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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:provitamin
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Accession:CHEBI:50188 term browser browse the term
Definition:A substance that can be converted into a vitamin by animal tissues.
Synonyms:related_synonym: provitamins
 xref: Wikipedia:Provitamin


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alpha-carotene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mgmt O-6-methylguanine-DNA methyltransferase affects response to substance ISO MGMT gene SNP affects the susceptibility to alpha-carotene CTD PMID:16014702 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
astaxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA] CTD PMID:16964424 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA] CTD PMID:16964424 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G C1qa complement C1q A chain decreases expression ISO astaxanthine results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G Cat catalase multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA] CTD PMID:16964424 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cntd1 cyclin N-terminal domain containing 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA] CTD PMID:16964424 NCBI chr10:89,199,988...89,210,369
Ensembl chr10:89,199,880...89,209,393
JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA] CTD PMID:16964424 NCBI chr 1:263,494,850...263,511,510
Ensembl chr 1:263,494,852...263,511,505
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA] CTD PMID:16964424 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765
JBrowse link
G Cox5b cytochrome c oxidase subunit 5B multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA] CTD PMID:16964424 NCBI chr 9:43,259,706...43,262,039
Ensembl chr 9:43,259,709...43,262,040
JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA] CTD PMID:16964424 NCBI chr 1:89,075,987...89,084,834
Ensembl chr 1:89,075,975...89,084,859
Ensembl chr 2:89,075,975...89,084,859
JBrowse link
G Cox6c cytochrome c oxidase subunit 6C multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA] CTD PMID:16964424 NCBI chr 7:74,723,177...74,735,650
Ensembl chr 7:74,723,179...74,735,650
JBrowse link
G Ctss cathepsin S decreases expression ISO astaxanthine results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression
EXP astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 mRNA]]
astaxanthine results in decreased expression of NOX2 mRNA
CTD PMID:23272707 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
EXP astaxanthine results in increased expression of and results in increased activity of CYP1A1 protein
astaxanthine results in increased expression of CYP1A1 mRNA
CTD PMID:21414371 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA] CTD PMID:16964424 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
multiple interactions
EXP astaxanthine results in increased activity of G6PD protein
[Cadmium co-treated with astaxanthine] results in decreased activity of G6PD protein
CTD PMID:28665548, PMID:29975440 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO astaxanthine results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression
multiple interactions
ISO astaxanthine results in increased expression of GJA1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [astaxanthine results in increased expression of GJA1 protein]; astaxanthine promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]
CTD PMID:16091010 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gna13 G protein subunit alpha 13 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA] CTD PMID:16964424 NCBI chr10:97,647,196...97,680,030
Ensembl chr10:97,647,111...97,684,730
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA] CTD PMID:16964424 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP [mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRIN1 protein]] CTD PMID:23538867 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grn granulin precursor multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA] CTD PMID:16964424 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP astaxanthine inhibits the reaction [Cadmium results in decreased activity of GSR protein] CTD PMID:29975440 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions
increases expression
ISO [astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of GSTM2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of GSTM2 mRNA
astaxanthine results in increased expression of GSTM2 mRNA
CTD PMID:24157545 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA] CTD PMID:16964424 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
decreases expression
multiple interactions
EXP
ISO
astaxanthine results in increased expression of HMOX1 protein
astaxanthine results in decreased expression of HMOX1 mRNA
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of HMOX1 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]
astaxanthine results in increased expression of HMOX1 mRNA
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of HMOX1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of HMOX1 mRNA
CTD PMID:20038455, PMID:23272707, PMID:24157545 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hoxa9 homeobox A9 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA] CTD PMID:16964424
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA] CTD PMID:16964424 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO astaxanthine results in decreased expression of IL1B mRNA; astaxanthine results in decreased expression of IL1B protein CTD PMID:21621527 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression ISO astaxanthine results in decreased expression of IL6 mRNA CTD PMID:21621527 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lepr leptin receptor multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CAT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of CNTD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX15 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5A mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX5B mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6B1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of COX6C mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of FOXO3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GNA13 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HOXA9 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of IDH1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA]; astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA] CTD PMID:16964424 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Mt-nd6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of ND6 mRNA] CTD PMID:16964424 NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061
JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA1 mRNA] CTD PMID:16964424 NCBI chr  X:123,803,109...123,806,760
Ensembl chr  X:124,513,269...124,516,705
Ensembl chr  X:124,513,269...124,516,705
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFA5 mRNA] CTD PMID:16964424 NCBI chr 4:51,590,413...51,598,771
Ensembl chr 4:51,590,413...51,598,771
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFC2 mRNA] CTD PMID:16964424 NCBI chr 1:162,369,801...162,376,024
Ensembl chr 1:162,369,801...162,376,023
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NDUFV2 mRNA] CTD PMID:16964424 NCBI chr 9:113,875,718...113,900,169
Ensembl chr 9:113,875,703...113,900,190
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
EXP
ISO
astaxanthine results in increased expression of NFE2L2 protein
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NFE2L2 protein; astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [astaxanthine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]]
astaxanthine results in increased expression of NFE2L2 mRNA
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NFE2L2 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NFE2L2 mRNA
CTD PMID:20038455, PMID:23272707, PMID:24157545 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of NME2 mRNA] CTD PMID:16964424 NCBI chr10:81,648,216...81,653,717
Ensembl chr10:81,648,216...81,653,717
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
EXP
ISO
[astaxanthine co-treated with Cyclophosphamide] results in increased expression of NQO1 protein
[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of NQO1 mRNA; [astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of NQO1 mRNA
astaxanthine results in increased expression of NQO1 mRNA
astaxanthine results in increased expression of NQO1 protein
CTD PMID:20038455, PMID:24157545 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO astaxanthine results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
G Pgd phosphogluconate dehydrogenase increases activity EXP astaxanthine results in increased activity of PGD protein CTD PMID:28665548, PMID:29975440 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Por cytochrome p450 oxidoreductase decreases activity
increases expression
EXP astaxanthine results in decreased activity of POR protein
astaxanthine results in increased expression of POR protein
CTD PMID:21414371 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PPP1CB mRNA] CTD PMID:16964424 NCBI chr 6:23,548,507...23,581,136
Ensembl chr 6:23,549,317...23,581,052
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of PRDX1 mRNA] CTD PMID:16964424 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO astaxanthine results in decreased expression of PTGS2 mRNA CTD PMID:21621527 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rps2 ribosomal protein S2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of RPS2 mRNA] CTD PMID:16964424 NCBI chr10:14,088,171...14,090,020
Ensembl chr10:14,088,319...14,089,979
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression ISO astaxanthine results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 4:81,816,778...81,968,832
Ensembl chr 4:81,818,569...81,968,832
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SOD1 mRNA] CTD PMID:16964424 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions EXP [mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of and affects the localization of SP1 protein]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]; astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; astaxanthine promotes the reaction [mithramycin A inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 mRNA]]; mithramycin A promotes the reaction [astaxanthine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SP1 protein]] CTD PMID:23538867 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of SPP1 mRNA] CTD PMID:16964424 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TGM2 mRNA] CTD PMID:16964424 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Tkt transketolase multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of TKT mRNA] CTD PMID:16964424 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO astaxanthine results in decreased expression of TNF protein CTD PMID:21621527 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP astaxanthine inhibits the reaction [Cyclophosphamide results in increased expression of TP53 protein] CTD PMID:20038455 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ubb ubiquitin B multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA] CTD PMID:16964424 NCBI chr10:48,880,231...48,881,896
Ensembl chr10:48,881,049...48,881,881
JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRB mRNA] CTD PMID:16964424 NCBI chr 7:71,264,501...71,269,869
Ensembl chr 7:71,264,514...71,269,869
Ensembl chr 1:71,264,514...71,269,869
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 multiple interactions ISO astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UQCRC2 mRNA] CTD PMID:16964424 NCBI chr 1:190,555,177...190,585,741
Ensembl chr 1:190,555,177...190,585,734
JBrowse link
benfotiamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of GCLM mRNA]
benphothiamine metabolite results in increased expression of GCLM mRNA; benphothiamine results in increased expression of GCLM mRNA
CTD PMID:29860433 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [benphothiamine results in increased expression of GSR mRNA] CTD PMID:29860433 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO benphothiamine metabolite results in increased expression of HMOX1 mRNA; benphothiamine results in increased expression of HMOX1 mRNA
benphothiamine inhibits the reaction [MAPT protein results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of HMOX1 mRNA]
CTD PMID:29860433 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [benphothiamine co-treated with MAPT protein] results in decreased expression of IL1B protein CTD PMID:29860433 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mapt microtubule-associated protein tau decreases phosphorylation
multiple interactions
ISO benphothiamine results in decreased phosphorylation of MAPT protein
[benphothiamine co-treated with MAPT protein] results in decreased expression of IL1B protein; [benphothiamine co-treated with MAPT protein] results in decreased expression of NOS2 protein; [benphothiamine co-treated with MAPT protein] results in decreased expression of PTGS2 protein; [benphothiamine co-treated with MAPT protein] results in decreased expression of RELA protein; [benphothiamine co-treated with MAPT protein] results in decreased expression of TNF protein; [benphothiamine co-treated with MAPT protein] results in increased expression of NQO1 mRNA; [benphothiamine co-treated with MAPT protein] results in increased expression of TXN mRNA; benphothiamine inhibits the reaction [MAPT protein results in decreased activity of TKT protein]; benphothiamine inhibits the reaction [MAPT protein results in decreased expression of NOS2 mRNA]; benphothiamine inhibits the reaction [MAPT protein results in decreased expression of PPARGC1A protein]; benphothiamine inhibits the reaction [MAPT protein results in decreased expression of SOD1 protein]; benphothiamine inhibits the reaction [MAPT protein results in increased expression of HMOX1 mRNA]
CTD PMID:29860433 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of GSR mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of NQO1 mRNA] CTD PMID:29860433 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [benphothiamine co-treated with MAPT protein] results in decreased expression of NOS2 protein; benphothiamine inhibits the reaction [MAPT protein results in decreased expression of NOS2 mRNA] CTD PMID:29860433 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO benphothiamine metabolite results in increased expression of NQO1 mRNA; benphothiamine results in increased expression of NQO1 mRNA
[benphothiamine co-treated with MAPT protein] results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of NQO1 mRNA]
CTD PMID:29860433 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO benphothiamine inhibits the reaction [MAPT protein results in decreased expression of PPARGC1A protein] CTD PMID:29860433 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [benphothiamine co-treated with MAPT protein] results in decreased expression of PTGS2 protein CTD PMID:29860433 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [benphothiamine co-treated with MAPT protein] results in decreased expression of RELA protein CTD PMID:29860433 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO benphothiamine inhibits the reaction [MAPT protein results in decreased expression of SOD1 protein] CTD PMID:29860433 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tkt transketolase multiple interactions EXP
ISO
[benphothiamine co-treated with Streptozocin] results in increased activity of TKT protein
benphothiamine inhibits the reaction [MAPT protein results in decreased activity of TKT protein]
CTD PMID:12592403, PMID:29860433 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [benphothiamine co-treated with MAPT protein] results in decreased expression of TNF protein CTD PMID:29860433 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [benphothiamine co-treated with MAPT protein] results in increased expression of TXN mRNA CTD PMID:29860433 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
beta-carotene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acad9 acyl-CoA dehydrogenase family, member 9 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA CTD PMID:24657404 NCBI chr 2:122,782,051...122,806,166
Ensembl chr 2:122,782,060...122,805,768
JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide increases expression ISO beta Carotene results in increased expression of ADH5 mRNA CTD PMID:17034753 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO beta Carotene results in decreased expression of ADIPOQ mRNA CTD PMID:21569430 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Aebp1 AE binding protein 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA CTD PMID:24657404 NCBI chr14:86,101,253...86,111,323
Ensembl chr14:86,101,277...86,111,306
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO beta Carotene results in decreased phosphorylation of AKT1 protein CTD PMID:26733226 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions ISO beta Carotene inhibits the reaction [arsenic trioxide results in decreased expression of ALAD protein] CTD PMID:25542264 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 decreases expression ISO beta Carotene results in decreased expression of ALDH3B1 mRNA CTD PMID:17034753 NCBI chr 1:219,145,457...219,181,536
Ensembl chr 1:219,145,459...219,186,860
JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 decreases expression ISO beta Carotene results in decreased expression of ALDH4A1 mRNA CTD PMID:17034753 NCBI chr 5:158,090,238...158,115,725
Ensembl chr 5:158,042,587...158,135,733
JBrowse link
G Ank2 ankyrin 2 increases expression ISO beta Carotene results in increased expression of ANK2 mRNA CTD PMID:17034753 NCBI chr 2:231,224,643...231,522,655
Ensembl chr 2:231,226,949...231,648,122
JBrowse link
G Ank3 ankyrin 3 increases expression ISO beta Carotene results in increased expression of ANK3 mRNA CTD PMID:17034753 NCBI chr20:19,948,767...20,480,628
Ensembl chr20:20,105,047...20,480,623
JBrowse link
G Appbp2 amyloid beta precursor protein binding protein 2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA CTD PMID:24657404 NCBI chr10:72,503,347...72,545,141
Ensembl chr10:72,503,347...72,545,141
JBrowse link
G Arhgap26 Rho GTPase activating protein 26 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA CTD PMID:24657404 NCBI chr18:31,807,052...32,557,176
Ensembl chr18:31,812,109...32,207,801
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO beta Carotene results in increased expression of ASAH1 mRNA CTD PMID:17034753 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression ISO beta Carotene results in increased expression of ASB1 mRNA CTD PMID:17034753 NCBI chr 9:98,668,231...98,689,471
Ensembl chr 9:98,668,231...98,684,900
JBrowse link
G Asb9 ankyrin repeat and SOCS box-containing 9 increases expression ISO beta Carotene results in increased expression of ASB9 mRNA CTD PMID:17034753 NCBI chr  X:31,700,637...31,745,790
Ensembl chr  X:31,700,633...31,780,425
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA CTD PMID:24657404 NCBI chr18:60,013,388...60,152,920
Ensembl chr18:60,013,382...60,095,354
JBrowse link
G Bag3 BAG cochaperone 3 decreases expression ISO beta Carotene results in decreased expression of BAG3 mRNA CTD PMID:17034753 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bag4 BAG cochaperone 4 decreases expression ISO beta Carotene results in decreased expression of BAG4 mRNA CTD PMID:17034753 NCBI chr16:71,057,709...71,075,874
Ensembl chr16:71,058,022...71,075,320
JBrowse link
G Bag5 BAG cochaperone 5 decreases expression ISO beta Carotene results in decreased expression of BAG5 mRNA CTD PMID:17034753 NCBI chr 6:136,180,640...136,185,651
Ensembl chr 6:136,182,006...136,185,651
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
ISO beta Carotene results in decreased expression of BAX mRNA
beta Carotene results in increased expression of BAX mRNA; beta Carotene results in increased expression of BAX protein
CTD PMID:15949688, PMID:17034753, PMID:26733226 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO beta Carotene results in decreased expression of BCL2 protein CTD PMID:26733226 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bco1 beta-carotene oxygenase 1 multiple interactions
affects response to substance
increases oxidation
increases expression
ISO
EXP
beta Carotene results in increased expression of and results in increased activity of BCO1 protein
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA; [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA
BCO1 protein results in increased oxidation of beta Carotene
beta Carotene results in increased expression of BCO1 mRNA
Ascorbic Acid inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]; Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]; Vitamin E inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]
CTD PMID:9526112, PMID:16186334, PMID:24657404 NCBI chr19:49,637,059...49,673,577
Ensembl chr19:49,637,016...49,673,808
JBrowse link
G Bco2 beta-carotene oxygenase 2 multiple interactions
increases metabolic processing
ISO [BCO2 protein results in increased metabolism of beta Carotene] which results in increased chemical synthesis of apocarotenal CTD PMID:21106934 NCBI chr 8:54,965,577...54,990,604
Ensembl chr 8:54,965,583...54,998,864
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO alpha-Tocopherol promotes the reaction [beta Carotene metabolite results in decreased activity of CASP3 protein]
beta Carotene metabolite results in increased activity of CASP3 protein; beta Carotene results in increased activity of CASP3 protein
CTD PMID:17618090, PMID:26733226 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions EXP
ISO
[Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of CAT protein]; beta Carotene inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein]; beta Carotene inhibits the reaction [Indomethacin results in decreased expression of CAT protein]
beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein]
CTD PMID:9306888, PMID:12500499, PMID:25542264, PMID:31022331 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 decreases expression ISO beta Carotene results in decreased expression of CAV1 protein CTD PMID:26733226 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO beta Carotene results in decreased expression of CCND1 protein CTD PMID:26733226 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdca8 cell division cycle associated 8 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA CTD PMID:24657404 NCBI chr 5:142,911,310...142,933,536
Ensembl chr 5:142,911,305...142,933,526
JBrowse link
G Cdh1 cadherin 1 increases expression ISO beta Carotene results in increased expression of CDH1 mRNA; beta Carotene results in increased expression of CDH1 protein CTD PMID:17034753, PMID:26733226 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO beta Carotene results in decreased expression of CEBPA mRNA CTD PMID:21569430 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cenpe centromere protein E multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA CTD PMID:24657404 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO beta Carotene results in increased expression of CFLAR mRNA CTD PMID:17034753 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Clcn3 chloride voltage-gated channel 3 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA CTD PMID:24657404 NCBI chr16:32,448,821...32,520,649
Ensembl chr16:32,449,116...32,519,148
JBrowse link
G Cldn10 claudin 10 increases expression ISO beta Carotene results in increased expression of CLDN10 mRNA CTD PMID:17034753 NCBI chr15:104,026,590...104,115,748
Ensembl chr15:104,026,601...104,115,748
JBrowse link
G Cldn18 claudin 18 increases expression ISO beta Carotene results in increased expression of CLDN18 mRNA CTD PMID:17034753 NCBI chr 8:107,933,725...107,960,656
Ensembl chr 8:107,934,860...107,952,530
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO beta Carotene results in decreased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression ISO beta Carotene results in decreased expression of COL4A1 mRNA CTD PMID:17034753 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Col4a2 collagen type IV alpha 2 chain decreases expression ISO beta Carotene results in decreased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr16:83,386,388...83,522,169
Ensembl chr16:83,387,364...83,438,561
JBrowse link
G Coq7 coenzyme Q7, hydroxylase multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA CTD PMID:24657404 NCBI chr 1:188,176,060...188,190,874
Ensembl chr 1:188,174,874...188,190,860
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression ISO beta Carotene results in decreased expression of CPT1B mRNA CTD PMID:21569430 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain increases expression ISO beta Carotene results in increased expression of CRADD mRNA CTD PMID:17034753 NCBI chr 7:36,395,665...36,408,588
Ensembl chr 7:36,395,665...36,408,588
JBrowse link
G Ctnnal1 catenin alpha-like 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA CTD PMID:24657404 NCBI chr 5:73,561,249...73,621,070
Ensembl chr 5:73,561,450...73,621,070
JBrowse link
G Ctsb cathepsin B decreases expression ISO beta Carotene results in decreased expression of CTSB mRNA CTD PMID:17034753 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO beta Carotene results in increased expression of CXCL12 mRNA CTD PMID:17034753 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO beta Carotene results in increased expression of CXCL6 mRNA CTD PMID:17034753 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 increases expression ISO beta Carotene results in increased expression of CXCL9 mRNA CTD PMID:17034753 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO beta Carotene results in increased expression of CXCR4 mRNA CTD PMID:17034753 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]] CTD PMID:16970932 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO beta Carotene results in increased expression of CYP26A1 mRNA CTD PMID:16186334, PMID:22542753 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 increases expression ISO beta Carotene results in increased expression of CYP3A43 mRNA CTD PMID:17034753 NCBI chr12:10,636,294...10,684,273
Ensembl chr12:10,636,275...10,684,278
JBrowse link
G Dhfr dihydrofolate reductase multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA CTD PMID:24657404 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Dlx2 distal-less homeobox 2 increases expression ISO beta Carotene results in increased expression of DLX2 mRNA CTD PMID:17034753 NCBI chr 3:58,180,088...58,181,971
Ensembl chr 3:58,180,088...58,181,971
JBrowse link
G Dlx4 distal-less homeobox 4 increases expression ISO beta Carotene results in increased expression of DLX4 mRNA CTD PMID:17034753 NCBI chr10:82,958,525...82,963,919
Ensembl chr10:82,958,525...82,963,919
JBrowse link
G Dtwd2 DTW domain containing 2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA CTD PMID:24657404 NCBI chr18:43,857,371...43,945,732
Ensembl chr18:43,857,970...43,945,273
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA CTD PMID:24657404 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA CTD PMID:24657404 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression ISO beta Carotene results in decreased expression of ERCC2 mRNA CTD PMID:17034753 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR1 protein]; beta Carotene inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA] CTD PMID:17051425, PMID:19340624 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; beta Carotene inhibits the reaction [Genistein results in increased activity of ESR2 protein] CTD PMID:17051425 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO beta Carotene results in decreased expression of FABP4 mRNA CTD PMID:21569430 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 increases expression ISO beta Carotene results in increased expression of FAIM2 mRNA CTD PMID:17034753 NCBI chr 7:141,158,769...141,185,781
Ensembl chr 7:141,157,963...141,185,710
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO beta Carotene results in increased expression of FAS mRNA CTD PMID:17034753 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO beta Carotene results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Foxa1 forkhead box A1 increases expression ISO beta Carotene results in increased expression of FOXA1 mRNA CTD PMID:17034753 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G Foxm1 forkhead box M1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA CTD PMID:24657404 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305
JBrowse link
G Fzd6 frizzled class receptor 6 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA CTD PMID:24657404 NCBI chr 7:77,898,329...77,931,034
Ensembl chr 7:77,899,322...77,931,029
JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO beta Carotene results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Gbp1 guanylate binding protein 1 increases expression ISO beta Carotene results in increased expression of GBP1 mRNA CTD PMID:17034753 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases expression
ISO
EXP
beta Carotene promotes the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]; Ro 41-5253 inhibits the reaction [beta Carotene results in increased expression of GJA1 protein]
beta Carotene inhibits the reaction [Hydrogen Peroxide results in decreased expression of GJA1 mRNA]; beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GJA1 protein]
CTD PMID:16091010, PMID:27154496 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO beta Carotene inhibits the reaction [arsenic trioxide results in decreased activity of GSR protein] CTD PMID:25542264 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression ISO beta Carotene results in decreased expression of GSTK1 mRNA CTD PMID:17034753 NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO beta Carotene results in increased expression of GSTM2 mRNA CTD PMID:17034753 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm3l glutathione S-transferase mu 3-like increases expression ISO beta Carotene results in increased expression of GSTM5 mRNA CTD PMID:17034753 NCBI chr 2:210,761,729...210,766,501
Ensembl chr 2:210,761,729...210,766,501
JBrowse link
G Gstm4 glutathione S-transferase mu 4 decreases expression ISO beta Carotene results in decreased expression of GSTM4 mRNA CTD PMID:17034753 NCBI chr 2:210,834,013...210,839,242
Ensembl chr 2:210,833,884...210,839,295
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 decreases expression ISO beta Carotene results in decreased expression of GSTZ1 mRNA CTD PMID:17034753 NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244
JBrowse link
G Hoxa7 homeobox A7 increases expression ISO beta Carotene results in increased expression of HOXA7 mRNA CTD PMID:17034753 NCBI chr 4:82,184,299...82,187,890
Ensembl chr 4:82,183,196...82,186,190
JBrowse link
G Hoxb6 homeo box B6 increases expression ISO beta Carotene results in increased expression of HOXB6 mRNA CTD PMID:17034753 NCBI chr10:84,147,331...84,150,238
Ensembl chr10:84,147,836...84,149,600
JBrowse link
G Hoxc10 homeo box C10 increases expression ISO beta Carotene results in increased expression of HOXC10 mRNA CTD PMID:17034753 NCBI chr 7:144,577,578...144,582,802
Ensembl chr 7:144,577,465...144,582,622
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions EXP beta Carotene inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of HPRT1 gene] CTD PMID:12467141 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 multiple interactions EXP [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of IGFBP5 mRNA CTD PMID:23859036 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of IL1B protein]] CTD PMID:21447443 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Irf8 interferon regulatory factor 8 increases expression ISO beta Carotene results in increased expression of IRF8 mRNA CTD PMID:17034753 NCBI chr19:54,314,859...54,336,643
Ensembl chr19:54,314,865...54,336,640
JBrowse link
G Irx4 iroquois homeobox 4 decreases expression
multiple interactions
ISO beta Carotene results in decreased expression of IRX4 mRNA
[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA
CTD PMID:17034753, PMID:24657404 NCBI chr 1:32,634,774...32,645,151
Ensembl chr 1:32,634,796...32,643,771
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO beta Carotene results in decreased expression of ITGB1 mRNA CTD PMID:17034753 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO beta Carotene results in decreased expression of ITGB4 mRNA CTD PMID:17034753 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Itm2a integral membrane protein 2A multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA CTD PMID:24657404 NCBI chr  X:78,490,872...78,496,814
Ensembl chr  X:78,490,866...78,496,847
JBrowse link
G Ivl involucrin increases expression ISO beta Carotene results in increased expression of IVL mRNA CTD PMID:17034753 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO beta Carotene results in increased expression of JUN protein CTD PMID:20025956 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kif11 kinesin family member 11 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA CTD PMID:24657404 NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299
JBrowse link
G Krt18 keratin 18 increases expression ISO beta Carotene results in increased expression of KRT18 mRNA CTD PMID:17034753 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt19 keratin 19 increases expression ISO beta Carotene results in increased expression of KRT19 mRNA CTD PMID:17034753 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Krt2 keratin 2 increases expression ISO beta Carotene results in increased expression of KRT2 mRNA CTD PMID:17034753 NCBI chr 7:143,412,858...143,420,463
Ensembl chr 7:143,412,858...143,420,027
JBrowse link
G Krt7 keratin 7 affects expression ISO beta Carotene affects the expression of KRT7 mRNA CTD PMID:17034753 NCBI chr 7:143,059,731...143,075,907
Ensembl chr 7:143,059,764...143,075,907
JBrowse link
G Krt8 keratin 8 decreases expression ISO beta Carotene results in decreased expression of KRT8 mRNA CTD PMID:17034753 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lancl1 LanC like 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA CTD PMID:24657404 NCBI chr 9:74,018,192...74,048,098
Ensembl chr 9:74,014,656...74,048,244
JBrowse link
G Lhx3 LIM homeobox 3 increases expression ISO beta Carotene results in increased expression of LHX3 mRNA CTD PMID:17034753 NCBI chr 3:3,653,861...3,662,509
Ensembl chr 3:3,654,755...3,661,810
JBrowse link
G Lmnb2 lamin B2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA CTD PMID:24657404 NCBI chr 7:11,657,870...11,676,936
Ensembl chr 7:11,660,934...11,675,472
JBrowse link
G Lpl lipoprotein lipase decreases expression ISO beta Carotene results in decreased expression of LPL mRNA CTD PMID:21569430 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
beta Carotene results in increased phosphorylation of MAPK1 protein
beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]
CTD PMID:16206275, PMID:27154496 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
beta Carotene results in increased phosphorylation of MAPK3 protein
beta Carotene inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]
CTD PMID:16206275, PMID:27154496 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mbl2 mannose binding lectin 2 multiple interactions ISO MBL2 gene polymorphism affects the susceptibility to [Vitamin A co-treated with beta Carotene] CTD PMID:16960176 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects expression ISO beta Carotene affects the expression of MCL1 mRNA CTD PMID:17034753 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Meis2 Meis homeobox 2 increases expression ISO beta Carotene results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr 3:107,560,172...107,762,732
Ensembl chr 3:107,559,997...107,760,589
JBrowse link
G Meox1 mesenchyme homeobox 1 increases expression ISO beta Carotene results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr10:89,797,011...89,817,009
Ensembl chr10:89,797,038...89,816,491
JBrowse link
G Mettl21a methyltransferase like 21A multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA CTD PMID:24657404 NCBI chr 9:71,304,138...71,314,015
Ensembl chr 9:71,304,427...71,313,940
JBrowse link
G Mettl9 methyltransferase like 9 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA CTD PMID:24657404 NCBI chr 1:190,962,935...191,009,926
Ensembl chr 1:190,964,885...191,009,926
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase affects response to substance ISO MGMT gene SNP affects the susceptibility to beta Carotene CTD PMID:16014702 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of MKI67 mRNA CTD PMID:23859036 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mnx1 motor neuron and pancreas homeobox 1 increases expression ISO beta Carotene results in increased expression of MNX1 mRNA CTD PMID:17034753 NCBI chr 4:2,376,350...2,381,308
Ensembl chr 4:2,376,958...2,381,271
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [Ascorbic Acid co-treated with beta Carotene co-treated with alpha-Tocopherol co-treated with Sodium Selenite] inhibits the reaction [Galactosamine results in increased activity of MPO protein] CTD PMID:31022331 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mrpl57 mitochondrial ribosomal protein L57 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA CTD PMID:24657404 NCBI chr15:38,096,994...38,097,856
Ensembl chr15:38,095,803...38,097,835
JBrowse link
G Msh5 mutS homolog 5 increases expression ISO beta Carotene results in increased expression of MSH5 mRNA CTD PMID:17034753 NCBI chr20:5,020,690...5,037,125
Ensembl chr20:5,020,667...5,037,088
JBrowse link
G Mtch2 mitochondrial carrier 2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA CTD PMID:24657404 NCBI chr 3:79,678,141...79,695,356
Ensembl chr 3:79,678,201...79,694,006
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression ISO beta Carotene results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nckap1 NCK-associated protein 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA CTD PMID:24657404 NCBI chr 3:67,725,180...67,804,680
Ensembl chr 3:67,725,947...67,787,990
JBrowse link
G Nom1 nucleolar protein with MIF4G domain 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA CTD PMID:24657404 NCBI chr 4:2,340,034...2,356,427
Ensembl chr 4:2,340,148...2,356,068
JBrowse link
G Nos1 nitric oxide synthase 1 increases expression ISO beta Carotene results in increased expression of NOS1 mRNA CTD PMID:17034753 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in increased expression of NOS2 mRNA] CTD PMID:18779489 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]
beta Carotene results in increased activity of NR1I2 protein
CTD PMID:15949683, PMID:16632523 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO beta Carotene results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Pard6a par-6 family cell polarity regulator alpha multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA CTD PMID:24657404 NCBI chr19:37,668,133...37,670,450
Ensembl chr19:37,668,133...37,672,729
JBrowse link
G Pcdh1 protocadherin 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA CTD PMID:24657404 NCBI chr18:31,330,081...31,343,147
Ensembl chr18:31,328,919...31,343,797
JBrowse link
G Pcdhgc3 protocadherin gamma subfamily C, 3 increases expression ISO beta Carotene results in increased expression of PCDHGC3 mRNA CTD PMID:17034753 NCBI chr18:30,954,552...30,971,113
Ensembl chr18:30,913,842...30,969,361
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA; [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein CTD PMID:23859036 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO beta Carotene results in increased expression of PIK3R5 protein CTD PMID:20025956 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA CTD PMID:24657404 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plscr1 phospholipid scramblase 1 increases expression ISO beta Carotene results in increased expression of PLSCR1 mRNA CTD PMID:17034753 NCBI chr 8:99,625,523...99,645,882
Ensembl chr 8:99,625,545...99,725,217
JBrowse link
G Plscr3 phospholipid scramblase 3 increases expression ISO beta Carotene results in increased expression of PLSCR3 mRNA CTD PMID:17034753 NCBI chr10:56,452,632...56,458,390
Ensembl chr10:56,453,877...56,458,390
JBrowse link
G Plscr4 phospholipid scramblase 4 increases expression ISO beta Carotene results in increased expression of PLSCR4 mRNA CTD PMID:17034753 NCBI chr 8:99,880,073...99,917,733
Ensembl chr 8:99,880,073...99,918,825
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO beta Carotene results in decreased expression of PPARA mRNA CTD PMID:21569430 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO beta Carotene results in decreased expression of PPARG mRNA CTD PMID:21569430 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Rad51ap1 RAD51 associated protein 1 decreases expression ISO beta Carotene results in decreased expression of RAD51AP1 mRNA CTD PMID:17034753 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869
JBrowse link
G Rad51d RAD51 paralog D increases expression ISO beta Carotene results in increased expression of RAD51D mRNA CTD PMID:17034753 NCBI chr10:70,222,703...70,241,352
Ensembl chr10:70,227,163...70,241,254
JBrowse link
G Rara retinoic acid receptor, alpha decreases expression ISO beta Carotene results in decreased expression of RARA mRNA CTD PMID:17034753 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO beta Carotene results in increased expression of RARB mRNA CTD PMID:17034753 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression ISO beta Carotene results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 2:164,650,722...164,684,982
Ensembl chr 2:164,650,722...164,684,985
JBrowse link
G Rbp4 retinol binding protein 4 multiple interactions ISO beta Carotene results in decreased expression of and results in decreased secretion of RBP4 protein CTD PMID:22542753 NCBI chr 1:256,806,476...256,813,678
Ensembl chr 1:256,806,472...256,813,711
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases phosphorylation ISO beta Carotene results in decreased phosphorylation of RELA protein CTD PMID:26733226 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rpp14 ribonuclease P/MRP subunit p14 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA CTD PMID:24657404 NCBI chr15:18,625,963...18,636,157
Ensembl chr15:18,625,964...18,632,536
JBrowse link
G Rrm1 ribonucleotide reductase catalytic subunit M1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA CTD PMID:24657404 NCBI chr 1:167,538,387...167,562,688
Ensembl chr 1:167,538,263...167,562,688
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases transport ISO SCARB1 protein results in increased transport of beta Carotene CTD PMID:16177187 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Six6 SIX homeobox 6 increases expression ISO beta Carotene results in increased expression of SIX6 mRNA CTD PMID:17034753 NCBI chr 6:95,816,749...95,821,729
Ensembl chr 6:95,816,749...95,821,729
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression ISO beta Carotene results in decreased expression of SLC2A4 mRNA CTD PMID:21569430 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO beta Carotene results in decreased expression of SOD1 mRNA CTD PMID:17034753 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of SOD2 mRNA; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 mRNA]; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein] CTD PMID:18779489, PMID:23859036 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 affects expression ISO beta Carotene affects the expression of SPTLC2 mRNA CTD PMID:17034753 NCBI chr 6:111,334,408...111,417,960
Ensembl chr 6:111,339,136...111,417,954
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO beta Carotene results in increased expression of SREBF1 mRNA CTD PMID:17034753 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tfcp2 transcription factor CP2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA CTD PMID:24657404 NCBI chr 7:142,138,836...142,181,036
Ensembl chr 7:142,138,844...142,180,997
JBrowse link
G Tgm2 transglutaminase 2 increases expression ISO beta Carotene results in increased expression of TGM2 mRNA CTD PMID:17034753 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Tgm4 transglutaminase 4 increases expression ISO beta Carotene results in increased expression of TGM4 mRNA CTD PMID:17034753 NCBI chr 8:132,117,279...132,157,485
Ensembl chr 8:132,120,452...132,157,485
JBrowse link
G Thoc7 THO complex 7 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA CTD PMID:24657404 NCBI chr15:12,569,235...12,584,101
Ensembl chr15:12,569,235...12,584,094
JBrowse link
G Tmem209 transmembrane protein 209 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA CTD PMID:24657404 NCBI chr 4:57,796,337...57,823,283
Ensembl chr 4:57,796,338...57,823,295
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]; beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]; Quercetin affects the reaction [beta Carotene affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]]; Quercetin inhibits the reaction [beta Carotene promotes the reaction [Benzo(a)pyrene results in increased secretion of TNF protein]]
beta Carotene promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:19135038, PMID:21447443 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 increases expression ISO beta Carotene results in increased expression of TNFRSF9 mRNA CTD PMID:17034753 NCBI chr 5:168,009,245...168,035,813
Ensembl chr 5:168,009,393...168,035,810
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO beta Carotene results in increased expression of TNFSF10 mRNA CTD PMID:17034753 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Ttc21b tetratricopeptide repeat domain 21B multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA CTD PMID:24657404 NCBI chr 3:52,286,794...52,361,060
Ensembl chr 3:52,286,794...52,361,060
JBrowse link
G Twf1 twinfilin actin-binding protein 1 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA CTD PMID:24657404 NCBI chr 7:135,838,647...135,850,542
Ensembl chr 7:135,838,648...135,850,542
JBrowse link
G Txndc9 thioredoxin domain containing 9 increases expression ISO beta Carotene results in increased expression of TXNDC9 mRNA CTD PMID:17034753 NCBI chr 9:44,647,707...44,657,779
Ensembl chr 9:44,647,707...44,657,779
JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA CTD PMID:24657404 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 increases expression ISO beta Carotene results in increased expression of XRCC3 mRNA CTD PMID:17034753 NCBI chr 6:136,366,917...136,380,751
Ensembl chr 6:136,371,555...136,379,348
JBrowse link
G Ythdc2 YTH domain containing 2 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA CTD PMID:24657404 NCBI chr 1:182,072,386...182,141,399
Ensembl chr 1:182,085,899...182,140,570
JBrowse link
G Zdhhc3 zinc finger DHHC-type palmitoyltransferase 3 multiple interactions ISO [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA CTD PMID:24657404 NCBI chr 8:132,156,216...132,204,484
Ensembl chr 8:132,160,172...132,189,388
JBrowse link
canthaxanthin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO
EXP
Canthaxanthin results in increased expression of CYP1A1 mRNA CTD PMID:9271336 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP
ISO
Canthaxanthin results in increased expression of CYP1A2 mRNA CTD PMID:9271336 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
lutein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of ALS2 mRNA; [Cisplatin co-treated with Lutein] results in increased expression of ALS2 mRNA
Lutein results in decreased expression of ALS2 mRNA
CTD PMID:24865317 NCBI chr 9:65,961,361...66,034,396
Ensembl chr 9:65,961,346...66,033,871
JBrowse link
G Apc APC regulator of WNT signaling pathway multiple interactions ISO [Cisplatin co-treated with Lutein] results in increased expression of APC mRNA CTD PMID:24865317 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Aqr aquarius intron-binding spliceosomal factor decreases expression
multiple interactions
ISO Lutein results in decreased expression of AQR mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of AQR mRNA
CTD PMID:24865317 NCBI chr 3:105,570,399...105,640,431
Ensembl chr 3:105,570,292...105,640,463
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of ATR mRNA
Lutein results in decreased expression of ATR mRNA
CTD PMID:24865317 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Lutein results in increased expression of BAX protein CTD PMID:17455471 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Lutein results in decreased expression of BCL2 protein CTD PMID:17455471 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO Lutein results in increased expression of BCL2L1 protein CTD PMID:10750663 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bco2 beta-carotene oxygenase 2 increases metabolic processing
affects metabolic processing
multiple interactions
ISO BCO2 protein results in increased metabolism of Lutein
BCO2 protein affects the metabolism of Lutein
[BCO2 protein affects the metabolism of Lutein] which results in increased abundance of 3'-dehydrolutein; [BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite
CTD PMID:21106934 NCBI chr 8:54,965,577...54,990,604
Ensembl chr 8:54,965,583...54,998,864
JBrowse link
G Cat catalase multiple interactions ISO Lutein inhibits the reaction [deoxynivalenol results in increased expression of CAT protein] CTD PMID:20347963 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Lutein results in decreased expression of CCND1 protein CTD PMID:17718427 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccs copper chaperone for superoxide dismutase increases expression ISO Lutein results in increased expression of CCS mRNA CTD PMID:24865317 NCBI chr 1:220,075,251...220,096,319
Ensembl chr 1:220,075,247...220,096,404
JBrowse link
G Cfd complement factor D decreases expression
decreases secretion
ISO Lutein results in decreased expression of CFD mRNA
Lutein results in decreased secretion of CFD protein
CTD PMID:26504594 NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943
JBrowse link
G Ctsb cathepsin B increases expression
multiple interactions
ISO Lutein results in increased expression of CTSB mRNA
Cisplatin inhibits the reaction [Lutein results in increased expression of CTSB mRNA]
CTD PMID:24865317 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of CYBA mRNA
Lutein results in decreased expression of CYBA mRNA
CTD PMID:24865317 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression
multiple interactions
ISO Lutein results in decreased expression of ERCC2 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of ERCC2 mRNA
CTD PMID:24865317 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor decreases expression ISO Lutein results in decreased expression of ERCC6 mRNA CTD PMID:24865317 NCBI chr16:8,734,028...8,804,610
Ensembl chr16:8,734,035...8,804,610
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 decreases expression ISO Lutein results in decreased expression of FMO2 mRNA CTD PMID:24865317 NCBI chr13:80,752,526...80,775,264
Ensembl chr13:80,755,058...80,775,264
JBrowse link
G Gab1 GRB2-associated binding protein 1 decreases expression
multiple interactions
ISO Lutein results in decreased expression of GAB1 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of GAB1 mRNA
CTD PMID:24865317 NCBI chr19:30,794,290...30,903,819
Ensembl chr19:30,794,571...30,902,008
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression
ISO Cisplatin inhibits the reaction [Lutein results in increased expression of GPX1 mRNA]; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of GPX1 mRNA] CTD PMID:22040935, PMID:24865317 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [Lutein co-treated with Cisplatin] results in increased expression of GPX2 mRNA CTD PMID:24865317 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO [Cisplatin co-treated with Lutein] results in decreased expression of GPX3 mRNA CTD PMID:24865317 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions
ISO Lutein results in increased expression of GSR mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of GSR mRNA
CTD PMID:24865317 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 multiple interactions ISO [Cisplatin co-treated with Lutein] results in decreased expression of GSTK1 mRNA CTD PMID:24865317 NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO arsenic trioxide promotes the reaction [Lutein results in increased expression of HMOX1 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of HMOX1 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]
Lutein results in increased expression of HMOX1 mRNA; Lutein results in increased expression of HMOX1 protein
CTD PMID:25815309, PMID:26187899 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of IDH1 mRNA
Lutein results in decreased expression of IDH1 mRNA
CTD PMID:24865317 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Ift172 intraflagellar transport 172 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of IFT172 mRNA
Lutein results in decreased expression of IFT172 mRNA
CTD PMID:24865317 NCBI chr 6:26,390,686...26,485,459 JBrowse link
G Kif9 kinesin family member 9 multiple interactions
increases expression
ISO Lutein promotes the reaction [Cisplatin results in decreased expression of KIF9 mRNA]
Lutein results in increased expression of KIF9 mRNA
CTD PMID:24865317 NCBI chr 8:118,737,739...118,795,190
Ensembl chr 8:118,744,229...118,794,992
JBrowse link
G Mb myoglobin increases expression ISO Lutein results in increased expression of MB mRNA CTD PMID:24865317 NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 multiple interactions
increases expression
ISO arsenic trioxide promotes the reaction [Lutein results in increased expression of MGST1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of MGST1 mRNA] CTD PMID:25815309, PMID:26187899 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO arsenic trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 protein]; Lutein results in increased expression of and affects the localization of NFE2L2 protein
Lutein results in increased expression of NFE2L2 mRNA; Lutein results in increased expression of NFE2L2 protein
CTD PMID:25815309, PMID:26187899 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ngb neuroglobin increases expression ISO Lutein results in increased expression of NGB mRNA CTD PMID:24865317 NCBI chr 6:111,126,259...111,131,699
Ensembl chr 6:111,126,261...111,132,320
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of NOX4 mRNA
Lutein results in decreased expression of NOX4 mRNA
CTD PMID:24865317 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Noxo1 NADPH oxidase organizer 1 multiple interactions ISO [Cisplatin co-treated with Lutein] results in decreased expression of NOXO1 mRNA CTD PMID:24865317 NCBI chr10:14,062,331...14,066,918
Ensembl chr10:14,062,331...14,066,918
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO [Cisplatin co-treated with Lutein] results in increased expression of NQO1 mRNA; arsenic trioxide promotes the reaction [Lutein results in increased expression of NQO1 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of NQO1 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NQO1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NQO1 protein]
Lutein results in increased expression of NQO1 mRNA; Lutein results in increased expression of NQO1 protein
CTD PMID:24865317, PMID:25815309, PMID:26187899 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nudt15 nudix hydrolase 15 decreases expression
multiple interactions
ISO Lutein results in decreased expression of NUDT15 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of NUDT15 mRNA
CTD PMID:24865317 NCBI chr15:55,417,774...55,456,698
Ensembl chr15:55,419,502...55,456,698
JBrowse link
G Nxn nucleoredoxin increases expression
multiple interactions
ISO Lutein results in increased expression of NXN mRNA
Lutein inhibits the reaction [Cisplatin results in increased expression of NXN mRNA]
CTD PMID:24865317 NCBI chr10:64,411,710...64,550,147
Ensembl chr10:64,412,833...64,550,145
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO [Cisplatin co-treated with Lutein] results in decreased expression of PARK7 mRNA CTD PMID:24865317 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of PPP1R15B mRNA
Lutein results in decreased expression of PPP1R15B mRNA
CTD PMID:24865317 NCBI chr13:49,933,155...49,940,961
Ensembl chr13:49,933,155...49,940,961
JBrowse link
G Prdx4 peroxiredoxin 4 increases expression ISO Lutein results in increased expression of PRDX4 mRNA CTD PMID:24865317 NCBI chr  X:43,495,453...43,512,994
Ensembl chr  X:43,497,763...43,512,991
JBrowse link
G Prdx5 peroxiredoxin 5 decreases expression ISO Lutein results in decreased expression of PRDX5 mRNA CTD PMID:24865317 NCBI chr 1:222,164,462...222,167,447
Ensembl chr 1:222,164,462...222,167,447
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of PRDX6 mRNA
Lutein results in decreased expression of PRDX6 mRNA
CTD PMID:24865317 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [Cisplatin co-treated with Lutein] results in decreased expression of PTGS1 mRNA CTD PMID:24865317 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Lutein inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein] CTD PMID:20347963 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Lutein inhibits the reaction [deoxynivalenol affects the localization of RELA protein]; Lutein inhibits the reaction [deoxynivalenol results in increased expression of RELA protein] CTD PMID:20347963 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of SCD1 mRNA
Lutein results in decreased expression of SCD1 mRNA
CTD PMID:24865317 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
ISO Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD1 mRNA]
Lutein results in increased expression of SOD1 mRNA
CTD PMID:22040935, PMID:24865317 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of SOD2 mRNA; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD2 mRNA]
Lutein results in decreased expression of SOD2 mRNA
CTD PMID:22040935, PMID:24865317 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of SOD3 mRNA
Lutein results in decreased expression of SOD3 mRNA
CTD PMID:24865317 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions
decreases expression
ISO [Cisplatin co-treated with Lutein] results in decreased expression of SRXN1 mRNA
Lutein results in decreased expression of SRXN1 mRNA
CTD PMID:24865317 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression
multiple interactions
ISO Lutein results in decreased expression of TXNRD1 mRNA
[Cisplatin co-treated with Lutein] results in decreased expression of TXNRD1 mRNA
CTD PMID:24865317 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ucp3 uncoupling protein 3 increases expression ISO Lutein results in increased expression of UCP3 mRNA CTD PMID:24865317 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link
G Vim vimentin increases expression ISO Lutein results in increased expression of VIM mRNA CTD PMID:24865317 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Xirp1 xin actin-binding repeat containing 1 increases expression ISO Lutein results in increased expression of XIRP1 mRNA CTD PMID:24865317 NCBI chr 8:128,694,809...128,712,092
Ensembl chr 8:128,702,133...128,711,221
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        provitamin 250
          doxercalciferol 0
          pantothenol 0
          provitamin A + 246
          provitamin B1 + 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.