Term: | doxercalciferol |
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Accession: | CHEBI:4712
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Definition: | A hydroxy seco-steroid and synthetic vitamin D2 analogue that undergoes metabolic activation in vivo to form 1alpha,25-dihydroxyvitamin D2 (1alpha,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. It is used to treat secondary hyperparathyroidism, a condition in which the body produces excess parathyroid hormone (PTH; a natural substance needed to control the amount of calcium in the blood) in certain people with chronic kidney disease. |
Synonyms: | exact_synonym: | (1S,3R,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraene-1,3-diol |
| related_synonym: | 1alpha-Hydroxyergocalciferol; 1alpha-hydroxyvitamin D2; Formula=C28H44O2; InChI=1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1; InChIKey=HKXBNHCUPKIYDM-CGMHZMFXSA-N; SMILES=C1[C@]2([C@](/C(=C/C=C/3\\C([C@H](C[C@@H](C3)O)O)=C)/CC1)(CC[C@@]2([C@H](C)/C=C/[C@@H](C(C)C)C)[H])[H])C; doxercalciferolum; hectorol |
| xref: | CAS:54573-75-0; DrugBank:DB06410; Drug_Central:957; KEGG:C08211; KEGG:D01009; PDBeChem:V2H; PMID:12227689; PMID:12834181; PMID:17603751; PMID:21155068; PMID:21849802; PMID:22123370; PMID:23780943; PMID:25774916; PMID:28586017; Wikipedia:Doxercalciferol |
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