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ONTOLOGY REPORT - ANNOTATIONS

Term:mRNA m(6)A methyltransferase activity
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Accession:GO:0001734 term browser browse the term
Definition:Catalysis of the reaction: an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + H+ + S-adenosyl-L-homocysteine. This activity is the methylation of adenines in mRNA with the consensus sequence RRACH, where R is a purine, and H is C, A, or U.
Synonyms:exact_synonym: mRNA (N6-adenosine)-methyltransferase activity
 xref: EC:2.1.1.348;   MetaCyc:RXN-19346;   RHEA:55584;   reactome:R-HSA-72095 "Internal Methylation of mRNA"
 only_in_taxon: NCBITaxon:2759 ! Eukaryota


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mRNA m(6)A methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G METTL14 methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit enables
NOT|enables		 IEA
ISO		 (PMID:27627798) Ensembl
UniProt		 PMID:27627798 GO_REF:0000107 NCBI chr32:37,653,163...37,679,577
Ensembl chr32:37,653,035...37,678,398 		JBrowse link
G METTL16 methyltransferase 16, RNA N6-adenosine enables IEA Ensembl GO_REF:0000107 NCBI chr 9:46,491,503...46,566,752
Ensembl chr 9:46,496,963...46,558,313 		JBrowse link
G METTL3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit enables IEA
IBA		 Ensembl
UniProt
GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr15:18,528,755...18,546,303
Ensembl chr15:18,528,772...18,546,531 		JBrowse link
G TMT1A thiol methyltransferase 1A enables IEA Ensembl GO_REF:0000107 NCBI chr27:3,858,792...3,866,350
Ensembl chr27:3,857,454...3,866,448 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21949
    catalytic activity 5722
      catalytic activity, acting on a nucleic acid 614
        catalytic activity, acting on RNA 381
          RNA methyltransferase activity 65
            mRNA methyltransferase activity 15
              mRNA m(6)A methyltransferase activity 4
Path 2
Term Annotations click to browse term
  molecular_function 21949
    catalytic activity 5722
      transferase activity 2314
        transferase activity, transferring one-carbon groups 216
          methyltransferase activity 201
            RNA methyltransferase activity 65
              mRNA methyltransferase activity 15
                mRNA m(6)A methyltransferase activity 4
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