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EXPERIMENTAL FACTOR ONTOLOGY - ANNOTATIONS

Term:paraneoplastic syndrome
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Accession:EFO:MONDO:0021073 term browser browse the term
Definition:A classification for rare disorders of diverse organ systems (endocrine, neuromuscular, gastrointestinal, renal, dermatologic, rheumatologic, hematologic) that are affected by substances secreted by a distant neoplasm but not by the action of the neoplasm itself metastasizing to that organ or tissue. Less than 1 % of neoplasms are associated with these syndromes. An immune-mediated response to neoplasm-elaborated proteins may be the cause of these syndromes. Additionally, their manifestation may signal the presence of an occult neoplasm, potentially at an earlier stage of disease thereby leading to a better clinical outcome. Constitutional signs may include fever, night sweats, anorexia and cachexia. Clinical course is usually progressive. Prognosis is variable depending on the effective treatment of the underlying neoplasm.
Synonyms:alt_id: MONDO:0021073
 xref: MESH:D010257;   NCI:C3311;   SCTID:49783001;   UMLS:C0030472

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Term Annotations click to browse term
  experimental factor 0
    material property 0
      disposition 0
        disease 0
          syndromic disease 0
            paraneoplastic syndrome 0
              paraneoplastic cutaneous syndrome + 0
              paraneoplastic gastrointestinal syndrome 0
              paraneoplastic hematological syndrome + 0
              paraneoplastic neurologic syndrome + 0
              paraneoplastic renal syndrome 0
              parneoplastic endocrine syndrome + 0
Path 2
Term Annotations click to browse term
  experimental factor 0
    material property 0
      disposition 0
        disease 0
          cancer or benign tumor 0
            cancer-related condition 0
              paraneoplastic syndrome 0
                paraneoplastic cutaneous syndrome + 0
                paraneoplastic gastrointestinal syndrome 0
                paraneoplastic hematological syndrome + 0
                paraneoplastic neurologic syndrome + 0
                paraneoplastic renal syndrome 0
                parneoplastic endocrine syndrome + 0
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