Flcn (folliculin) - Rat Genome Database

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Pathways
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Gene: Flcn (folliculin) Chinchilla lanigera
Analyze
Symbol: Flcn
Name: folliculin
RGD ID: 8757659
Description: ENCODES a protein that exhibits enzyme binding (ortholog); enzyme inhibitor activity (ortholog); GTPase activator activity (ortholog); INVOLVED IN cell proliferation involved in kidney development (ortholog); cell-cell junction assembly (ortholog); cellular response to amino acid starvation (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Birt-Hogg-Dube syndrome (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN cell-cell contact zone (ortholog); centrosome (ortholog); cilium (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955577672,410 - 694,140 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955577672,774 - 694,140 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell proliferation involved in kidney development  (ISO)
cell-cell junction assembly  (ISO)
cellular response to amino acid starvation  (ISO)
cellular response to starvation  (ISO)
energy homeostasis  (ISO)
epithelial cell proliferation  (ISO)
ERK1 and ERK2 cascade  (ISO)
hemopoiesis  (ISO)
in utero embryonic development  (ISO)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway  (ISO)
lysosome localization  (ISO)
negative regulation of brown fat cell differentiation  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell proliferation involved in kidney development  (ISO)
negative regulation of cold-induced thermogenesis  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of glycolytic process  (ISO)
negative regulation of lysosome organization  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of post-translational protein modification  (ISO)
negative regulation of Rho protein signal transduction  (ISO)
negative regulation of TOR signaling  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of TOR signaling  (ISO)
positive regulation of TORC1 signaling  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulation of pro-B cell differentiation  (ISO)
regulation of Ras protein signal transduction  (ISO)
regulation of TOR signaling  (ISO)
TOR signaling  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Flcn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955577672,410 - 694,140 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955577672,774 - 694,140 (+)NCBIChiLan1.0ChiLan1.0
FLCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381717,212,212 - 17,237,330 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1717,212,212 - 17,237,188 (-)EnsemblGRCh38hg38GRCh38
GRCh371717,115,526 - 17,140,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,056,251 - 17,081,221 (-)NCBINCBI36Build 36hg18NCBI36
Celera1718,055,113 - 18,080,089 (-)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1716,868,444 - 16,893,256 (-)NCBIHuRef
CHM1_11717,125,252 - 17,150,222 (-)NCBICHM1_1
T2T-CHM13v2.01717,158,255 - 17,183,608 (-)NCBIT2T-CHM13v2.0
Flcn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,682,234 - 59,706,138 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,682,234 - 59,700,842 (-)EnsemblGRCm39 Ensembl
GRCm381159,791,408 - 59,810,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,791,408 - 59,810,016 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,605,252 - 59,623,275 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361159,607,945 - 59,625,968 (-)NCBIMGSCv36mm8
MGSCv361160,328,330 - 60,346,353 (-)NCBIMGSCv36mm8
Cytogenetic Map11B1.3NCBI
cM Map1137.79NCBI
Flcn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,088,164 - 45,107,581 (-)NCBIGRCr8
mRatBN7.21044,588,621 - 44,607,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,588,624 - 44,607,769 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,289,172 - 49,308,120 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,779,533 - 48,798,481 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01044,283,137 - 44,302,086 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01046,153,185 - 46,172,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,153,188 - 46,172,309 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,909,609 - 45,928,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,110,527 - 46,129,613 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11046,124,152 - 46,143,236 (-)NCBI
Celera1043,850,423 - 43,869,275 (-)NCBICelera
Cytogenetic Map10q22NCBI
FLCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21951,729,626 - 51,754,802 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11756,441,317 - 56,466,479 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01734,057,127 - 34,081,637 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11738,988,520 - 39,013,189 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1738,988,518 - 39,013,160 (+)Ensemblpanpan1.1panPan2
FLCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1542,176,093 - 42,195,718 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl542,176,291 - 42,195,711 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha542,316,328 - 42,335,442 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0542,284,487 - 42,304,049 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl542,284,690 - 42,304,044 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1542,251,943 - 42,271,053 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0542,199,268 - 42,218,373 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0542,391,398 - 42,410,513 (+)NCBIUU_Cfam_GSD_1.0
Flcn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,965,873 - 61,986,098 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936741880,736 - 901,468 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936741881,150 - 901,296 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,031,157 - 61,045,392 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,029,186 - 61,045,400 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FLCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11616,245,840 - 16,271,465 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1616,245,715 - 16,267,698 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660594,642,225 - 4,670,076 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flcn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248494,157,683 - 4,179,724 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000000211   ⟹   ENSCLAP00000000184
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955577672,410 - 694,140 (+)Ensembl
RefSeq Acc Id: XM_005413976   ⟹   XP_005414033
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955577672,776 - 694,140 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005413977   ⟹   XP_005414034
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955577672,774 - 694,140 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005413978   ⟹   XP_005414035
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955577675,814 - 694,140 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005414033 (Get FASTA)   NCBI Sequence Viewer  
  XP_005414034 (Get FASTA)   NCBI Sequence Viewer  
  XP_005414035 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000000184
  ENSCLAP00000000184.1
Reference Protein Sequences
RefSeq Acc Id: XP_005414033   ⟸   XM_005413976
- UniProtKB: A0A8C2UKE0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005414034   ⟸   XM_005413977
- UniProtKB: A0A8C2UKE0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005414035   ⟸   XM_005413978
- UniProtKB: A0A8C2UKE0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000000184   ⟸   ENSCLAT00000000211
Protein Domains
uDENN FLCN/SMCR8-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000000185 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000000211 ENTREZGENE
  ENSCLAT00000000211.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1730 UniProtKB/TrEMBL
  3.40.50.12430 UniProtKB/TrEMBL
InterPro FLCN/SMCR8_DENN UniProtKB/TrEMBL
  FLCN_DENN_C_sf UniProtKB/TrEMBL
  Folliculin UniProtKB/TrEMBL
  Folliculin/SMCR8_longin UniProtKB/TrEMBL
  Folliculin_DENN UniProtKB/TrEMBL
NCBI Gene Flcn ENTREZGENE
PANTHER FOLLICULIN UniProtKB/TrEMBL
  PTHR31441 UniProtKB/TrEMBL
Pfam Folliculin UniProtKB/TrEMBL
  Folliculin_C UniProtKB/TrEMBL
PROSITE DENN_FLCN_SMCR8 UniProtKB/TrEMBL
UniProt A0A8C2UKE0 ENTREZGENE, UniProtKB/TrEMBL