GRPEL1 (GrpE like 1, mitochondrial)

Gene: GRPEL1 (GrpE like 1, mitochondrial) Sus scrofa

Analyze

Symbol:

GRPEL1

Name:

GrpE like 1, mitochondrial

RGD ID:

14228690

Description:

ENCODES a protein that exhibits ATPase activator activity (ortholog); ATPase binding (ortholog); identical protein binding (ortholog); INVOLVED IN protein folding (inferred); protein import into mitochondrial matrix (inferred); PARTICIPATES IN presequence pathway of mitochondrial protein import; ASSOCIATED WITH human immunodeficiency virus infectious disease (ortholog); middle cerebral artery infarction (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH deoxynivalenol

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

grpE protein homolog 1, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	8	3,797,310 - 3,813,725 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	3,397,261 - 3,413,692 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

human immunodeficiency virus infectious disease (ISO)

middle cerebral artery infarction (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

deoxynivalenol (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein folding (IEA)

protein import into mitochondrial matrix (IBA,IEA)

Cellular Component

mitochondrial matrix (IEA)

mitochondrion (IEA)

nucleoplasm (ISO)

PAM complex, Tim23 associated import motor (IBA,IEA)

Molecular Function

adenyl-nucleotide exchange factor activity (IBA,IEA)

ATPase activator activity (ISO)

ATPase binding (ISO)

identical protein binding (ISO)

protein binding (ISO)

protein homodimerization activity (IEA)

protein-folding chaperone binding (IEA)

unfolded protein binding (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

presequence pathway of mitochondrial protein import (ISO)

References

Additional References at PubMed

PMID:14681463	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

GRPEL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	8	3,797,310 - 3,813,725 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	3,397,261 - 3,413,692 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GRPEL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	7,058,895 - 7,068,064 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	7,058,671 - 7,068,085 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	7,060,622 - 7,069,791 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	7,112,681 - 7,120,701 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	7,179,851 - 7,187,872	NCBI
Celera	4	6,965,198 - 6,973,219 (-)	NCBI		Celera
Cytogenetic Map	4	p16.1	NCBI
HuRef	4	6,989,046 - 6,997,061 (-)	NCBI		HuRef
CHM1_1	4	7,060,163 - 7,068,180 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	7,030,735 - 7,039,901 (-)	NCBI		T2T-CHM13v2.0

Grpel1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	36,622,529 - 36,631,421 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	36,622,342 - 36,631,424 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	36,465,185 - 36,474,077 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	36,464,998 - 36,474,080 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	36,807,834 - 36,816,726 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	36,782,280 - 36,791,172 (+)	NCBI		MGSCv36	mm8
Celera	5	33,946,160 - 33,955,052 (+)	NCBI		Celera
Cytogenetic Map	5	B3	NCBI
cM Map	5	19.14	NCBI

Grpel1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	78,517,049 - 78,522,868 (-)	NCBI		GRCr8
mRatBN7.2	14	74,292,023 - 74,298,243 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	74,292,023 - 74,298,200 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	78,734,419 - 78,740,226 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	79,975,292 - 79,981,099 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	76,420,265 - 76,426,072 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	79,458,951 - 79,464,782 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	79,458,963 - 79,464,770 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	79,097,953 - 79,103,777 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	79,873,191 - 79,878,998 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	79,875,225 - 79,881,387 (-)	NCBI
Celera	14	73,230,590 - 73,236,397 (-)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

Grpel1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	3,459,774 - 3,467,279 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955514	3,459,774 - 3,467,279 (+)	NCBI	ChiLan1.0	ChiLan1.0

GRPEL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	7,326,364 - 7,334,615 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	7,255,405 - 7,263,644 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	4	7,126,043 - 7,135,388 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	7,126,043 - 7,135,388 (-)	Ensembl	panpan1.1		panPan2

GRPEL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	59,124,116 - 59,131,541 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	59,124,613 - 59,131,977 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	61,770,979 - 61,778,423 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	59,595,959 - 59,603,388 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	59,595,274 - 59,603,595 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	59,093,027 - 59,100,454 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	59,294,915 - 59,302,364 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	59,649,262 - 59,656,689 (-)	NCBI		UU_Cfam_GSD_1.0

Grpel1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	65,181,864 - 65,189,477 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	18,880,736 - 18,891,110 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	18,883,556 - 18,891,108 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GRPEL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	43,173,664 - 43,182,015 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	43,174,467 - 43,181,783 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	90,028,597 - 90,036,905 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Grpel1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	23,270,910 - 23,280,264 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624755	23,273,253 - 23,280,328 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in GRPEL1
677 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	9	4	3	5	2	22	2	2	3
Low	1					1		1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003356847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000063	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK238694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK390032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK400281	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP326684	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01017870	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_003356847 ⟹ XP_003356895

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	8	3,797,310 - 3,813,725 (+)	NCBI

Sequence:

show sequence

CCCGAGGGGGCGGGCCAGCGGCTCCCGCGCATGCCTGTGGCGCGCGCAGGGCTGACGGCGGCGG
CAGTCATGGCGGCTCCGTGTGTGAGGGTGGCGCGGCGCAGCCTCTCGGCTTTAGCGTTGTCTCT
CAGGCCCTCTCCCCGGCTGCTGTGCACAGCCACAAAACAGAAGAACAACGGCCAGAACTTGGAA
GAGGACGCGGGTCAGAATGAACAGAAGACAGATCTTCCCTCTACAGAGAAGACCCTCATGGAGG
AGAAGGTCAAGCTGGAAGAGCAGCTGAAGGAGGCCATGGAAAAATACAAGCGANGCTTGGCAGA
TACTGAGAACTTTCGGCAGAGGAGCCAAAAATTGGTGGAGGAAGCTAAACTCTATGGCATTCAG
GGCTTCTGCAAGGACCTGCTGGAGGTCGCAGACATCTTGGAGAAGGCGACACAGTCTGTCCCGA
AGGAAGAGATCAGAGACGACAACCCCCACCTGAAGAACCTCTACGAGGGGCTCCTGATGACCGA
GGCCCAGATCCAGAAGGTGTTCACCAAGCACGGCTTGCTCCGCCTGGACCCCCTGGGCGCCAAG
TTCGACCCGTACGAGCACGAGGCCTTGTTCCACACGCCGGTGGAGGGCAAGGAGCCGGGCACGG
TGGCGCTGGTTAACAAAGTGGGCTACAAGCTGCACGGGCGCACCCTGAGGCCCGCCCTGGTGGG
GGTGGTGAAGGAGGCCTAGCCGCCGCCAGGGCTGCTGGCGTTTGCAGGTGACTCTCAGAAGGCC
GGTTGTCTTTGCTCCTGCCAGTGCTTTGACCTTTCCCTGACCCCCGTTGGAAGGCTTCGGTCAC
CACGGCGCCACAGAACAGCAAGCCAGTTGCGCAGTCGTGTCAACAGACTGGAGCTGGGGAGTCG
TTCGTTGATTTTCCATGCATATTTATAGGTGGTGTGCTGACGGATCGCTGCCGGAGCCTCGGGT
GTCGTGAAAAACACTGTGTCTGCTCAGACTCTGGTGACCTCAGAGGGTTTGAGATGAATAAAAG
GTCGATGTCTGGCTAGCTGGCCGCGCCGCGCCTGTGTCCTGTGCGTCTCCTGCAGCACACGCGT
GCCCGGCCCGCCGCCTTCCATTCACGGAGGAAAGGCCCAAAGAGTTTAAACATTTTCTTGCCAA
GGAAAAGTTGATGCCTTGGCGAATCTGTTTGAGTTCAGTTACAGTCGGTCTCGAGGCTGCAAGG
GCGCCGTCTGGCTTTCGGCGATAAGGCCCCCCCTTAGCATTCATTTTGCCAGTAACTGAATCTG
ACAGAATCAGTCACTTTTGTCCTGTATCGTTCATCTATTTAAAGAAATGTTTAAATCTCTGCCC
CACTAATTAGTGGTGACCTGAGGGTATTTCCCCTCCTAAGATGGACTTTCCTAGAGATCCGAGA
ACCGCATGTTTGGTCTGTTTCAGTGTTGATTTTTAAACTTTATTTAAGAGGATTAAAGCCCTGA
CATGTTTATTTTCCTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003356895	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000041779
	ENSSSCP00000041779.2
	ENSSSCP00015041076.1
	ENSSSCP00025041138.1
	ENSSSCP00035001650.1
	ENSSSCP00040003253.1
	ENSSSCP00045034776.1
	ENSSSCP00050018281.1
	ENSSSCP00055003375.1
	ENSSSCP00065041804.1

RefSeq Acc Id:

XP_003356895 ⟸ XM_003356847

- UniProtKB:

A0A8D0PZ52 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPVARAGLTAAAVMAAPCVRVARRSLSALALSLRPSPRLLCTATKQKNNGQNLEEDAGQNEQKT
DLPSTEKTLMEEKVKLEEQLKEAMEKYKRXLADTENFRQRSQKLVEEAKLYGIQGFCKDLLEVA
DILEKATQSVPKEEIRDDNPHLKNLYEGLLMTEAQIQKVFTKHGLLRLDPLGAKFDPYEHEALF
HTPVEGKEPGTVALVNKVGYKLHGRTLRPALVGVVKEA

hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000037445	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015073869	UniProtKB/TrEMBL
	ENSSSCG00025068258	UniProtKB/TrEMBL
	ENSSSCG00035003893	UniProtKB/TrEMBL
	ENSSSCG00040006295	UniProtKB/TrEMBL
	ENSSSCG00045029301	UniProtKB/TrEMBL
	ENSSSCG00050033108	UniProtKB/TrEMBL
	ENSSSCG00055002331	UniProtKB/TrEMBL
	ENSSSCG00065069567	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000046389	ENTREZGENE
	ENSSSCT00000046389.3	UniProtKB/TrEMBL
	ENSSSCT00015099383.1	UniProtKB/TrEMBL
	ENSSSCT00025093759.1	UniProtKB/TrEMBL
	ENSSSCT00035004847.1	UniProtKB/TrEMBL
	ENSSSCT00040008284.1	UniProtKB/TrEMBL
	ENSSSCT00045049987.1	UniProtKB/TrEMBL
	ENSSSCT00050044406.1	UniProtKB/TrEMBL
	ENSSSCT00055004395.1	UniProtKB/TrEMBL
	ENSSSCT00065095519.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.22.10	UniProtKB/TrEMBL
	3.90.20.20	UniProtKB/TrEMBL
InterPro	GrpE	UniProtKB/TrEMBL
	GrpE_coiled_coil	UniProtKB/TrEMBL
	GrpE_head	UniProtKB/TrEMBL
KEGG Report	ssc:100622145	UniProtKB/TrEMBL
NCBI Gene	GRPEL1	ENTREZGENE
PANTHER	GRPE PROTEIN HOMOLOG 1, MITOCHONDRIAL	UniProtKB/TrEMBL
	PTHR21237	UniProtKB/TrEMBL
Pfam	GrpE	UniProtKB/TrEMBL
PRINTS	GRPEPROTEIN	UniProtKB/TrEMBL
PROSITE	GRPE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51064	UniProtKB/TrEMBL
	SSF58014	UniProtKB/TrEMBL
UniProt	A0A287AD92_PIG	UniProtKB/TrEMBL
	A0A8D0PZ52	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - CTD

RGD Manual Annotations