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ONTOLOGY REPORT - ANNOTATIONS

Term:calcidiol 1-monooxygenase activity
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Accession:GO:0004498 term browser browse the term
Definition:Catalysis of the reaction: calcidiol + H+ + NADPH + O2 = calcitriol + H2O + NADP+.
Synonyms:exact_synonym: 25-hydroxy vitamin D3 1-alpha-hydroxylase activity;   calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
 narrow_synonym: cytochrome P450 CYP27B
 related_synonym: 1-hydroxylase-25-hydroxyvitamin D3 activity;   25-OHD-1 alpha-hydroxylase activity;   25-hydroxy D3-1alpha-hydroxylase activity;   25-hydroxycholecalciferol 1-monooxygenase activity;   25-hydroxycholecalciferol 1alpha-hydroxylase activity;   25-hydroxycholecalciferol-1-hydroxylase activity;   25-hydroxyvitamin D-1 alpha hydroxylase activity;   25-hydroxyvitamin D3 1alpha-hydroxylase activity
 xref: EC:1.14.15.18;   KEGG_REACTION:R03610;   MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN;   RHEA:20573;   Reactome:R-HSA-5602186 "Defective CYP27B1 does not hydroxylate CDL";   reactome:R-HSA-209868 "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D"


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calcidiol 1-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 enables TAS
IDA
ISO
IEA		 (PMID:15795327), (PMID:16549446), (PMID:17023519), (PMID:22862690), (PMID:9415400)
PMID:9333115
(MGI:1097206|PMID:9295274), (MGI:3590419|PMID:15972816)
GO_REF:0000107		 RGD
Ensembl		 PMID:9295274 PMID:9415400 PMID:15795327 PMID:15972816 PMID:16549446 More... GO_REF:0000107 MGI:1097206 MGI:3590419, RGD:68680, RGD:69372, RGD:69373 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
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