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dynasore - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dynasore
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Accession:CHEBI:132754 term browser browse the term
Definition:A carbohydrazide resulting from the formal condensation of the hydrazone moiety of 3,4-dihydroxybenzaldehyde hydrazone with the carboxy group of 3-hydroxy-2-naphthoic acid. It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity of dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42.
Synonyms:exact_synonym: N'-[(E)-(3,4-dihydroxyphenyl)methylene]-3-hydroxy-2-naphthohydrazide
 related_synonym: 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide;   Dynamin Inhibitor I;   Formula=C18H14N2O4;   InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+;   InChIKey=SYNDQCRDGGCQRZ-VXLYETTFSA-N;   SMILES=C=1C2=C(C=CC1)C=C(C(=C2)C(N/N=C/C=3C=C(C(=CC3)O)O)=O)O
 xref: CAS:304448-55-3;   PMID:18413242;   PMID:23596510;   PMID:24367704;   PMID:25421092;   PMID:25550455;   PMID:25850711;   PMID:25878109;   PMID:25889964;   PMID:26063501;   PMID:26894834;   Reaxys:20640593;   Reaxys:25249841

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  CHEBI ontology 19887
    chemical entity 19885
      atom 19885
        nonmetal atom 19809
          nitrogen atom 18982
            nitrogen molecular entity 18982
              hydrazide 1144
                dynasore 0
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  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            organic molecule 19713
                              organic cyclic compound 19505
                                carbocyclic compound 18602
                                  carbopolycyclic compound 17185
                                    carbobicyclic compound 5889
                                      naphthalenes 3853
                                        hydroxynaphthalene 280
                                          naphthols 250
                                            dynasore 0
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