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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cefadroxil
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Accession:CHEBI:3479 term browser browse the term
Definition:A cephalosporin bearing methyl and (2R)-2-amino-2-(4-hydroxyphenyl)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton.
Synonyms:exact_synonym: 7beta-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-3,4-didehydrocepham-4-carboxylic acid
 related_synonym: (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;   CDX;   Cefadroxil anhydrous;   Cephadroxil;   D-Cefadroxil;   Formula=C16H17N3O5S;   InChI=1S/C16H17N3O5S/c1-7-6-25-15-11(14(22)19(15)12(7)16(23)24)18-13(21)10(17)8-2-4-9(20)5-3-8/h2-5,10-11,15,20H,6,17H2,1H3,(H,18,21)(H,23,24)/t10-,11-,15-/m1/s1;   InChIKey=BOEGTKLJZSQCCD-UEKVPHQBSA-N;   SMILES=[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)c1ccc(O)cc1)C(O)=O;   cefadroxilo;   cefadroxilum
 xref: Beilstein:5933893;   CAS:50370-12-2;   DrugBank:DB01140;   Drug_Central:526;   KEGG:C06878;   KEGG:D00257;   LINCS:LSM-5722
 xref_mesh: MESH:D002434
 xref: PMID:12833570;   PMID:21425867;   PMID:23224978;   PMID:23959853;   PMID:24080658;   PMID:24412692;   PMID:24667741;   PMID:29017833;   PMID:9131470;   Patent:DE2216113;   Patent:NL6812382;   Patent:US3489752;   Patent:US3816253;   Reaxys:5393893;   Wikipedia:Cefadroxil
 cyclic_relationship: is_conjugate_acid_of CHEBI:53669


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cefadroxil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Cefadroxil results in increased expression of CYP3A4 mRNA; Cefadroxil results in increased expression of CYP3A4 protein CTD PMID:18505790 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Cefadroxil affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        antimicrobial agent 18273
          antibacterial agent 16370
            antibacterial drug 7392
              cefadroxil 2
                cefadroxil monohydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            heteroorganic entity 19558
                              organochalcogen compound 19317
                                organooxygen compound 19233
                                  carbon oxoacid 18695
                                    carboxylic acid 18692
                                      carboacyl group 17724
                                        univalent carboacyl group 17724
                                          carbamoyl group 17577
                                            carboxamide 17577
                                              lactam 8394
                                                beta-lactam 831
                                                  beta-lactam antibiotic 816
                                                    cephem 551
                                                      cephalosporin 550
                                                        cefadroxil 2
                                                          cefadroxil monohydrate 0
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