Flcn (folliculin) - Rat Genome Database

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Gene: Flcn (folliculin) Rattus norvegicus
Analyze
Symbol: Flcn
Name: folliculin
RGD ID: 735088
Description: Predicted to enable enzyme binding activity and enzyme inhibitor activity. Predicted to contribute to GTPase activator activity. Predicted to be involved in several processes, including negative regulation of brown fat cell differentiation; negative regulation of metabolic process; and regulation of intracellular signal transduction. Predicted to act upstream of or within with a positive effect on negative regulation of cell population proliferation. Predicted to act upstream of or within several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TORC1 signaling; and protein destabilization. Predicted to be located in several cellular components, including cilium; lysosomal membrane; and microtubule cytoskeleton. Predicted to be part of FNIP-folliculin RagC/D GAP. Predicted to be active in cytosol. Predicted to colocalize with cell-cell contact zone and midbody. Used to study renal cell carcinoma. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin); PARTICIPATES IN mTOR signaling pathway; renal cell carcinoma pathway; INTERACTS WITH 1-benzylpiperazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Bhd; Birt-Hogg-Dube syndrome protein homolog; MGC94558
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   BHD/Dspe
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,088,164 - 45,107,581 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1045,088,167 - 45,107,309 (-)EnsemblGRCr8
mRatBN7.21044,588,621 - 44,607,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,588,624 - 44,607,769 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1049,289,172 - 49,308,120 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,779,533 - 48,798,481 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01044,283,137 - 44,302,086 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01046,153,185 - 46,172,331 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,153,188 - 46,172,309 (-)Ensemblrn6Rnor6.0
Rnor_5.01045,909,609 - 45,928,715 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41046,110,527 - 46,129,613 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1043,850,423 - 43,869,275 (-)NCBICelera
RGSC_v3.11046,124,152 - 46,143,236 (-)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
amiodarone  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boron nitride  (ISO)
bortezomib  (ISO)
buspirone  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
leflunomide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
Octicizer  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorone  (EXP)
pinostrobin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
quercetin  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tributyl phosphate  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
biological_process  (ND)
cell-cell junction assembly  (IEA,ISO,ISS)
cellular response to amino acid starvation  (IEA,ISO,ISS)
cellular response to starvation  (IEA,ISO,ISS)
energy homeostasis  (IEA,ISO,ISS)
hemopoiesis  (ISO,ISS)
in utero embryonic development  (ISO,ISS)
intracellular signal transduction  (IEA,ISO,ISS)
lysosome localization  (IEA,ISO,ISS)
negative regulation of brown fat cell differentiation  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell proliferation involved in kidney development  (ISO,ISS)
negative regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO,ISS)
negative regulation of glycolytic process  (IEA,ISO)
negative regulation of intracellular signal transduction  (IEA)
negative regulation of lysosome organization  (IEA,ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
negative regulation of post-translational protein modification  (IEA,ISO)
negative regulation of Rho protein signal transduction  (IEA,ISO,ISS)
negative regulation of TOR signaling  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IBA,IEA,ISO,ISS)
positive regulation of apoptotic process  (ISS)
positive regulation of autophagy  (IEA,ISO,ISS)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of TOR signaling  (IEA,ISO,ISS)
positive regulation of TORC1 signaling  (IBA,IEA,ISO,ISS)
positive regulation of transforming growth factor beta receptor signaling pathway  (IBA,ISO,ISS)
regulation of pro-B cell differentiation  (ISO,ISS)
regulation of Ras protein signal transduction  (IEA,ISO,ISS)
regulation of TOR signaling  (ISO,ISS)

Cellular Component
cell-cell contact zone  (IEA,ISO,ISS)
centrosome  (IEA,ISO,ISS)
cilium  (IEA,ISO,ISS)
cytoplasm  (IEA,ISO,ISS)
cytosol  (IBA,IEA,ISO,ISS)
FNIP-folliculin RagC/D GAP  (IEA,ISO,ISS)
lysosomal membrane  (IEA,ISO,ISS)
midbody  (IEA,ISO,ISS)
mitotic spindle  (IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)
plasma membrane  (ISS)
spindle  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot. Goberdhan DC, etal., Cell Metab. 2016 Apr 12;23(4):580-9. doi: 10.1016/j.cmet.2016.03.013.
3. Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dube syndrome. Nickerson ML, etal., Cancer Cell. 2002 Aug;2(2):157-64.
4. A germ-line insertion in the Birt-Hogg-Dube (BHD) gene gives rise to the Nihon rat model of inherited renal cancer. Okimoto K, etal., Proc Natl Acad Sci U S A 2004 Feb 17;101(7):2023-7. Epub 2004 Feb 09.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene. Togashi Y, etal., Oncogene. 2006 May 11;25(20):2885-9. doi: 10.1038/sj.onc.1209317.
12. Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dube gene product. Wang L, etal., FEBS Lett. 2010 Jan 4;584(1):39-43. doi: 10.1016/j.febslet.2009.11.033. Epub .
13. Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1a/ERRa. Yan M, etal., Genes Dev. 2016 May 1;30(9):1034-46. doi: 10.1101/gad.281410.116.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16447066   PMID:17028174   PMID:18182616   PMID:18663353   PMID:18974783   PMID:19234517   PMID:19695222   PMID:19843504   PMID:19850877   PMID:20573232  
PMID:21209915   PMID:21258407   PMID:22709692   PMID:22965878   PMID:23150719   PMID:23784378   PMID:24081491   PMID:24095279   PMID:25126726   PMID:25775561   PMID:27113757   PMID:27913603  
PMID:29848618   PMID:31672913   PMID:31704029  


Genomics

Comparative Map Data
Flcn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,088,164 - 45,107,581 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1045,088,167 - 45,107,309 (-)EnsemblGRCr8
mRatBN7.21044,588,621 - 44,607,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,588,624 - 44,607,769 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1049,289,172 - 49,308,120 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,779,533 - 48,798,481 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01044,283,137 - 44,302,086 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01046,153,185 - 46,172,331 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,153,188 - 46,172,309 (-)Ensemblrn6Rnor6.0
Rnor_5.01045,909,609 - 45,928,715 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41046,110,527 - 46,129,613 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1043,850,423 - 43,869,275 (-)NCBICelera
RGSC_v3.11046,124,152 - 46,143,236 (-)NCBI
Cytogenetic Map10q22NCBI
FLCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381717,212,212 - 17,237,330 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1717,212,206 - 17,237,203 (-)Ensemblhg38GRCh38
GRCh371717,115,526 - 17,140,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,056,251 - 17,081,221 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1718,055,113 - 18,080,089 (-)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1716,868,444 - 16,893,256 (-)NCBIHuRef
CHM1_11717,125,252 - 17,150,222 (-)NCBICHM1_1
T2T-CHM13v2.01717,158,255 - 17,183,608 (-)NCBIT2T-CHM13v2.0
Flcn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,682,234 - 59,706,138 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,682,234 - 59,700,842 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381159,791,408 - 59,810,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,791,408 - 59,810,016 (-)Ensemblmm10GRCm38
MGSCv371159,605,252 - 59,623,275 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361159,607,945 - 59,625,968 (-)NCBIMGSCv36mm8
MGSCv361160,328,330 - 60,346,353 (-)NCBIMGSCv36mm8
Cytogenetic Map11B1.3NCBI
cM Map1137.79NCBI
Flcn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955577672,410 - 694,140 (+)Ensembl
ChiLan1.0NW_004955577672,774 - 694,140 (+)NCBIChiLan1.0ChiLan1.0
FLCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21951,729,626 - 51,754,802 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11756,441,317 - 56,466,479 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01734,057,127 - 34,081,637 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11738,988,520 - 39,013,189 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1738,988,518 - 39,013,160 (+)EnsemblpanPan2panpan1.1
FLCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1542,176,093 - 42,195,718 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl542,176,291 - 42,195,711 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha542,316,328 - 42,335,442 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0542,284,487 - 42,304,049 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl542,284,690 - 42,304,044 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1542,251,943 - 42,271,053 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0542,199,268 - 42,218,373 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0542,391,398 - 42,410,513 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Flcn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,965,873 - 61,986,098 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936741880,736 - 901,468 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936741881,150 - 901,296 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,031,157 - 61,045,392 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11261,029,186 - 61,045,400 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FLCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11616,245,840 - 16,271,465 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1616,245,715 - 16,267,698 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660594,642,225 - 4,670,076 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flcn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248494,157,683 - 4,179,724 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Flcn
107 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:276
Count of miRNA genes:186
Interacting mature miRNAs:227
Transcripts:ENSRNOT00000004412
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
11528628Bss116Bone structure and strength QTL 1166.464e-07femur morphology trait (VT:0000559)femur length (CMO:0000442)104467931246132467Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
PMC357045P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,590,918 - 44,591,095 (+)MAPPERmRatBN7.2
Rnor_6.01046,155,482 - 46,155,658NCBIRnor6.0
Rnor_5.01045,911,905 - 45,912,081UniSTSRnor5.0
RGSC_v3.41046,112,824 - 46,113,000UniSTSRGSC3.4
Celera1043,852,773 - 43,852,949UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,597,626 - 44,597,890 (+)MAPPERmRatBN7.2
Rnor_6.01046,162,190 - 46,162,453NCBIRnor6.0
Rnor_5.01045,918,578 - 45,918,841UniSTSRnor5.0
RGSC_v3.41046,119,494 - 46,119,757UniSTSRGSC3.4
Celera1043,859,156 - 43,859,419UniSTS
Cytogenetic Map10q22UniSTS
RH130087  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,588,656 - 44,588,840 (+)MAPPERmRatBN7.2
Rnor_6.01046,153,221 - 46,153,404NCBIRnor6.0
Rnor_5.01045,909,645 - 45,909,828UniSTSRnor5.0
RGSC_v3.41046,110,563 - 46,110,746UniSTSRGSC3.4
Celera1043,850,459 - 43,850,642UniSTS
RH 3.4 Map10499.3UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,591,953 - 44,592,131 (+)MAPPERmRatBN7.2
Rnor_6.01046,156,517 - 46,156,694NCBIRnor6.0
Rnor_5.01045,912,940 - 45,913,117UniSTSRnor5.0
RGSC_v3.41046,113,859 - 46,114,036UniSTSRGSC3.4
Celera1043,853,796 - 43,853,973UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,590,841 - 44,591,222 (+)MAPPERmRatBN7.2
Rnor_6.01046,155,405 - 46,155,785NCBIRnor6.0
Rnor_5.01045,911,828 - 45,912,208UniSTSRnor5.0
RGSC_v3.41046,112,747 - 46,113,127UniSTSRGSC3.4
Celera1043,852,696 - 43,853,076UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,589,395 - 44,589,664 (+)MAPPERmRatBN7.2
Rnor_6.01046,153,960 - 46,154,228NCBIRnor6.0
Rnor_5.01045,910,384 - 45,910,652UniSTSRnor5.0
RGSC_v3.41046,111,302 - 46,111,570UniSTSRGSC3.4
Celera1043,851,198 - 43,851,466UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,600,366 - 44,601,103 (+)MAPPERmRatBN7.2
Rnor_6.01046,164,930 - 46,165,666NCBIRnor6.0
Rnor_5.01045,921,318 - 45,922,054UniSTSRnor5.0
RGSC_v3.41046,122,234 - 46,122,970UniSTSRGSC3.4
Celera1043,861,896 - 43,862,632UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,601,043 - 44,601,372 (+)MAPPERmRatBN7.2
Rnor_6.01046,165,607 - 46,165,935NCBIRnor6.0
Rnor_5.01045,921,995 - 45,922,323UniSTSRnor5.0
RGSC_v3.41046,122,911 - 46,123,239UniSTSRGSC3.4
Celera1043,862,573 - 43,862,901UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,600,233 - 44,600,465 (+)MAPPERmRatBN7.2
Rnor_6.01046,164,797 - 46,165,028NCBIRnor6.0
Rnor_5.01045,921,185 - 45,921,416UniSTSRnor5.0
RGSC_v3.41046,122,101 - 46,122,332UniSTSRGSC3.4
Celera1043,861,763 - 43,861,994UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,598,612 - 44,598,911 (+)MAPPERmRatBN7.2
Rnor_6.01046,163,176 - 46,163,474NCBIRnor6.0
Rnor_5.01045,919,564 - 45,919,862UniSTSRnor5.0
RGSC_v3.41046,120,480 - 46,120,778UniSTSRGSC3.4
Celera1043,860,142 - 43,860,440UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,596,237 - 44,596,458 (+)MAPPERmRatBN7.2
Rnor_6.01046,160,801 - 46,161,021NCBIRnor6.0
Rnor_5.01045,917,189 - 45,917,409UniSTSRnor5.0
RGSC_v3.41046,118,105 - 46,118,325UniSTSRGSC3.4
Celera1043,857,767 - 43,857,987UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,595,303 - 44,595,562 (+)MAPPERmRatBN7.2
Rnor_6.01046,159,867 - 46,160,125NCBIRnor6.0
Rnor_5.01045,916,255 - 45,916,513UniSTSRnor5.0
RGSC_v3.41046,117,171 - 46,117,429UniSTSRGSC3.4
Celera1043,856,833 - 43,857,091UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,592,599 - 44,592,774 (+)MAPPERmRatBN7.2
Rnor_6.01046,157,163 - 46,157,337NCBIRnor6.0
Rnor_5.01045,913,586 - 45,913,760UniSTSRnor5.0
RGSC_v3.41046,114,505 - 46,114,679UniSTSRGSC3.4
Celera1043,854,442 - 43,854,616UniSTS
Cytogenetic Map10q22UniSTS


Related Rat Strains
The following Strains have been annotated to Flcn
BHD/Dspe    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_199390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB096213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC097038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000004412   ⟹   ENSRNOP00000004412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1045,088,167 - 45,107,309 (-)Ensembl
mRatBN7.2 Ensembl1044,588,624 - 44,607,769 (-)Ensembl
Rnor_6.0 Ensembl1046,153,188 - 46,172,309 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091052   ⟹   ENSRNOP00000075720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1046,154,745 - 46,172,166 (-)Ensembl
RefSeq Acc Id: NM_199390   ⟹   NP_955422
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,088,164 - 45,107,289 (-)NCBI
mRatBN7.21044,588,621 - 44,607,749 (-)NCBI
Rnor_6.01046,153,185 - 46,172,309 (-)NCBI
Rnor_5.01045,909,609 - 45,928,715 (-)NCBI
RGSC_v3.41046,110,527 - 46,129,613 (-)RGD
Celera1043,850,423 - 43,869,275 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246489   ⟹   XP_006246551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,088,164 - 45,107,345 (-)NCBI
mRatBN7.21044,588,879 - 44,607,807 (-)NCBI
Rnor_6.01046,153,967 - 46,172,154 (-)NCBI
Rnor_5.01045,909,609 - 45,928,715 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246490   ⟹   XP_006246552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,088,164 - 45,107,581 (-)NCBI
mRatBN7.21044,588,621 - 44,607,769 (-)NCBI
Rnor_6.01046,153,185 - 46,172,329 (-)NCBI
Rnor_5.01045,909,609 - 45,928,715 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597267   ⟹   XP_017452756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,088,164 - 45,107,254 (-)NCBI
mRatBN7.21044,588,621 - 44,607,807 (-)NCBI
Rnor_6.01046,153,185 - 46,171,022 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597270   ⟹   XP_017452759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,088,164 - 45,107,314 (-)NCBI
mRatBN7.21044,588,621 - 44,607,808 (-)NCBI
Rnor_6.01046,153,185 - 46,172,331 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085951   ⟹   XP_038941879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,088,164 - 45,107,338 (-)NCBI
mRatBN7.21044,588,621 - 44,607,807 (-)NCBI
RefSeq Acc Id: XM_039085952   ⟹   XP_038941880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,088,164 - 45,107,254 (-)NCBI
mRatBN7.21044,588,621 - 44,607,807 (-)NCBI
RefSeq Acc Id: XM_063268998   ⟹   XP_063125068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,088,164 - 45,106,998 (-)NCBI
RefSeq Acc Id: XM_063268999   ⟹   XP_063125069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,088,164 - 45,107,254 (-)NCBI
RefSeq Acc Id: XM_063269000   ⟹   XP_063125070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,088,164 - 45,107,254 (-)NCBI
RefSeq Acc Id: XM_063269001   ⟹   XP_063125071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,088,164 - 45,107,309 (-)NCBI
RefSeq Acc Id: XM_063269002   ⟹   XP_063125072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,088,164 - 45,107,309 (-)NCBI
RefSeq Acc Id: XM_063269003   ⟹   XP_063125073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81045,088,164 - 45,107,317 (-)NCBI
RefSeq Acc Id: NP_955422   ⟸   NM_199390
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006246552   ⟸   XM_006246490
- Peptide Label: isoform X1
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006246551   ⟸   XM_006246489
- Peptide Label: isoform X1
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017452759   ⟸   XM_017597270
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017452756   ⟸   XM_017597267
- Peptide Label: isoform X1
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004412   ⟸   ENSRNOT00000004412
Ensembl Acc Id: ENSRNOP00000075720   ⟸   ENSRNOT00000091052
RefSeq Acc Id: XP_038941880   ⟸   XM_039085952
- Peptide Label: isoform X1
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038941879   ⟸   XM_039085951
- Peptide Label: isoform X1
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063125073   ⟸   XM_063269003
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063125072   ⟸   XM_063269002
- Peptide Label: isoform X1
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063125071   ⟸   XM_063269001
- Peptide Label: isoform X1
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063125069   ⟸   XM_063268999
- Peptide Label: isoform X1
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063125070   ⟸   XM_063269000
- Peptide Label: isoform X1
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063125068   ⟸   XM_063268998
- Peptide Label: isoform X1
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
Protein Domains
cDENN FLCN/SMCR8-type   dDENN FLCN/SMCR8-type   uDENN FLCN/SMCR8-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q76JQ2-F1-model_v2 AlphaFold Q76JQ2 1-579 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697243
Promoter ID:EPDNEW_R7764
Type:initiation region
Name:Flcn_1
Description:folliculin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01046,172,116 - 46,172,176EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735088 AgrOrtholog
BioCyc Gene G2FUF-24874 BioCyc
Ensembl Genes ENSRNOG00000003302 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004412 ENTREZGENE
  ENSRNOT00000004412.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.1730 UniProtKB/Swiss-Prot
  3.40.50.12430 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7189414 IMAGE-MGC_LOAD
InterPro FLCN/SMCR8_DENN UniProtKB/Swiss-Prot
  FLCN_DENN_C_sf UniProtKB/Swiss-Prot
  Folliculin UniProtKB/Swiss-Prot
  Folliculin/SMCR8_N UniProtKB/Swiss-Prot
  Folliculin_C UniProtKB/Swiss-Prot
KEGG Report rno:303185 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94558 IMAGE-MGC_LOAD
NCBI Gene 303185 ENTREZGENE
PANTHER FOLLICULIN UniProtKB/Swiss-Prot
  PTHR31441 UniProtKB/Swiss-Prot
Pfam Folliculin UniProtKB/Swiss-Prot
  Folliculin_C UniProtKB/Swiss-Prot
PhenoGen Flcn PhenoGen
PROSITE DENN_FLCN_SMCR8 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003302 RatGTEx
UniProt A6HF16_RAT UniProtKB/TrEMBL
  FLCN_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Flcn  folliculin  Bhd    Symbol updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease in heterozygotes, a germline insertion of one nucleotide resulting in a nonsense mutation gives rise to renal adenocarcinomas by the age of 6 months; homozygosity is lethal at an early stage of embryogenesis 1302869
gene_homology amino acid sequence is 93% and 97% homologous to human and mouse folliculin, respectively 1302869
gene_mutations_overexpression 10 of 11 renal carcinomas showed a loss of heterozygosity at the Bhd locus and the one LOH-negative case displayed a spontaneous nonsense point mutation at the second Bhd locus 1302869