Term: | cefiderocol |
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Accession: | CHEBI:140376
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Definition: | A fourth-generation siderophore cephalosporin antibiotic having {1-[2-(2-chloro-3,4-dihydroxybenzamido)ethyl]pyrrolidinium-1-yl}methyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino side groups located at positions 3 and 7 respectively, developed to combat a variety of bacterial pathogens, including beta-lactam- and carbapenem-resistant organisms. |
Synonyms: | exact_synonym: | (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-({1-[2-(2-chloro-3,4-dihydroxybenzamido)ethyl]pyrrolidinium-1-yl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| related_synonym: | Formula=C30H34ClN7O10S2; GSK-2696266; GSK2696266; InChI=1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1; InChIKey=DBPPRLRVDVJOCL-FQRUVTKNSA-N; RSC 649266; S-649266; S649266; SMILES=[H][C@]12SCC(C[N+]3(CCNC(=O)C4=CC=C(O)C(O)=C4Cl)CCCC3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC(C)(C)C(O)=O)\\C1=CSC(N)=N1)C([O-])=O; cefiderocolum |
| xref: | CAS:1225208-94-5; Chemspider:52084902; DrugBank:DB14879; Drug_Central:5352; KEGG:D11302; PMCID:PMC6253113; PMCID:PMC7776597; PMCID:PMC7777002; PMID:27139465; PMID:28369471; PMID:28748397; PMID:28848004; PMID:29017833; PMID:29061741; PMID:29111435; PMID:29311072; PMID:29318906; PMID:29471305; PMID:29960205; PMID:30323050; PMID:30730562; PMID:32522005; PMID:32727829; PMID:33068441; PMID:33164837; PMID:33199383; PMID:33313656; PMID:33393598; PMID:33532823; PMID:33573148; PMID:33670891; PMID:33677539; PMID:33849355; PMID:33894839; PMID:33915286; Patent:EP2341053; Reaxys:21605074; Wikipedia:Cefiderocol |
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