cholestenone 5alpha-reductase activity;   steroid 5alpha-hydrogenase activity;   testosterone delta4-hydrogenase activity
 xref: EC:1.3.1.22;   KEGG_REACTION:R02610;   MetaCyc:1.3.99.5-RXN;   RHEA:54384


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3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SRD5A2 steroid 5 alpha-reductase 2 enables IEA Ensembl GO_REF:0000107 NCBI chr17:25,017,113...25,056,156
Ensembl chr17:25,017,113...25,056,544 		JBrowse link
G SRD5A3 steroid 5 alpha-reductase 3 enables IEA UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107 NCBI chr13:47,627,854...47,643,116
Ensembl chr13:47,627,913...47,642,566 		JBrowse link
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  molecular_function 21949
    catalytic activity 5722
      oxidoreductase activity 775
        steroid dehydrogenase activity 30
          steroid dehydrogenase activity, acting on the CH-CH group of donors 4
            3-oxo-5-alpha-steroid 4-dehydrogenase activity 3
              3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity 2
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