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ONTOLOGY REPORT - ANNOTATIONS

Term:porphobilinogen synthase activity
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Accession:GO:0004655 term browser browse the term
Definition:Catalysis of the reaction: 2 5-aminolevulinate = 2 H2O + H+ + porphobilinogen.
Synonyms:exact_synonym: aminolevulinate dehydratase activity;   delta-aminolevulinic acid dehydratase activity
 related_synonym: 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing);   5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming);   5-levulinic acid dehydratase activity;   aminolevulinic dehydratase activity;   delta-aminolevulinate dehydratase activity;   delta-aminolevulinic acid dehydrase activity;   delta-aminolevulinic dehydratase activity
 xref: EC:4.2.1.24;   KEGG_REACTION:R00036;   MetaCyc:PORPHOBILSYNTH-RXN;   RHEA:24064;   reactome:R-HSA-189439 "ALAD condenses 2 dALAs to form PBG"


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porphobilinogen synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase enables IDA
ISO
ISS
IEA
IBA		 (PMID:11032836), (PMID:8175643)
GO_REF:0000024
GO_REF:0000002
GO_REF:0000033
(PMID:14050799), (PMID:4959158), (PMID:4981581), (PMID:5393940)		 RGD
UniProt
InterPro
GO_Central		 PMID:4959158 PMID:4981581 PMID:5393940 PMID:8175643 PMID:11032836 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033, RGD:4144201 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
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  molecular_function 21086
    catalytic activity 6127
      lyase activity 214
        carbon-oxygen lyase activity 89
          hydro-lyase activity 69
            porphobilinogen synthase activity 1
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