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ONTOLOGY REPORT - ANNOTATIONS

Term:3-oxo-5-alpha-steroid 4-dehydrogenase activity
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Accession:GO:0003865 term browser browse the term
Definition:Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor.
Synonyms:broad_synonym: 3-oxosteroid delta4-dehydrogenase;   5alpha-reductase;   delta4-3-oxosteroid-5alpha-reductase;   steroid 5 alpha reductase;   steroid 5-alpha-reductase activity;   steroid 5alpha-reductase;   testosterone 5alpha-reductase
 related_synonym: 3-keto-delta4-steroid-5alpha-reductase activity;   3-oxo-5alpha-steroid 4-dehydrogenase activity;   3-oxo-5alpha-steroid delta4-dehydrogenase activity;   3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity;   4-ene-3-ketosteroid-5alpha-oxidoreductase activity;   delta4-3-ketosteroid5alpha-oxidoreductase activity;   delta4-3-oxo steroid reductase activity;   delta4-5alpha-dehydrogenase activity;   steroid delta4-5alpha-reductase activity
 xref: EC:1.3.99.5;   MetaCyc:1.3.99.5-RXN;   RHEA:13805;   Reactome:R-HSA-469659 "SRD5A1 dehydrogenates TEST to DHTEST";   Reactome:R-HSA-9705713 "SRD5A2 dehydrogenates TEST to DHTEST";   Reactome:R-HSA-9705714 "SRD5A3 dehydrogenates TEST to DHTEST"


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3-oxo-5-alpha-steroid 4-dehydrogenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srd5a1 steroid 5 alpha-reductase 1 enables TAS
IBA
ISO
IDA
ISS		 GO_REF:0000033
(PMID:15249131)
(PMID:17986282)
GO_REF:0000024		 GO_Central
RGD
UniProt		 PMID:15249131 PMID:17986282 PMID:2476440 PMID:7482629 GO_REF:0000024 GO_REF:0000033, RGD:730219, RGD:2326071 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 enables IDA
IBA
ISO		 GO_REF:0000033
MGI:2178039 (PMID:11606430), (PMID:15249131)		 GO_Central
RGD		 PMID:11606430 PMID:15249131 PMID:1527072 PMID:7662592 GO_REF:0000033, RGD:729939, RGD:2326072 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
G Srd5a3 steroid 5 alpha-reductase 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:32,046,408...32,060,796
Ensembl chr14:32,046,408...32,060,747 		JBrowse link
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srd5a1 steroid 5 alpha-reductase 1 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 enables ISO (PMID:1944596) RGD PMID:1944596 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
G Srd5a3 steroid 5 alpha-reductase 3 enables IEA
ISS
ISO		 GO_REF:0000003
GO_REF:0000024
(PMID:17986282)		 UniProt
RGD		 PMID:17986282 GO_REF:0000003 GO_REF:0000024 NCBI chr14:32,046,408...32,060,796
Ensembl chr14:32,046,408...32,060,747 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      oxidoreductase activity 871
        oxidoreductase activity, acting on the CH-CH group of donors 68
          steroid dehydrogenase activity, acting on the CH-CH group of donors 4
            3-oxo-5-alpha-steroid 4-dehydrogenase activity 3
              3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity 3
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