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General

Strain: F344-Asip^ATyr^CKit^H/Kyo

Symbol:

F344-Asip^ATyr^CKit^H/Kyo

Strain:

F344-Asip^ATyr^CKit^H

Substrain:

Kyo

RGD ID:

11040974

Citation ID:

RRID:RGD_11040974

Ontology ID:

RS:0004158

Alleles:

Asip; Tyr; Kit

Also Known As:

Agouti Fischer; NBRP Rat No: 0769; F344-AsipATyrCKitH/Kyo; F344-Asip^[A]Tyr^[C]Kit^[H]/Kyo

Type:

mutant

Available Source:

National BioResource Project for the Rat in Japan

Origination:

National BioResource Project for the Rat in Japan

Description:

1) point mutation in the exon 2 of Tyrosinase (Tyr) gene (albino phenotype), 2) 19-bp deletion in Asip gene (Agouti phenotype), and 3) retrotransposon insertion (7-bp) in kit gene (hooded phenotype) were targeted by CRISPR/Cas9 system using ssODN. The rat coat colour phenotype was changed from white to Agouti. Background strain: F344/Stm

Last Known Status:

Live Animals; Cryopreserved Sperm

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	3	163,933,768 - 164,021,377	RGD_MAPPER_PIPELINE
GRCr8	14	32,901,615 - 32,978,895	RGD_MAPPER_PIPELINE
GRCr8	1	150,527,687 - 150,622,857	RGD_MAPPER_PIPELINE
mRatBN7.2	3	143,473,584 - 143,561,170	RGD_MAPPER_PIPELINE	mRatBN7.2
mRatBN7.2	1	141,115,036 - 141,210,207	RGD_MAPPER_PIPELINE	mRatBN7.2
mRatBN7.2	14	32,547,459 - 32,624,694	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	3	150,492,010 - 150,579,870	RGD_MAPPER_PIPELINE	Rnor_6.0
Rnor_6.0	1	151,012,598 - 151,106,802	RGD_MAPPER_PIPELINE	Rnor_6.0
Rnor_6.0	14	35,072,131 - 35,149,638	RGD_MAPPER_PIPELINE	Rnor_6.0
Rnor_5.0	14	34,901,860 - 34,979,384	RGD_MAPPER_PIPELINE	Rnor_5.0
Rnor_5.0	1	157,322,968 - 157,416,594	RGD_MAPPER_PIPELINE	Rnor_5.0
Rnor_5.0	3	156,860,395 - 156,949,277	RGD_MAPPER_PIPELINE	Rnor_5.0
RGSC_v3.4	1	143,641,257 - 143,746,315	RGD_MAPPER_PIPELINE	RGSC_v3.4
RGSC_v3.4	14	34,906,043 - 34,984,819	RGD_MAPPER_PIPELINE	RGSC_v3.4
RGSC_v3.4	3	145,445,175 - 145,536,831	RGD_MAPPER_PIPELINE	RGSC_v3.4

Annotation Click to see Annotation Detail View

References

References - curated

#	Reference Title	Reference Citation
1.	Strains registered by the National Bio Resource Project for the Rat in Japan	Personal Communication with NBRP
2.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
3.	Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform.	Yoshimi K, etal., Nat Commun. 2014 Jun 26;5:4240. doi: 10.1038/ncomms5240.

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_characteristics	Agouti coat colour (genetic background: F344/Stm)	1302502
strain_reproduction	homozygous condition (wild-type color: Agouti)	1302502

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: F344-AsipATyrCKitH/Kyo

Strain: F344-Asip^ATyr^CKit^H/Kyo