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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:vorinostat
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Accession:CHEBI:45716 term browser browse the term
Definition:A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Synonyms:exact_synonym: N-hydroxy-N'-phenyloctanediamide
 related_synonym: Formula=C14H20N2O3;   InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18);   InChIKey=WAEXFXRVDQXREF-UHFFFAOYSA-N;   SAHA;   SHH;   SMILES=ONC(=O)CCCCCCC(=O)Nc1ccccc1;   Suberanilohydroxamic acid;   Zolinza;   octanedioic acid hydroxyamide phenylamide;   suberoylanilide hydroxamic acid;   vorinostatum
 xref: CAS:149647-78-9;   DrugBank:DB02546;   Drug_Central:4124;   HMDB:HMDB0015568;   KEGG:D06320;   LINCS:LSM-3828
 xref_mesh: MESH:C111237
 xref: PDBeChem:SHH;   PMID:21657958;   PMID:22887890;   PMID:23320102;   PMID:23348693;   PMID:23708756;   PMID:23758082;   PMID:23820962;   PMID:23864881;   Patent:CN102641261;   Patent:KR20110045493;   Patent:NZ592686;   Patent:US2011039937;   Patent:WO2008106524;   Reaxys:7213017;   Wikipedia:Vorinostat


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vorinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASQ1 calsequestrin 1 decreases expression EXP Vorinostat results in decreased expression of CASQ1 mRNA CTD PMID:27255383 NCBI chr38:22,012,060...22,020,430
Ensembl chr38:22,011,060...22,020,383 		JBrowse link
G HSP70 heat shock protein 70 decreases expression EXP Vorinostat results in decreased expression of HSP70 mRNA CTD PMID:27255383 NCBI chr12:1,285,282...1,287,670 JBrowse link
G TNNI3K TNNI3 interacting kinase decreases expression EXP Vorinostat results in decreased expression of TNNI3K mRNA CTD PMID:27255383 NCBI chr 6:71,825,853...72,107,832
Ensembl chr 6:71,815,734...72,119,476 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 495
    role 495
      biological role 495
        biochemical role 455
          apoptosis inducer 116
            vorinostat 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 495
    subatomic particle 495
      composite particle 495
        hadron 495
          baryon 495
            nucleon 495
              atomic nucleus 495
                atom 495
                  main group element atom 488
                    p-block element atom 488
                      carbon group element atom 477
                        carbon atom 476
                          organic molecular entity 476
                            heteroorganic entity 472
                              organochalcogen compound 426
                                organooxygen compound 424
                                  carbon oxoacid 365
                                    carboxylic acid 365
                                      carboacyl group 306
                                        univalent carboacyl group 306
                                          carbamoyl group 304
                                            carboxamide 304
                                              dicarboxylic acid amide 4
                                                dicarboxylic acid diamide 3
                                                  vorinostat 3
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