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pimasertib - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pimasertib
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Accession:CHEBI:94793 term browser browse the term
Definition:A secondary carboxamide resulting from the formal condensation of the carboxy group of 3-(2-fluoro-4-iodoanilino)pyridine-4-carboxylic acid with the amino group of (2S)-3-aminopropane-1,2-diol. It is a potent inhibitor of the mitogen-activated protein kinases MEK1 and MEK2 with potential antineoplastic activity.
Synonyms:exact_synonym: N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamide
 related_synonym: AS-703026;   AS703026;   Formula=C15H15FIN3O3;   InChI=1S/C15H15FIN3O3/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21/h1-5,7,10,20-22H,6,8H2,(H,19,23)/t10-/m0/s1;   InChIKey=VIUAUNHCRHHYNE-JTQLQIEISA-N;   MSC 1936369B;   MSC-1236369B;   MSC1936369B;   N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)-4-pyridinecarboxamide;   SAR-245509;   SAR245509;   SMILES=OC[C@@H](O)CNC(=O)C1=C(NC2=C(F)C=C(I)C=C2)C=NC=C1;   pimasertibum
 xref: CAS:1236699-92-5;   DrugBank:DB14904;   KEGG:D10426;   LINCS:LSM-5946;   PDBeChem:QOA;   PMID:20331454;   PMID:24051957;   PMID:25989270;   PMID:26033306;   PMID:26381508;   PMID:26444523;   PMID:26640591;   PMID:26657199;   PMID:26924269;   PMID:26961147;   PMID:27179113;   PMID:27179114;   PMID:27483391;   PMID:27934635;   PMID:28151716;   PMID:28194539;   PMID:28289865;   PMID:29338133;   PMID:29488172;   PMID:29756206;   PMID:30425349;   PMID:30585255;   PMID:30848427;   PMID:31482223;   PMID:31586300;   PMID:31870556;   PMID:32610581;   PMID:33170484;   PMID:33211315;   PMID:34470822;   PMID:37097377

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Path 1
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  CHEBI ontology 0
    role 0
      biological role 0
        biochemical role 0
          apoptosis inducer 0
            pimasertib 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 0
    subatomic particle 0
      composite particle 0
        hadron 0
          baryon 0
            nucleon 0
              atomic nucleus 0
                atom 0
                  main group element atom 0
                    p-block element atom 0
                      carbon group element atom 0
                        carbon atom 0
                          organic molecular entity 0
                            heteroorganic entity 0
                              organochalcogen compound 0
                                organooxygen compound 0
                                  carbon oxoacid 0
                                    carboxylic acid 0
                                      carboacyl group 0
                                        univalent carboacyl group 0
                                          carbamoyl group 0
                                            carboxamide 0
                                              secondary carboxamide 0
                                                pimasertib 0
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