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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA-(apurinic or apyrimidinic site) endonuclease activity
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Accession:GO:0003906 term browser browse the term
Definition:Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).
Comment:Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.
Synonyms:exact_synonym: AP deoxyendoribonuclease activity;   abasic deoxyendoribonuclease activity;   apurinic deoxyendoribonuclease activity;   apurinic/apyrimidinic endodeoxyribonuclease activity;   apyrimidinic deoxyendoribonuclease activity;   deoxyribonuclease (apurinic or apyrimidinic) activity
 broad_synonym: UV endonuclease
 related_synonym: endonuclease VIII activity
 xref: reactome:R-HSA-110375 "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break";   reactome:R-HSA-5649711 "NEIL1,NEIL2 incises DNA strand 5' to the AP site";   reactome:R-HSA-5649725 "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)"

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DNA-(apurinic or apyrimidinic site) endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr29:20,978,878...20,981,393 JBrowse link
G APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2 enables IEA TreeGrafter GO_REF:0000118 NCBI chr  X:51,077,496...51,084,787
Ensembl chr  X:51,077,025...51,084,783 		JBrowse link
G APLF aprataxin and PNKP like factor enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr14:38,539,398...38,636,666
Ensembl chr14:38,540,084...38,636,569 		JBrowse link
G HMCES 5-hydroxymethylcytosine binding, ES cell specific NOT|enables ISO (PMID:30554877) UniProt PMID:30554877 NCBI chr22:51,759,776...51,785,902
Ensembl chr22:51,759,715...51,785,987 		JBrowse link
G HMGA1 high mobility group AT-hook 1 enables ISO (PMID:19465398) UniProt PMID:19465398 NCBI chr17:37,848,110...37,857,835
Ensembl chr17:37,849,412...37,853,880 		JBrowse link
G HMGA2 high mobility group AT-hook 2 enables ISO (PMID:19465398) UniProt PMID:19465398 NCBI chr11:61,509,114...61,655,633 JBrowse link
G NEIL1 nei like DNA glycosylase 1 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr26:8,074,706...8,082,437
Ensembl chr26:8,074,310...8,082,123 		JBrowse link
G NEIL2 nei like DNA glycosylase 2 enables IEA InterPro GO_REF:0000002 NCBI chr 8:7,319,721...7,338,683
Ensembl chr 8:7,319,585...7,338,602 		JBrowse link
G NEIL3 nei like DNA glycosylase 3 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:123,408,582...123,462,475
Ensembl chr 7:123,409,363...123,462,411 		JBrowse link
G NTHL1 nth like DNA glycosylase 1 enables IEA Ensembl
TreeGrafter
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr 5:1,936,415...1,946,468
Ensembl chr 5:1,936,524...1,946,434 		JBrowse link
G RPS3 ribosomal protein S3 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:66,629,895...66,636,462
Ensembl chr 1:66,629,954...66,635,344 		JBrowse link
class I DNA-(apurinic or apyrimidinic site) endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALKBH1 alkB homolog 1, histone H2A dioxygenase enables ISO (PMID:19959401) UniProt PMID:19959401 NCBI chr24:54,932,455...54,967,394 JBrowse link
G NEIL1 nei like DNA glycosylase 1 enables IEA UniProt GO_REF:0000003 NCBI chr26:8,074,706...8,082,437
Ensembl chr26:8,074,310...8,082,123 		JBrowse link
G NEIL2 nei like DNA glycosylase 2 enables IEA UniProt GO_REF:0000003 NCBI chr 8:7,319,721...7,338,683
Ensembl chr 8:7,319,585...7,338,602 		JBrowse link
G NEIL3 nei like DNA glycosylase 3 enables IEA UniProt GO_REF:0000003 NCBI chr 7:123,408,582...123,462,475
Ensembl chr 7:123,409,363...123,462,411 		JBrowse link
G NTHL1 nth like DNA glycosylase 1 enables IEA UniProt
RHEA
Ensembl		 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chr 5:1,936,415...1,946,468
Ensembl chr 5:1,936,524...1,946,434 		JBrowse link
G OGG1 8-oxoguanine DNA glycosylase enables IEA UniProt GO_REF:0000003 Ensembl chr22:45,758,626...45,763,779 JBrowse link
G POLB DNA polymerase beta enables IEA RHEA
Ensembl		 GO_REF:0000107 GO_REF:0000116 NCBI chr 8:40,332,165...40,368,065
Ensembl chr 8:40,332,208...40,372,582 		JBrowse link
G RPS3 ribosomal protein S3 enables IEA UniProt GO_REF:0000003 NCBI chr 1:66,629,895...66,636,462
Ensembl chr 1:66,629,954...66,635,344 		JBrowse link
class II DNA-(apurinic or apyrimidinic site) endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISO (PMID:11160897), (PMID:11286553), (PMID:1627644), (PMID:9804798) UniProt PMID:1627644 PMID:9804798 PMID:11160897 PMID:11286553 NCBI chr29:20,978,878...20,981,393 JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 18124
    catalytic activity 5457
      catalytic activity, acting on a nucleic acid 599
        catalytic activity, acting on DNA 253
          DNA-(apurinic or apyrimidinic site) endonuclease activity 14
            class I DNA-(apurinic or apyrimidinic site) endonuclease activity 8
            class II DNA-(apurinic or apyrimidinic site) endonuclease activity 1
paths to the root