RGD Reference Report - Induction of heat shock protein 40 and GrpE mRNAs following transient focal cerebral ischemia in the rat. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Induction of heat shock protein 40 and GrpE mRNAs following transient focal cerebral ischemia in the rat.

Authors: Tamura, S  Kinouchi, H  Izaki, K  Okubo, A  Sugawara, T  Kunizuka, H  Mizoi, K 
Citation: Tamura S, etal., Brain Res 2003 Jan 17;960(1-2):277-81.
RGD ID: 632868
Pubmed: PMID:12505684   (View Abstract at PubMed)

Cerebral ischemia is associated with the induction of several heat shock proteins (HSPs), but the effects on HSP40 and GrpE are less clear. The present study investigated the induction of Hsp40 and GrpE mRNAs following 30 min of middle cerebral artery occlusion in the rat model. Reverse transcription-polymerase chain reaction (PCR) and in situ hybridization analyses showed significant induction of both mRNAs in the ischemic cortex. These results demonstrate the synergic induction of HSP70 molecular chaperone machinery in cerebral ischemia.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GRPEL1Humanmiddle cerebral artery infarction  ISOGrpel1 (Rattus norvegicus)mRNA:increased expression:cerebral cortexRGD 
Grpel1Ratmiddle cerebral artery infarction  IEP mRNA:increased expression:cerebral cortexRGD 
Grpel1Mousemiddle cerebral artery infarction  ISOGrpel1 (Rattus norvegicus)mRNA:increased expression:cerebral cortexRGD 

Objects Annotated

Genes (Rattus norvegicus)
Grpel1  (GrpE-like 1, mitochondrial)

Genes (Mus musculus)
Grpel1  (GrpE-like 1, mitochondrial)

Genes (Homo sapiens)
GRPEL1  (GrpE like 1, mitochondrial)


Additional Information