Csnk1a1 (casein kinase 1, alpha 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Csnk1a1 (casein kinase 1, alpha 1) Rattus norvegicus
Analyze
Symbol: Csnk1a1
Name: casein kinase 1, alpha 1
RGD ID: 71098
Description: Enables several functions, including ATP binding activity; magnesium ion binding activity; and phosphoprotein binding activity. Involved in negative regulation of canonical Wnt signaling pathway. Located in nuclear speck. Orthologous to human CSNK1A1 (casein kinase 1 alpha 1); PARTICIPATES IN dopamine signaling pathway; Hedgehog signaling pathway; p53 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: casein kinase I; casein kinase I isoform alpha; CK1; CKI-alpha; MGC156603
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81857,285,156 - 57,320,540 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1857,287,412 - 57,320,538 (+)EnsemblGRCr8
mRatBN7.21855,017,049 - 55,050,184 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1855,017,055 - 55,049,271 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1857,110,855 - 57,142,124 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,825,472 - 57,856,741 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,640,937 - 55,672,070 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,887,722 - 56,910,610 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,887,354 - 56,918,345 (+)Ensemblrn6Rnor6.0
Rnor_5.01856,116,635 - 56,139,523 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41857,541,673 - 57,564,560 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1853,168,136 - 53,191,023 (+)NCBICelera
RGSC_v3.11857,613,904 - 57,636,793 (+)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
atrazine  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbonyl sulfide  (EXP)
casticin  (ISO)
CGP 52608  (ISO)
chlormequat chloride  (EXP)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
Evodiamine  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lenalidomide  (ISO)
levonorgestrel  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
piroxicam  (ISO)
pyrvinium  (ISO)
quinacrine  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sunitinib  (ISO)
testosterone undecanoate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Opioid receptor agonists enhance the phosphorylation state of Fas-associated death domain (FADD) protein in the rat brain: functional interactions with casein kinase Ialpha, Galpha(i) proteins, and ERK1/2 signaling. Garcia-Fuster MJ, etal., Neuropharmacology. 2008 Oct;55(5):886-99. doi: 10.1016/j.neuropharm.2008.06.071. Epub 2008 Jul 9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease. Ghoshal N, etal., Am J Pathol. 1999 Oct;155(4):1163-72.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs. Gonzales ML, etal., J Biol Chem. 2008 May 2;283(18):12665-73. doi: 10.1074/jbc.M800656200. Epub 2008 Feb 27.
6. The casein kinase Ialpha isoform is both physically positioned and functionally competent to regulate multiple events of mRNA metabolism. Gross SD, etal., J Cell Sci. 1999 Aug;112 ( Pt 16):2647-56.
7. Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis. Kannanayakal TJ, etal., Neurosci Lett. 2008 Jan 31;431(2):141-5. doi: 10.1016/j.neulet.2007.11.066. Epub 2007 Dec 15.
8. Wnt signalling and its impact on development and cancer. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
9. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Liu C, etal., Cell. 2002 Mar 22;108(6):837-47.
10. Gene Data Set MGD Curation, June 12, 2002
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
19. Casein kinase I alpha and alpha L: alternative splicing-generated kinases exhibit different catalytic properties. Zhang J, etal., Biochemistry 1996 Dec 17;35(50):16319-27.
Additional References at PubMed
PMID:12477932   PMID:14681019   PMID:15896722   PMID:17686994   PMID:19364825   PMID:19946888   PMID:20067794   PMID:21331045   PMID:21399614   PMID:21709260   PMID:21930935   PMID:22871113  
PMID:23902688   PMID:24760862   PMID:25500533   PMID:25644602  


Genomics

Comparative Map Data
Csnk1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81857,285,156 - 57,320,540 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1857,287,412 - 57,320,538 (+)EnsemblGRCr8
mRatBN7.21855,017,049 - 55,050,184 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1855,017,055 - 55,049,271 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1857,110,855 - 57,142,124 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,825,472 - 57,856,741 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,640,937 - 55,672,070 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,887,722 - 56,910,610 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,887,354 - 56,918,345 (+)Ensemblrn6Rnor6.0
Rnor_5.01856,116,635 - 56,139,523 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41857,541,673 - 57,564,560 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1853,168,136 - 53,191,023 (+)NCBICelera
RGSC_v3.11857,613,904 - 57,636,793 (+)NCBI
Cytogenetic Map18q12.1NCBI
CSNK1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385149,492,982 - 149,551,439 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5149,492,982 - 149,551,471 (-)Ensemblhg38GRCh38
GRCh375148,872,545 - 148,931,002 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,855,038 - 148,911,200 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345148,855,741 - 148,910,850NCBI
Celera5144,956,788 - 145,012,931 (-)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5144,021,796 - 144,077,664 (-)NCBIHuRef
CHM1_15148,307,871 - 148,363,537 (-)NCBICHM1_1
T2T-CHM13v2.05150,027,795 - 150,086,185 (-)NCBIT2T-CHM13v2.0
Csnk1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,687,307 - 61,723,391 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,688,345 - 61,723,132 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381861,554,236 - 61,590,320 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,555,274 - 61,590,061 (+)Ensemblmm10GRCm38
MGSCv371861,715,236 - 61,747,953 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361861,680,951 - 61,713,668 (+)NCBIMGSCv36mm8
Celera1862,838,154 - 62,870,841 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.62NCBI
Csnk1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554154,921,852 - 4,966,705 (+)Ensembl
ChiLan1.0NW_0049554154,921,356 - 4,966,705 (+)NCBIChiLan1.0ChiLan1.0
CSNK1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24144,724,209 - 144,781,337 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15142,863,758 - 142,920,361 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05144,919,775 - 144,977,105 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15150,929,397 - 150,985,930 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5150,929,420 - 150,985,912 (-)EnsemblpanPan2panpan1.1
CSNK1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1459,435,530 - 59,485,591 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,435,764 - 59,483,475 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha459,200,573 - 59,251,121 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0459,917,581 - 59,968,297 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,917,668 - 59,968,538 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,704,847 - 59,755,283 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,818,995 - 59,869,549 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0460,349,721 - 60,400,321 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Csnk1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213143,777,433 - 143,820,877 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365045,351,029 - 5,396,034 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365045,351,354 - 5,394,856 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSNK1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,612,077 - 150,662,284 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12150,612,845 - 150,662,431 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22157,378,846 - 157,428,423 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CSNK1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12352,111,500 - 52,169,043 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2352,114,053 - 52,168,998 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603425,552,342 - 25,611,260 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Csnk1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247748,815,023 - 8,862,878 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247748,815,021 - 8,862,657 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Csnk1a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11570,359,284 - 70,392,427 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Csnk1a1
125 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:637
Count of miRNA genes:258
Interacting mature miRNAs:329
Transcripts:ENSRNOT00000044346, ENSRNOT00000066133
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184891705460064728Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185384517561982387Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
X90945  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21855,047,422 - 55,047,578 (+)MAPPERmRatBN7.2
Rnor_6.01856,917,597 - 56,917,752NCBIRnor6.0
Rnor_5.01856,146,510 - 56,146,665UniSTSRnor5.0
RGSC_v3.41857,571,548 - 57,571,703UniSTSRGSC3.4
Celera1853,198,010 - 53,198,165UniSTS
Cytogenetic Map18q12.1UniSTS
RH144160  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21855,042,536 - 55,042,744 (+)MAPPERmRatBN7.2
Rnor_6.01856,912,711 - 56,912,918NCBIRnor6.0
Rnor_5.01856,141,624 - 56,141,831UniSTSRnor5.0
RGSC_v3.41857,566,662 - 57,566,869UniSTSRGSC3.4
Celera1853,193,124 - 53,193,331UniSTS
RH 3.4 Map18540.3UniSTS
Cytogenetic Map18q12.1UniSTS
BE111197  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21855,045,347 - 55,045,525 (+)MAPPERmRatBN7.2
Rnor_6.01856,915,522 - 56,915,699NCBIRnor6.0
Rnor_5.01856,144,435 - 56,144,612UniSTSRnor5.0
RGSC_v3.41857,569,473 - 57,569,650UniSTSRGSC3.4
Celera1853,195,935 - 53,196,112UniSTS
RH 3.4 Map18543.8UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC127486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U77582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U77583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000044346   ⟹   ENSRNOP00000051516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,287,412 - 57,315,679 (+)Ensembl
mRatBN7.2 Ensembl1855,017,055 - 55,049,271 (+)Ensembl
Rnor_6.0 Ensembl1856,887,354 - 56,917,711 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000066133   ⟹   ENSRNOP00000062327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1856,887,496 - 56,918,345 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078783   ⟹   ENSRNOP00000072385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1856,887,722 - 56,910,901 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097100   ⟹   ENSRNOP00000085265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1855,017,055 - 55,049,271 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103047   ⟹   ENSRNOP00000082592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1855,017,055 - 55,049,271 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000130756   ⟹   ENSRNOP00000104504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,287,446 - 57,318,696 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000148420   ⟹   ENSRNOP00000101687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,287,458 - 57,320,538 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000165873   ⟹   ENSRNOP00000106476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,287,496 - 57,312,080 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000167200   ⟹   ENSRNOP00000104017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,287,463 - 57,320,538 (+)Ensembl
RefSeq Acc Id: NM_053615   ⟹   NP_446067
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81857,287,412 - 57,318,551 (+)NCBI
mRatBN7.21855,017,053 - 55,048,195 (+)NCBI
Rnor_6.01856,887,722 - 56,910,610 (+)NCBI
Rnor_5.01856,116,635 - 56,139,523 (+)NCBI
RGSC_v3.41857,541,673 - 57,564,560 (+)RGD
Celera1853,168,136 - 53,191,023 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096533   ⟹   XP_038952461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81857,287,340 - 57,315,929 (+)NCBI
mRatBN7.21855,017,049 - 55,043,822 (+)NCBI
RefSeq Acc Id: XM_039096535   ⟹   XP_038952463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81857,287,340 - 57,320,540 (+)NCBI
mRatBN7.21855,017,051 - 55,050,184 (+)NCBI
RefSeq Acc Id: XM_039096536   ⟹   XP_038952464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81857,287,340 - 57,320,540 (+)NCBI
mRatBN7.21855,017,049 - 55,043,822 (+)NCBI
RefSeq Acc Id: XM_039096537   ⟹   XP_038952465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81857,287,340 - 57,320,540 (+)NCBI
mRatBN7.21855,017,051 - 55,050,184 (+)NCBI
RefSeq Acc Id: XM_039096538   ⟹   XP_038952466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81857,287,325 - 57,320,540 (+)NCBI
mRatBN7.21855,017,054 - 55,043,822 (+)NCBI
RefSeq Acc Id: XM_039096541   ⟹   XP_038952469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81857,287,325 - 57,320,540 (+)NCBI
mRatBN7.21855,017,054 - 55,050,184 (+)NCBI
RefSeq Acc Id: XM_063277052   ⟹   XP_063133122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81857,287,340 - 57,320,540 (+)NCBI
RefSeq Acc Id: XM_063277053   ⟹   XP_063133123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81857,287,340 - 57,320,540 (+)NCBI
RefSeq Acc Id: XM_063277054   ⟹   XP_063133124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81857,287,325 - 57,320,540 (+)NCBI
RefSeq Acc Id: XM_063277055   ⟹   XP_063133125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81857,285,156 - 57,320,540 (+)NCBI
RefSeq Acc Id: NP_446067   ⟸   NM_053615
- UniProtKB: A0JPL2 (UniProtKB/TrEMBL),   A6IXH5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062327   ⟸   ENSRNOT00000066133
Ensembl Acc Id: ENSRNOP00000051516   ⟸   ENSRNOT00000044346
Ensembl Acc Id: ENSRNOP00000072385   ⟸   ENSRNOT00000078783
RefSeq Acc Id: XP_038952461   ⟸   XM_039096533
- Peptide Label: isoform X1
- UniProtKB: A6IXH5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952464   ⟸   XM_039096536
- Peptide Label: isoform X4
- UniProtKB: P97634 (UniProtKB/Swiss-Prot),   P97633 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038952463   ⟸   XM_039096535
- Peptide Label: isoform X3
- UniProtKB: A6IXH5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952465   ⟸   XM_039096537
- Peptide Label: isoform X5
- UniProtKB: P97634 (UniProtKB/Swiss-Prot),   P97633 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038952469   ⟸   XM_039096541
- Peptide Label: isoform X9
- UniProtKB: P97634 (UniProtKB/Swiss-Prot),   P97633 (UniProtKB/Swiss-Prot),   A6IXH7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952466   ⟸   XM_039096538
- Peptide Label: isoform X6
- UniProtKB: A6IXH5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085265   ⟸   ENSRNOT00000097100
Ensembl Acc Id: ENSRNOP00000082592   ⟸   ENSRNOT00000103047
RefSeq Acc Id: XP_063133125   ⟸   XM_063277055
- Peptide Label: isoform X8
- UniProtKB: P97634 (UniProtKB/Swiss-Prot),   P97633 (UniProtKB/Swiss-Prot),   D3ZRE3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133124   ⟸   XM_063277054
- Peptide Label: isoform X7
- UniProtKB: A6IXH5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133122   ⟸   XM_063277052
- Peptide Label: isoform X1
- UniProtKB: A6IXH5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133123   ⟸   XM_063277053
- Peptide Label: isoform X2
- UniProtKB: A6IXH5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101687   ⟸   ENSRNOT00000148420
Ensembl Acc Id: ENSRNOP00000104017   ⟸   ENSRNOT00000167200
Ensembl Acc Id: ENSRNOP00000104504   ⟸   ENSRNOT00000130756
Ensembl Acc Id: ENSRNOP00000106476   ⟸   ENSRNOT00000165873
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97633-F1-model_v2 AlphaFold P97633 1-325 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700823
Promoter ID:EPDNEW_R11341
Type:initiation region
Name:Csnk1a1_1
Description:casein kinase 1, alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01856,887,263 - 56,887,323EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71098 AgrOrtholog
BioCyc Gene G2FUF-7324 BioCyc
Ensembl Genes ENSRNOG00000017106 Ensembl
  ENSRNOG00000063313 Ensembl
  ENSRNOG00000072163 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000148420 ENTREZGENE
  ENSRNOT00000167200 ENTREZGENE
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8364080 IMAGE-MGC_LOAD
InterPro CK1_Ser-Thr_kinase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:113927 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156603 IMAGE-MGC_LOAD
NCBI Gene 113927 ENTREZGENE
PANTHER CASEIN KINASE-RELATED UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Csnk1a1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017106 RatGTEx
  ENSRNOG00000063313 RatGTEx
  ENSRNOG00000072163 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0ABK0L4K7_RAT UniProtKB/TrEMBL
  A0ABK0L909_RAT UniProtKB/TrEMBL
  A0ABK0LI34_RAT UniProtKB/TrEMBL
  A0ABK0LL64_RAT UniProtKB/TrEMBL
  A0JPL2 ENTREZGENE, UniProtKB/TrEMBL
  A6IXH4_RAT UniProtKB/TrEMBL
  A6IXH5 ENTREZGENE, UniProtKB/TrEMBL
  A6IXH7 ENTREZGENE, UniProtKB/TrEMBL
  A6IXH9_RAT UniProtKB/TrEMBL
  A6IXI0_RAT UniProtKB/TrEMBL
  A6IXI1_RAT UniProtKB/TrEMBL
  D3ZRE3 ENTREZGENE, UniProtKB/TrEMBL
  KC1A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P97634 ENTREZGENE
UniProt Secondary P97634 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Csnk1a1  casein kinase 1, alpha 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein splice variant CKI alpha L contains an insertion within the catalytic site 70700
gene_transcript CKI alpha and CKI alpha L are alternatively spliced isoforms 70700