Grpel1 (GrpE-like 1, mitochondrial) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Grpel1 (GrpE-like 1, mitochondrial) Rattus norvegicus
Analyze
Symbol: Grpel1
Name: GrpE-like 1, mitochondrial
RGD ID: 70947
Description: Enables ATPase activator activity; ATPase binding activity; and identical protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to be located in mitochondrial matrix and nucleoplasm. Predicted to be part of PAM complex, Tim23 associated import motor. Biomarker of middle cerebral artery infarction. Orthologous to human GRPEL1 (GrpE like 1, mitochondrial); PARTICIPATES IN presequence pathway of mitochondrial protein import; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2-nitrofluorene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: grpE protein homolog 1, mitochondrial; GrpE#1; GrpE1; mt-GrpE#1; stress-inducible chaperone mt-GrpE#1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81478,517,049 - 78,522,868 (-)NCBIGRCr8
mRatBN7.21474,292,023 - 74,298,243 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1474,292,023 - 74,298,200 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1478,734,419 - 78,740,226 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01479,975,292 - 79,981,099 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01476,420,265 - 76,426,072 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01479,458,951 - 79,464,782 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1479,458,963 - 79,464,770 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01479,097,953 - 79,103,777 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41479,873,191 - 79,878,998 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11479,875,225 - 79,881,387 (-)NCBI
Celera1473,230,590 - 73,236,397 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
adenine  (ISO)
aflatoxin B1  (EXP)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
hydroxyurea  (ISO)
isobutanol  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
limonene  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
sodium dichromate  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE. Choglay AA, etal., Gene 2001 Apr 4;267(1):125-34.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Gene Data Set MGD Curation, June 12, 2002
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Isolation and characterisation of a cDNA encoding rat mitochondrial GrpE, a stress-inducible nucleotide-exchange factor of ubiquitous appearance in mammalian organs. Naylor DJ, etal., FEBS Lett 1996 Nov 4;396(2-3):181-8.
7. Evidence for the existence of distinct mammalian cytosolic, microsomal, and two mitochondrial GrpE-like proteins, the Co-chaperones of specific Hsp70 members. Naylor DJ, etal., J Biol Chem. 1998 Aug 14;273(33):21169-77.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Unlocking the presequence import pathway. Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
13. Induction of heat shock protein 40 and GrpE mRNAs following transient focal cerebral ischemia in the rat. Tamura S, etal., Brain Res 2003 Jan 17;960(1-2):277-81.
Additional References at PubMed
PMID:11311562   PMID:12477932   PMID:14651853   PMID:18614015   PMID:25002582  


Genomics

Comparative Map Data
Grpel1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81478,517,049 - 78,522,868 (-)NCBIGRCr8
mRatBN7.21474,292,023 - 74,298,243 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1474,292,023 - 74,298,200 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1478,734,419 - 78,740,226 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01479,975,292 - 79,981,099 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01476,420,265 - 76,426,072 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01479,458,951 - 79,464,782 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1479,458,963 - 79,464,770 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01479,097,953 - 79,103,777 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41479,873,191 - 79,878,998 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11479,875,225 - 79,881,387 (-)NCBI
Celera1473,230,590 - 73,236,397 (-)NCBICelera
Cytogenetic Map14q21NCBI
GRPEL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3847,058,895 - 7,068,064 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl47,058,671 - 7,068,085 (-)EnsemblGRCh38hg38GRCh38
GRCh3747,060,622 - 7,069,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3647,112,681 - 7,120,701 (-)NCBINCBI36Build 36hg18NCBI36
Build 3447,179,851 - 7,187,872NCBI
Celera46,965,198 - 6,973,219 (-)NCBICelera
Cytogenetic Map4p16.1NCBI
HuRef46,989,046 - 6,997,061 (-)NCBIHuRef
CHM1_147,060,163 - 7,068,180 (-)NCBICHM1_1
T2T-CHM13v2.047,030,735 - 7,039,901 (-)NCBIT2T-CHM13v2.0
Grpel1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39536,622,529 - 36,631,421 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl536,622,342 - 36,631,424 (+)EnsemblGRCm39 Ensembl
GRCm38536,465,185 - 36,474,077 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl536,464,998 - 36,474,080 (+)EnsemblGRCm38mm10GRCm38
MGSCv37536,807,834 - 36,816,726 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36536,782,280 - 36,791,172 (+)NCBIMGSCv36mm8
Celera533,946,160 - 33,955,052 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map519.14NCBI
Grpel1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555143,459,774 - 3,467,279 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555143,459,774 - 3,467,279 (+)NCBIChiLan1.0ChiLan1.0
GRPEL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v237,326,364 - 7,334,615 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan147,255,405 - 7,263,644 (-)NCBINHGRI_mPanPan1
PanPan1.147,126,043 - 7,135,388 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl47,126,043 - 7,135,388 (-)Ensemblpanpan1.1panPan2
GRPEL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1359,124,116 - 59,131,541 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl359,124,613 - 59,131,977 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha361,770,979 - 61,778,423 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0359,595,959 - 59,603,388 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl359,595,274 - 59,603,595 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1359,093,027 - 59,100,454 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0359,294,915 - 59,302,364 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0359,649,262 - 59,656,689 (-)NCBIUU_Cfam_GSD_1.0
Grpel1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528565,181,864 - 65,189,477 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647718,880,736 - 18,891,110 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647718,883,556 - 18,891,108 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRPEL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.183,797,310 - 3,813,725 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.283,397,261 - 3,413,692 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRPEL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12743,173,664 - 43,182,015 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2743,174,467 - 43,181,783 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604790,028,597 - 90,036,905 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grpel1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475523,270,910 - 23,280,264 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475523,273,253 - 23,280,328 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grpel1
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:462
Count of miRNA genes:245
Interacting mature miRNAs:292
Transcripts:ENSRNOT00000008932
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat

Markers in Region
RH129769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21474,292,066 - 74,292,260 (+)MAPPERmRatBN7.2
Rnor_6.01479,458,650 - 79,458,843NCBIRnor6.0
Rnor_5.01479,097,652 - 79,097,845UniSTSRnor5.0
RGSC_v3.41479,872,878 - 79,873,071UniSTSRGSC3.4
Celera1473,230,277 - 73,230,470UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008932   ⟹   ENSRNOP00000008930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1474,292,023 - 74,298,200 (-)Ensembl
Rnor_6.0 Ensembl1479,458,963 - 79,464,770 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082180   ⟹   ENSRNOP00000070967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1474,292,371 - 74,298,180 (-)Ensembl
Rnor_6.0 Ensembl1479,459,057 - 79,462,080 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104564   ⟹   ENSRNOP00000093798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1474,292,023 - 74,295,055 (-)Ensembl
RefSeq Acc Id: NM_024487   ⟹   NP_077813
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,517,061 - 78,522,868 (-)NCBI
mRatBN7.21474,292,380 - 74,298,187 (-)NCBI
Rnor_6.01479,458,963 - 79,464,770 (-)NCBI
Rnor_5.01479,097,953 - 79,103,777 (-)NCBI
RGSC_v3.41479,873,191 - 79,878,998 (-)RGD
Celera1473,230,590 - 73,236,397 (-)RGD
Sequence:
RefSeq Acc Id: XM_063273663   ⟹   XP_063129733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,517,049 - 78,520,125 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_077813   ⟸   NM_024487
- Peptide Label: precursor
- UniProtKB: Q4QRA3 (UniProtKB/Swiss-Prot),   P97576 (UniProtKB/Swiss-Prot),   A6IJY3 (UniProtKB/TrEMBL),   A0A8I6AMG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008930   ⟸   ENSRNOT00000008932
RefSeq Acc Id: ENSRNOP00000070967   ⟸   ENSRNOT00000082180
RefSeq Acc Id: ENSRNOP00000093798   ⟸   ENSRNOT00000104564
RefSeq Acc Id: XP_063129733   ⟸   XM_063273663
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JZA2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97576-F1-model_v2 AlphaFold P97576 1-217 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699384
Promoter ID:EPDNEW_R9909
Type:multiple initiation site
Name:Grpel1_1
Description:GrpE-like 1, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01479,464,781 - 79,464,841EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70947 AgrOrtholog
Ensembl Genes ENSRNOG00000006593 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055016227 UniProtKB/Swiss-Prot
  ENSRNOG00060019562 UniProtKB/Swiss-Prot
  ENSRNOG00065032374 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008932 ENTREZGENE
  ENSRNOT00000008932.6 UniProtKB/Swiss-Prot
  ENSRNOT00000082180.2 UniProtKB/TrEMBL
  ENSRNOT00000104564.1 UniProtKB/TrEMBL
  ENSRNOT00055027536 UniProtKB/Swiss-Prot
  ENSRNOT00060033884 UniProtKB/Swiss-Prot
  ENSRNOT00065055738 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.22.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.20.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7387647 IMAGE-MGC_LOAD
InterPro GrpE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GrpE_coiled_coil UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GrpE_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79563 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114309 IMAGE-MGC_LOAD
NCBI Gene 79563 ENTREZGENE
PANTHER GRPE PROTEIN HOMOLOG 1, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR21237 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GrpE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grpel1 PhenoGen
PRINTS GRPEPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GRPE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006593 RatGTEx
  ENSRNOG00055016227 RatGTEx
  ENSRNOG00060019562 RatGTEx
  ENSRNOG00065032374 RatGTEx
Superfamily-SCOP SSF51064 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF58014 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JZA2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMG9 ENTREZGENE, UniProtKB/TrEMBL
  A6IJY3 ENTREZGENE, UniProtKB/TrEMBL
  GRPE1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4QRA3 ENTREZGENE
UniProt Secondary Q4QRA3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Grpel1  GrpE-like 1, mitochondrial      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process enhances the ATPase activity of the mitochondrial Hsp70 68707
gene_regulation expression only marginally increased in response to the proline analog L-azetidine 2-carboxylic acid 70756