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Gene: Nme8 (NME/NM23 family member 8) Rattus norvegicus

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Symbol:

Nme8

Name:

NME/NM23 family member 8

RGD ID:

735069

Description:

Predicted to enable 3'-5'-DNA exonuclease activity and microtubule binding activity. Predicted to be involved in DNA catabolic process; cilium assembly; and flagellated sperm motility. Predicted to act upstream of or within cellular response to reactive oxygen species. Located in sperm fibrous sheath. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 6. Orthologous to human NME8 (NME/NM23 family member 8); INTERACTS WITH bisphenol A; trichloroethene; 17alpha-ethynylestradiol (ortholog).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

3'-5' exonuclease NME8; spermatid-specific thioredoxin-2 protein; sptrx-2; Sptrx2; thioredoxin domain containing 3; thioredoxin domain containing 3 (spermatozoa); thioredoxin domain-containing protein 3; Txndc3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NME8 (NME/NM23 family member 8)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther, PhylomeDB
Mus musculus (house mouse):	Nme8 (NME/NM23 family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nme8 (NME/NM23 family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NME8 (NME/NM23 family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NME8 (NME/NM23 family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nme8 (NME/NM23 family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NME8 (NME/NM23 family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NME8 (NME/NM23 family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nme8 (NME/NM23 family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Nme8 (NME/NM23 family member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NME8 (NME/NM23 family member 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nme8 (NME/NM23 family member 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nme8 (NME/NM23 family member 8)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	nme8 (NME/NM23 family member 8)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG18130	Alliance	DIOPT (InParanoid\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG14221	Alliance	DIOPT (InParanoid\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	nme9	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	49,932,861 - 50,000,610 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	49,932,860 - 50,000,608 (+)	Ensembl				GRCr8
mRatBN7.2	17	45,237,022 - 45,304,948 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	45,238,120 - 45,304,948 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	47,314,521 - 47,383,402 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	52,073,680 - 52,142,565 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	46,564,073 - 46,632,963 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	47,300,932 - 47,368,543 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	47,301,511 - 47,368,553 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	56,120,328 - 56,185,444 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	53,037,090 - 53,105,985 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	51,224,029 - 51,290,939 (-)	NCBI		Celera
RGSC_v3.1	17	53,040,678 - 53,108,823 (+)	NCBI
Cytogenetic Map	17	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

primary ciliary dyskinesia (ISO)

primary ciliary dyskinesia 6 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

antirheumatic drug (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

dorsomorphin (ISO)

entinostat (ISO)

genistein (ISO)

mercury dibromide (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

ozone (ISO)

panobinostat (ISO)

phenylmercury acetate (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

tamoxifen (ISO)

Tributyltin oxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

cellular response to reactive oxygen species (ISO)

cilium assembly (IBA,ISO)

DNA catabolic process (IEA,ISO,ISS)

flagellated sperm motility (IBA,ISO)

spermatid development (NAS)

spermatogenesis (IEA)

Cellular Component

axoneme (IBA,IEA,ISO)

cytoplasm (IEA,ISO)

cytosol (IEA,ISO)

nucleus (IEA,ISO)

outer dynein arm (IEA,ISO)

sperm cytoplasmic droplet (IEA,ISO)

sperm fibrous sheath (IDA)

sperm flagellum (IEA)

sperm midpiece (IEA,ISO)

sperm principal piece (IBA,IEA,ISO)

Molecular Function

3'-5'-DNA exonuclease activity (IEA,ISO,ISS)

hydrolase activity (IEA)

microtubule binding (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Cloning and developmental analysis of murid spermatid-specific thioredoxin-2 (SPTRX-2), a novel sperm fibrous sheath protein and autoantigen.	Miranda-Vizuete A, etal., J Biol Chem 2003 Nov 7;278(45):44874-85. Epub 2003 Aug 7.
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:17360648	PMID:22871113	PMID:23707457

Genomics

Comparative Map Data

Nme8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	49,932,861 - 50,000,610 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	49,932,860 - 50,000,608 (+)	Ensembl				GRCr8
mRatBN7.2	17	45,237,022 - 45,304,948 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	45,238,120 - 45,304,948 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	47,314,521 - 47,383,402 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	52,073,680 - 52,142,565 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	46,564,073 - 46,632,963 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	47,300,932 - 47,368,543 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	47,301,511 - 47,368,553 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	56,120,328 - 56,185,444 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	53,037,090 - 53,105,985 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	51,224,029 - 51,290,939 (-)	NCBI		Celera
RGSC_v3.1	17	53,040,678 - 53,108,823 (+)	NCBI
Cytogenetic Map	17	q11	NCBI

NME8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	37,848,597 - 37,900,397 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	37,848,597 - 37,900,397 (+)	Ensembl			hg38	GRCh38
GRCh37	7	37,888,199 - 37,939,999 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	37,854,724 - 37,906,528 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	37,661,438 - 37,713,238	NCBI
Celera	7	37,872,948 - 37,924,718 (+)	NCBI		Celera
Cytogenetic Map	7	p14.1	NCBI
HuRef	7	37,768,407 - 37,820,357 (+)	NCBI		HuRef
CHM1_1	7	37,887,675 - 37,939,959 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	37,989,652 - 38,041,414 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	37,926,134 - 37,977,903 (+)	NCBI

Nme8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	19,829,248 - 19,881,996 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	19,829,248 - 19,881,964 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	19,645,078 - 19,697,826 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	19,645,078 - 19,697,794 (-)	Ensembl			mm10	GRCm38
MGSCv37	13	19,736,947 - 19,789,629 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	19,652,543 - 19,705,225 (-)	NCBI		MGSCv36	mm8
Celera	13	19,988,291 - 19,996,418 (-)	NCBI		Celera
Cytogenetic Map	13	A2	NCBI
cM Map	13	7.0	NCBI

Nme8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955460	5,680,678 - 5,718,628 (-)	Ensembl
ChiLan1.0	NW_004955460	5,672,768 - 5,718,707 (-)	NCBI	ChiLan1.0	ChiLan1.0

NME8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	42,326,546 - 42,733,330 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	90,651,590 - 91,058,066 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	38,128,610 - 38,536,611 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	38,708,937 - 38,757,802 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	38,708,937 - 38,757,795 (+)	Ensembl			panPan2	panpan1.1

NME8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	12,038,369 - 12,088,544 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	12,038,450 - 12,087,626 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	11,682,915 - 11,733,063 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	12,309,712 - 12,359,547 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	12,309,802 - 12,358,644 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	12,126,922 - 12,176,754 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	12,047,339 - 12,097,182 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	12,274,833 - 12,324,653 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Nme8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	93,964,657 - 94,040,183 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936478	13,177,529 - 13,243,037 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936478	13,176,388 - 13,243,043 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NME8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	108,358,535 - 108,392,781 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	108,358,289 - 108,393,755 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	119,105,762 - 119,136,177 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NME8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	20,617,683 - 20,670,346 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	20,620,941 - 20,668,888 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666062	1,671,514 - 1,725,043 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nme8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	23,349,858 - 23,396,888 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624740	23,351,832 - 23,396,905 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Nme8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	38,387,841 - 38,450,617 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Nme8
434 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	166
Count of miRNA genes:	62
Interacting mature miRNAs:	67
Transcripts:	ENSRNOT00000059201, ENSRNOT00000059202, ENSRNOT00000066673
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631497	Bp98	Blood pressure QTL 98	3.66		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	49496932	65155015	Rat
70210	Cm15	Cardiac mass QTL 15	6.5		heart right ventricle mass (VT:0007033)	heart right ventricle wet weight (CMO:0000072)	17	30066472	75066472	Rat
8552966	Pigfal18	Plasma insulin-like growth factor 1 level QTL 18	8.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	12860942	57860942	Rat
152023626	Bp403	Blood pressure QTL 403	3.86		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	42388164	87388164	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	33104645	78104645	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	6221998	58177198	Rat
1354654	Spl7	Serum phospholipid level QTL 7	5.5		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	17	38031354	83031354	Rat
70157	Niddm32	Non-insulin dependent diabetes mellitus QTL 32	4.34		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	22660799	55604694	Rat
9589151	Insul30	Insulin level QTL 30	8.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	12860942	57860942	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40968017	89341781	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27233445	83975845	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21498994	50592236	Rat
1354629	Scl31	Serum cholesterol level QTL 31	4.1		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	17	38031354	83031354	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23286322	64246472	Rat
9589057	Scfw6	Subcutaneous fat weight QTL 6	8.62	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	17	12860942	57860942	Rat
1600398	Edcs5	Endometrial carcinoma susceptibility QTL 5	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	17	35446949	75762341	Rat
2317045	Aia11	Adjuvant induced arthritis QTL 11	4.06		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	26522051	71522051	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23858926	68858926	Rat
9590154	Scort9	Serum corticosterone level QTL 9	23.57	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	12860942	57860942	Rat
10450503	Bp386	Blood pressure QTL 386		0.28	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	22019705	67019705	Rat
152025238	Slep14	Serum leptin concentration QTL 14	4.62		blood leptin amount (VT:0005667)		17	24390595	84432719	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	38031354	83031354	Rat
9590088	Insglur7	Insulin/glucose ratio QTL 7	20.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	17	12860942	57860942	Rat
2313854	Bp343	Blood pressure QTL 343	3.9		life span trait (VT:0005372)	age at time of death (CMO:0001193)	17	32199534	55604694	Rat
2317053	Aia25	Adjuvant induced arthritis QTL 25	2.69		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	10604694	55604694	Rat
1354635	Bp245	Blood pressure QTL 245	6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	38031354	83031354	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15537025	60531414	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	33104645	78104645	Rat
7411666	Foco31	Food consumption QTL 31	11.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	17	12860942	57860942	Rat
12904736	Cm121	Cardiac mass QTL 121		0.043	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	42388164	87388164	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	46050126	91050126	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23858926	68858926	Rat
4889891	Eae32	Experimental allergic encephalomyelitis QTL 32	4.8	0.0002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	27233445	72233445	Rat
4889955	Bss93	Bone structure and strength QTL 93	4.4		tibia size trait (VT:0100001)	tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)	17	27233445	65155015	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23858926	68858926	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23858926	68858926	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	42654895	87654895	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23858926	68858926	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	37687877	82687877	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23858926	68858926	Rat
1300129	Rf25	Renal function QTL 25	3.03		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	17	41062352	86062352	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	32199534	86201342	Rat
152023740	Bp406	Blood pressure QTL 406	6.06		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23858926	68858926	Rat
152023737	Bp405	Blood pressure QTL 405	5.06		arterial blood pressure trait (VT:2000000)			24136127	84432719	Rat
152023736	Bp404	Blood pressure QTL 404	3.78		arterial blood pressure trait (VT:2000000)		17	24136127	84432719	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	36045537	81045537	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
8	10	14	69	54	55	25	81	25	6	182	122	11	42	19	54	30	3	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_198792	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017600637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276669	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276670	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276671	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005495310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010058906	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC123245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF548544	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000087178 ⟹ ENSRNOP00000074097

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	45,238,126 - 45,304,946 (+)	Ensembl
Rnor_6.0 Ensembl	17	47,301,518 - 47,368,541 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000090021 ⟹ ENSRNOP00000068777

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	49,932,860 - 50,000,608 (+)	Ensembl
mRatBN7.2 Ensembl	17	45,238,120 - 45,304,948 (+)	Ensembl
Rnor_6.0 Ensembl	17	47,302,272 - 47,364,209 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092051 ⟹ ENSRNOP00000069890

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	49,933,762 - 50,000,608 (+)	Ensembl
mRatBN7.2 Ensembl	17	45,238,120 - 45,304,948 (+)	Ensembl
Rnor_6.0 Ensembl	17	47,301,511 - 47,368,553 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095832 ⟹ ENSRNOP00000096759

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	45,238,120 - 45,255,889 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113182 ⟹ ENSRNOP00000091968

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	45,238,120 - 45,304,808 (+)	Ensembl

RefSeq Acc Id:

NM_198792 ⟹ NP_942087

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	49,933,753 - 50,000,610 (+)	NCBI
mRatBN7.2	17	45,238,087 - 45,304,948 (+)	NCBI
Rnor_6.0	17	47,301,512 - 47,368,543 (+)	NCBI
Rnor_5.0	17	56,120,328 - 56,185,444 (-)	NCBI
RGSC_v3.4	17	53,037,090 - 53,105,985 (+)	RGD
Celera	17	51,224,029 - 51,290,939 (-)	RGD

Sequence:

show sequence

GGTGATGCCAGGCATCCCTCATCCCCTCCTTTAACTGGACCTGCTGGGGAAGAAGGCACAGCAG
GAACCCTGCCACCTTTAGCCTGAGCCTGACCCAGAACTGGTCCAGCAGACAAATGGCAAGCAAA
AAACGTGAAGTCCAGCTACAGTCAGTCGTCAATAGTCAGAACTTGTGGGATGAGATGTTGCTGA
ACAAAGGCTTAACAGTGATTGATGTATACCAAGCCTGGTGTGGACCCTGCAAAGCCGTGCAAGC
TTTATTCAGAAAACTAAAAAATGAACTGAATGAAGATGAGCTTCTTCATTTTGTCGTTGCGGAA
GCTGACAGCATTGTGACTCTGCAGCCATTTAGAGATAAATGTGAGCCTGTGTTCCTCTTCAGTC
TTAATGGTAAAATTATTGCAAAGATTCAGGGTGCAAATGCACCACTTATCAATAGAAAAGTCAT
TGCATTGATAGATGAAGAGAAGAAAATTGCAGCAGGTGAAATGGCTCGTCCTCAGTATGTTGAA
ATTCCACTAGTAGACTCATTGGACGAAGAATATGGGGAAGTGCACTATGAAAGTAATGTGGAAG
TTTACAATATGGCAGTTATCAACCCTGATGCTGTACTCATGAGAAAAAATTTGGAAATTAAGGA
AAAAATAACCAAAGAAGGATTTATCATAGAAATACAGGAAAACATGCTTCTCCCCGAAGAGGTA
GCGAGGGAATTCTACAATCATATGATAGATGAGCCTGACTTTGAAGAGTTTGTATATTCTATGA
CAAACCGCCTAAGCTGTGTGCTCATTATATCTCAAGGAGAAGACACAGAGGTTATTGAGGAGGA
AGCTCTCCCTCAGTCTGATGATGAAGAAGAAGAAGAAGAAGAAGAAGTAGTAGAAGAACCTGAC
CCTTTGGAAGAGCCTCACGTTAGGTTTGCACCTATGCTGGTAAAGAAGAAACGGGACAGTTTGC
AAGAGTATATGGACCGACAACATATGTCTGATTACTGTCATGTCGAGGATGATGCGGTTAAGGT
GTCCAAGTTCATTGACATATTATTCCCTGATTTTAAAACCATGAAAAGCACGAATGTACAAAGG
ACACTAGGATTACTGTATCCAGAAGTCTGTGAGGAAGAGAAAGATAATGTGTTGGACATTATTC
AAAATGAAGGGTTCACTATATTGATGCAGAGGCAAGTCGTATTATCAGAGGAAGAGGCAAGAGC
AGTGTGCCACGTCCATGAGGATGAAGACTATTTTGATAATCTTATAGGATACATGTGCAGTAAT
AACTCTTATATCCTTGTTCTAATGAGGGAACATAGTGTGGAACGTTGGAAAGAGTTAATCGGGC
CTAAAACTGTTGAGGAGGCTTATGCATCTCATCCAGACAGTTTATGTGTACGGTTTGCTTCAGG
AAATTTTCCTGTCAACCAGTTCTATGGGAGCAGTTCAAAAGCAGCAGCTGAGACAGAAATAGAG
CATTTCTTTCCTCCTCAGAGTACGCTGGCATTGATTAAGCCTCACGTGTCACACAAAGAAAGAA
TGGAGATTCTGAAGGCCATTAGAGATGCAAGATTTGAGCTGACCCAGATGAAAGAAATGCACCT
GACTCCGGAGCATGCAAGCAAAGTTTATTTCAAAATAACAGGAAAAGATTTCTATAAAAATGTA
TTGGACGTCTTATCTTCGGGCATGTCAGTAGTCATGATTCTGACCAAGTGGAATGCTGTTGGAG
AATGGAGGCGAATGATGGGCCCAGTAGACCCAGAAGAAGCAAAACTGCTGTCTCCAAATTCCCT
CCGAGCCAGATATGGAATAGACGTTTTGAGAAATGCTGTCCATGGGGCATCTAACATGTCTGAA
GCAGCAACTGCCATTAGTAATGTGTTCACAGAGAGCAATTTTGAGAACTAGGACAAATACTAGA
TTCATAGAAACTCAATGAGATAATGAAGAAGTTTCATCACATAAAACCATGAGGCACAACTTCC
TGTAAAGAGTAAGAACAAAAATTTCTCCAAGAGAAACACACATGGAGATGAAAACTCGCATGGC
TATGCATGGTAACAATAAAAACTGTAACCCCCCAA

hide sequence

RefSeq Acc Id:

XM_017600636 ⟹ XP_017456125

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	49,932,861 - 50,000,610 (+)	NCBI
mRatBN7.2	17	45,237,422 - 45,304,948 (+)	NCBI
Rnor_6.0	17	47,300,932 - 47,368,543 (+)	NCBI

Sequence:

show sequence

GTGGGAATCCGAATATCATTTTGGCAGAACTTTTGTAACTCTAAACATTTAAATAGTTAAAATG
GCAGTGCTATGGGTCCAGTGCCTAGGTGGGAACGGAGGAAGGAGACCATGAGGATGAGACCATC
AGAGAACAATAGCGAAGGTGGAGAGTCAGCTCAGCAGGAAGGAAGGCCTGTTTTTGCTTCAATT
TGAGGGATTTGTACGCATATTGTAAGGCTTGGCTGATCCCCTAGGATTCAAAGCCTAGGAGAGA
GACTTCCAGCAGACAAATGGCAAGCAAAAAACGTGAAGTCCAGCTACAGTCAGTCGTCAATAGT
CAGAACTTGTGGGATGAGATGTTGCTGAACAAAGGCTTAACAGTGATTGATGTATACCAAGCCT
GGTGTGGACCCTGCAAAGCCGTGCAAGCTTTATTCAGAAAACTAAAAAATGAACTGAATGAAGA
TGAGCTTCTTCATTTTGTCGTTGCGGAAGCTGACAGCATTGTGACTCTGCAGCCATTTAGAGAT
AAATGTGAGCCTGTGTTCCTCTTCAGTCTTAATGGTAAAATTATTGCAAAGATTCAGGGTGCAA
ATGCACCACTTATCAATAGAAAAGTCATTGCATTGATAGATGAAGAGAAGAAAATTGCAGCAGG
TGAAATGGCTCGTCCTCAGTATGTTGAAATTCCACTAGTAGACTCATTGGACGAAGAATATGGG
GAAGTGCACTATGAAAGTAATGTGGAAGTTTACAATATGGCAGTTATCAACCCTGATGCTGTAC
TCATGAGAAAAAATTTGGAAATTAAGGAAAAAATAACCAAAGAAGGATTTATCATAGAAATACA
GGAAAACATGCTTCTCCCCGAAGAGGTAGCGAGGGAATTCTACAATCATATGATAGATGAGCCT
GACTTTGAAGAGTTTGTATATTCTATGACAAACCGCCTAAGCTGTGTGCTCATTATATCTCAAG
GAGAAGACACAGAGGTTATTGAGGAGGAAGCTCTCCCTCAGTCTGATGATGAAGAAGAAGAAGA
AGAAGAAGAAGTAGTAGAAGAACCTGACCCTTTGGAAGAGCCTCACGTTAGGTTTGCACCTATG
CTGGTAAAGAAGAAACGGGACAGTTTGCAAGAGTATATGGACCGACAACATATGTCTGATTACT
GTCATGTCGAGGATGATGCGGTTAAGGTGTCCAAGTTCATTGACATATTATTCCCTGATTTTAA
AACCATGAAAAGCACGAATGTACAAAGGACACTAGGATTACTGTATCCAGAAGTCTGTGAGGAA
GAGAAAGATAATGTGTTGGACATTATTCAAAATGAAGGGTTCACTATATTGATGCAGAGGCAAG
TCGTATTATCAGAGGAAGAGGCAAGAGCAGTGTGCCACGTCCATGAGGATGAAGACTATTTTGA
TAATCTTATAGGATACATGTGCAGTAATAACTCTTATATCCTTGTTCTAATGAGGGAACATAGT
GTGGAACGTTGGAAAGAGTTAATCGGGCCTAAAACTGTTGAGGAGGCTTATGCATCTCATCCAG
ACAGTTTATGTGTACGGTTTGCTTCAGGAAATTTTCCTGTCAACCAGTTCTATGGGAGCAGTTC
AAAAGCAGCAGCTGAGACAGAAATAGAGCATTTCTTTCCTCCTCAGAGTACGCTGGCATTGATT
AAGCCTCACGTGTCACACAAAGAAAGAATGGAGATTCTGAAGGCCATTAGAGATGCAAGATTTG
AGCTGACCCAGATGAAAGAAATGCACCTGACTCCGGAGCATGCAAGCAAAGTTTATTTCAAAAT
AACAGGAAAAGATTTCTATAAAAATGTATTGGACGTCTTATCTTCGGGCATGTCAGTAGTCATG
ATTCTGACCAAGTGGAATGCTGTTGGAGAATGGAGGCGAATGATGGGCCCAGTAGACCCAGAAG
AAGCAAAACTGCTGTCTCCAAATTCCCTCCGAGCCAGATATGGAATAGACGTTTTGAGAAATGC
TGTCCATGGGGCATCTAACATGTCTGAAGCAGCAACTGCCATTAGTAATGTGTTCACAGAGAGC
AATTTTGAGAACTAGGACAAATACTAGAAAACTCAATGAGATAATGAAGAAGTTTCATCACATA
AAACCATGAGGCACAACTTCCTGTAAAGAGTAAGAACAAAAATTTCTCCAAGAGAAACACACAT
GGAGATGAAAACTCGCATGGCTATGCATGGTAACAATAAAAACTGTAACCCCCCAA

hide sequence

RefSeq Acc Id:

XM_017600637 ⟹ XP_017456126

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	49,933,756 - 50,000,610 (+)	NCBI
mRatBN7.2	17	45,238,090 - 45,304,948 (+)	NCBI
Rnor_6.0	17	47,301,473 - 47,368,543 (+)	NCBI

Sequence:

show sequence

GGGCTGAACGTTGGTGTCTTTGCCTTTCCTTTTCCAGGGGGTGATGCCAGGCATCCCTCATCCC
CTCCTTTAACTGGACCTGCTGGGGAAGAAGGCACAGCAGGAACCCTGCCACCTTTAGCCTGAGC
CTGACCCAGAACTGGTCCAGCAGACAAATGGCAAGCAAAAAACGTGAAGTCCAGCTACAGTCAG
TCGTCAATAGTCAGAACTTGTGGGATGAGATGTTGCTGAACAAAGGCTTAACAGTGATTGATGT
ATACCAAGCCTGGTGTGGACCCTGCAAAGCCGTGCAAGCTTTATTCAGAAAACTAAAAAATGAA
CTGAATGAAGATGAGCTTCTTCATTTTGTCGTTAATGGTAAAATTATTGCAAAGATTCAGGGTG
CAAATGCACCACTTATCAATAGAAAAGTCATTGCATTGATAGATGAAGAGAAGAAAATTGCAGC
AGGTGAAATGGCTCGTCCTCAGTATGTTGAAATTCCACTAGTAGACTCATTGGACGAAGAATAT
GGGGAAGTGCACTATGAAAGTAATGTGGAAGTTTACAATATGGCAGTTATCAACCCTGATGCTG
TACTCATGAGAAAAAATTTGGAAATTAAGGAAAAAATAACCAAAGAAGGATTTATCATAGAAAT
ACAGGAAAACATGCTTCTCCCCGAAGAGGTAGCGAGGGAATTCTACAATCATATGATAGATGAG
CCTGACTTTGAAGAGTTTGTATATTCTATGACAAACCGCCTAAGCTGTGTGCTCATTATATCTC
AAGGAGAAGACACAGAGGTTATTGAGGAGGAAGCTCTCCCTCAGTCTGATGATGAAGAAGAAGA
AGAAGAAGAAGAAGTAGTAGAAGAACCTGACCCTTTGGAAGAGCCTCACGTTAGGTTTGCACCT
ATGCTGGTAAAGAAGAAACGGGACAGTTTGCAAGAGTATATGGACCGACAACATATGTCTGATT
ACTGTCATGTCGAGGATGATGCGGTTAAGGTGTCCAAGTTCATTGACATATTATTCCCTGATTT
TAAAACCATGAAAAGCACGAATGTACAAAGGACACTAGGATTACTGTATCCAGAAGTCTGTGAG
GAAGAGAAAGATAATGTGTTGGACATTATTCAAAATGAAGGGTTCACTATATTGATGCAGAGGC
AAGTCGTATTATCAGAGGAAGAGGCAAGAGCAGTGTGCCACGTCCATGAGGATGAAGACTATTT
TGATAATCTTATAGGATACATGTGCAGTAATAACTCTTATATCCTTGTTCTAATGAGGGAACAT
AGTGTGGAACGTTGGAAAGAGTTAATCGGGCCTAAAACTGTTGAGGAGGCTTATGCATCTCATC
CAGACAGTTTATGTGTACGGTTTGCTTCAGGAAATTTTCCTGTCAACCAGTTCTATGGGAGCAG
TTCAAAAGCAGCAGCTGAGACAGAAATAGAGCATTTCTTTCCTCCTCAGAGTACGCTGGCATTG
ATTAAGCCTCACGTGTCACACAAAGAAAGAATGGAGATTCTGAAGGCCATTAGAGATGCAAGAT
TTGAGCTGACCCAGATGAAAGAAATGCACCTGACTCCGGAGCATGCAAGCAAAGTTTATTTCAA
AATAACAGGAAAAGATTTCTATAAAAATGTATTGGACGTCTTATCTTCGGGCATGTCAGTAGTC
ATGATTCTGACCAAGTGGAATGCTGTTGGAGAATGGAGGCGAATGATGGGCCCAGTAGACCCAG
AAGAAGCAAAACTGCTGTCTCCAAATTCCCTCCGAGCCAGATATGGAATAGACGTTTTGAGAAA
TGCTGTCCATGGGGCATCTAACATGTCTGAAGCAGCAACTGCCATTAGTAATGTGTTCACAGAG
AGCAATTTTGAGAACTAGGACAAATACTAGAAAACTCAATGAGATAATGAAGAAGTTTCATCAC
ATAAAACCATGAGGCACAACTTCCTGTAAAGAGTAAGAACAAAAATTTCTCCAAGAGAAACACA
CATGGAGATGAAAACTCGCATGGCTATGCATGGTAACAATAAAAACTGTAACCCCCCAA

hide sequence

RefSeq Acc Id:

XM_039095975 ⟹ XP_038951903

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	49,932,884 - 50,000,610 (+)	NCBI
mRatBN7.2	17	45,237,424 - 45,304,948 (+)	NCBI

RefSeq Acc Id:

XM_039095976 ⟹ XP_038951904

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	49,932,884 - 50,000,610 (+)	NCBI
mRatBN7.2	17	45,237,025 - 45,304,948 (+)	NCBI

RefSeq Acc Id:

XM_039095978 ⟹ XP_038951906

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	49,940,331 - 50,000,610 (+)	NCBI
mRatBN7.2	17	45,244,665 - 45,304,948 (+)	NCBI

RefSeq Acc Id:

XM_039095979 ⟹ XP_038951907

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	49,933,756 - 49,969,645 (+)	NCBI
mRatBN7.2	17	45,238,090 - 45,273,980 (+)	NCBI

RefSeq Acc Id:

XM_063276669 ⟹ XP_063132739

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	49,932,884 - 50,000,610 (+)	NCBI

RefSeq Acc Id:

XM_063276670 ⟹ XP_063132740

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	49,932,884 - 50,000,610 (+)	NCBI

RefSeq Acc Id:

XM_063276671 ⟹ XP_063132741

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	49,934,902 - 50,000,610 (+)	NCBI

RefSeq Acc Id:

XR_005495310

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	49,933,756 - 50,000,610 (+)	NCBI
mRatBN7.2	17	45,238,090 - 45,304,948 (+)	NCBI

RefSeq Acc Id:

XR_010058906

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	49,933,756 - 50,000,610 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_942087	(Get FASTA)	NCBI Sequence Viewer
	XP_017456125	(Get FASTA)	NCBI Sequence Viewer
	XP_017456126	(Get FASTA)	NCBI Sequence Viewer
	XP_038951903	(Get FASTA)	NCBI Sequence Viewer
	XP_038951904	(Get FASTA)	NCBI Sequence Viewer
	XP_038951906	(Get FASTA)	NCBI Sequence Viewer
	XP_038951907	(Get FASTA)	NCBI Sequence Viewer
	XP_063132739	(Get FASTA)	NCBI Sequence Viewer
	XP_063132740	(Get FASTA)	NCBI Sequence Viewer
	XP_063132741	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97265	(Get FASTA)	NCBI Sequence Viewer
	AAQ12344	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000068777
	ENSRNOP00000069890
GenBank Protein	Q715S9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_942087 ⟸ NM_198792

- UniProtKB:

F7EU06 (UniProtKB/TrEMBL), A0A8L2R1L1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASKKREVQLQSVVNSQNLWDEMLLNKGLTVIDVYQAWCGPCKAVQALFRKLKNELNEDELLHF
VVAEADSIVTLQPFRDKCEPVFLFSLNGKIIAKIQGANAPLINRKVIALIDEEKKIAAGEMARP
QYVEIPLVDSLDEEYGEVHYESNVEVYNMAVINPDAVLMRKNLEIKEKITKEGFIIEIQENMLL
PEEVAREFYNHMIDEPDFEEFVYSMTNRLSCVLIISQGEDTEVIEEEALPQSDDEEEEEEEEVV
EEPDPLEEPHVRFAPMLVKKKRDSLQEYMDRQHMSDYCHVEDDAVKVSKFIDILFPDFKTMKST
NVQRTLGLLYPEVCEEEKDNVLDIIQNEGFTILMQRQVVLSEEEARAVCHVHEDEDYFDNLIGY
MCSNNSYILVLMREHSVERWKELIGPKTVEEAYASHPDSLCVRFASGNFPVNQFYGSSSKAAAE
TEIEHFFPPQSTLALIKPHVSHKERMEILKAIRDARFELTQMKEMHLTPEHASKVYFKITGKDF
YKNVLDVLSSGMSVVMILTKWNAVGEWRRMMGPVDPEEAKLLSPNSLRARYGIDVLRNAVHGAS
NMSEAATAISNVFTESNFEN

hide sequence

RefSeq Acc Id:	XP_017456125 ⟸ XM_017600636
- Peptide Label:	isoform X1
- UniProtKB:	F7EU06 (UniProtKB/TrEMBL), A0A8L2R1L1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASKKREVQLQSVVNSQNLWDEMLLNKGLTVIDVYQAWCGPCKAVQALFRKLKNELNEDELLHF VVAEADSIVTLQPFRDKCEPVFLFSLNGKIIAKIQGANAPLINRKVIALIDEEKKIAAGEMARP QYVEIPLVDSLDEEYGEVHYESNVEVYNMAVINPDAVLMRKNLEIKEKITKEGFIIEIQENMLL PEEVAREFYNHMIDEPDFEEFVYSMTNRLSCVLIISQGEDTEVIEEEALPQSDDEEEEEEEEVV EEPDPLEEPHVRFAPMLVKKKRDSLQEYMDRQHMSDYCHVEDDAVKVSKFIDILFPDFKTMKST NVQRTLGLLYPEVCEEEKDNVLDIIQNEGFTILMQRQVVLSEEEARAVCHVHEDEDYFDNLIGY MCSNNSYILVLMREHSVERWKELIGPKTVEEAYASHPDSLCVRFASGNFPVNQFYGSSSKAAAE TEIEHFFPPQSTLALIKPHVSHKERMEILKAIRDARFELTQMKEMHLTPEHASKVYFKITGKDF YKNVLDVLSSGMSVVMILTKWNAVGEWRRMMGPVDPEEAKLLSPNSLRARYGIDVLRNAVHGAS NMSEAATAISNVFTESNFEN hide sequence

RefSeq Acc Id:	XP_017456126 ⟸ XM_017600637
- Peptide Label:	isoform X2
- UniProtKB:	A0A8L2R1L1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASKKREVQLQSVVNSQNLWDEMLLNKGLTVIDVYQAWCGPCKAVQALFRKLKNELNEDELLHF VVNGKIIAKIQGANAPLINRKVIALIDEEKKIAAGEMARPQYVEIPLVDSLDEEYGEVHYESNV EVYNMAVINPDAVLMRKNLEIKEKITKEGFIIEIQENMLLPEEVAREFYNHMIDEPDFEEFVYS MTNRLSCVLIISQGEDTEVIEEEALPQSDDEEEEEEEEVVEEPDPLEEPHVRFAPMLVKKKRDS LQEYMDRQHMSDYCHVEDDAVKVSKFIDILFPDFKTMKSTNVQRTLGLLYPEVCEEEKDNVLDI IQNEGFTILMQRQVVLSEEEARAVCHVHEDEDYFDNLIGYMCSNNSYILVLMREHSVERWKELI GPKTVEEAYASHPDSLCVRFASGNFPVNQFYGSSSKAAAETEIEHFFPPQSTLALIKPHVSHKE RMEILKAIRDARFELTQMKEMHLTPEHASKVYFKITGKDFYKNVLDVLSSGMSVVMILTKWNAV GEWRRMMGPVDPEEAKLLSPNSLRARYGIDVLRNAVHGASNMSEAATAISNVFTESNFEN hide sequence

Ensembl Acc Id:

ENSRNOP00000069890 ⟸ ENSRNOT00000092051

Ensembl Acc Id:

ENSRNOP00000068777 ⟸ ENSRNOT00000090021

Ensembl Acc Id:

ENSRNOP00000074097 ⟸ ENSRNOT00000087178

RefSeq Acc Id:	XP_038951904 ⟸ XM_039095976
- Peptide Label:	isoform X1
- UniProtKB:	F7EU06 (UniProtKB/TrEMBL), A0A8L2R1L1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038951903 ⟸ XM_039095975
- Peptide Label:	isoform X1
- UniProtKB:	F7EU06 (UniProtKB/TrEMBL), A0A8L2R1L1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038951907 ⟸ XM_039095979
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038951906 ⟸ XM_039095978
- Peptide Label:	isoform X4

Ensembl Acc Id:

ENSRNOP00000091968 ⟸ ENSRNOT00000113182

Ensembl Acc Id:

ENSRNOP00000096759 ⟸ ENSRNOT00000095832

RefSeq Acc Id:	XP_063132739 ⟸ XM_063276669
- Peptide Label:	isoform X2
- UniProtKB:	A0A8L2R1L1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063132740 ⟸ XM_063276670
- Peptide Label:	isoform X2
- UniProtKB:	A0A8L2R1L1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063132741 ⟸ XM_063276671
- Peptide Label:	isoform X3

Protein Domains

Thioredoxin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q715S9-F1-model_v2	AlphaFold	Q715S9	1-587	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700501

Promoter ID:

EPDNEW_R11023

Type:

single initiation site

Name:

Nme8_1

Description:

NME/NM23 family member 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	47,301,488 - 47,301,548	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735069	AgrOrtholog
BioCyc Gene	G2FUF-9148	BioCyc
Ensembl Genes	ENSRNOG00000058285	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000090021	ENTREZGENE
	ENSRNOT00000092051	ENTREZGENE
Gene3D-CATH	3.30.70.141	UniProtKB/Swiss-Prot
	Glutaredoxin	UniProtKB/Swiss-Prot
InterPro	NDK-like_dom	UniProtKB/Swiss-Prot
	NDK-like_dom_sf	UniProtKB/Swiss-Prot
	Thioredoxin-like_sf	UniProtKB/Swiss-Prot
	Thioredoxin_CS	UniProtKB/Swiss-Prot
	Thioredoxin_domain	UniProtKB/Swiss-Prot
	TXND_domain-containing	UniProtKB/Swiss-Prot
NCBI Gene	364729	ENTREZGENE
PANTHER	NME/NM23 FAMILY MEMBER 8	UniProtKB/Swiss-Prot
	THIOREDOXIN DOMAIN-CONTAINING PROTEIN 3	UniProtKB/Swiss-Prot
Pfam	NDK	UniProtKB/Swiss-Prot
	Thioredoxin	UniProtKB/Swiss-Prot
PhenoGen	Nme8	PhenoGen
PROSITE	NDPK_LIKE	UniProtKB/Swiss-Prot
	THIOREDOXIN_1	UniProtKB/Swiss-Prot
	THIOREDOXIN_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000058285	RatGTEx
SMART	NDK	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52833	UniProtKB/Swiss-Prot
	SSF54919	UniProtKB/Swiss-Prot
UniProt	A0A8L2R1L1	ENTREZGENE, UniProtKB/TrEMBL
	F7EU06	ENTREZGENE, UniProtKB/TrEMBL
	Q4V8P5_RAT	UniProtKB/TrEMBL
	Q715S9	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-17	Nme8	NME/NM23 family member 8	Txndc3	thioredoxin domain containing 3 (spermatozoa)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Txndc3	thioredoxin domain containing 3 (spermatozoa)		thioredoxin domain containing 3	Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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