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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dasatinib (anhydrous)
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Accession:CHEBI:49375 term browser browse the term
Definition:An aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN).
Synonyms:related_synonym: BMS Dasatinib;   BMS-354825;   Formula=C22H26ClN7O2S;   InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27);   InChIKey=ZBNZXTGUTAYRHI-UHFFFAOYSA-N;   N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE;   SMILES=Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1;   anh. dasatinib;   dasatinib;   dasatinibum
 alt_id: CHEBI:38943;   CHEBI:49372
 xref: CAS:302962-49-8;   DrugBank:DB01254;   Drug_Central:785;   HMDB:HMDB0015384;   KEGG:D03658;   LINCS:LSM-1020
 xref_mesh: MESH:C488369
 xref: PDBeChem:1N1;   PMID:16775234;   PMID:17154512;   PMID:18020922;   PMID:18784745;   PMID:18797457;   PMID:18823558;   PMID:19494352;   PMID:19502192;   PMID:19640584;   PMID:21226671;   PMID:22411867;   PMID:22740998;   PMID:22992064;   PMID:23065516;   Patent:US7125875;   Patent:US7941725;   Patent:WO2010067374;   Patent:WO2010139979;   Reaxys:9966762;   Wikipedia:Dasatinib
 cyclic_relationship: is_conjugate_base_of CHEBI:190514



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Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19814
      biological role 19812
        antimicrobial agent 18164
          antiviral agent 11074
            anticoronaviral agent 9664
              dasatinib (anhydrous) 0
                dasatinib monohydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      carbon group element atom 19734
                        carbon atom 19731
                          organic molecular entity 19731
                            heteroorganic entity 19488
                              organochalcogen compound 19251
                                organooxygen compound 19168
                                  carbon oxoacid 18637
                                    carboxylic acid 18634
                                      carboacyl group 17696
                                        univalent carboacyl group 17696
                                          carbamoyl group 17546
                                            carboxamide 17546
                                              monocarboxylic acid amide 15681
                                                dasatinib (anhydrous) 0
                                                  dasatinib monohydrate 0
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