Camk2n2 (calcium/calmodulin-dependent protein kinase II inhibitor 2) - Rat Genome Database

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Gene: Camk2n2 (calcium/calmodulin-dependent protein kinase II inhibitor 2) Rattus norvegicus
Analyze
Symbol: Camk2n2
Name: calcium/calmodulin-dependent protein kinase II inhibitor 2
RGD ID: 708411
Description: Enables calcium-dependent protein kinase inhibitor activity and protein kinase binding activity. Predicted to be involved in regulation of synaptic plasticity. Predicted to be located in synapse. Orthologous to human CAMK2N2 (calcium/calmodulin dependent protein kinase II inhibitor 2); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CaM-KII inhibitory protein; caM-KIIN; caM-KIINbeta; LOC59314
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,792,112 - 93,796,153 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1193,794,095 - 93,795,222 (+)EnsemblGRCr8
mRatBN7.21180,289,702 - 80,290,829 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1189,012,394 - 89,013,521 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,665,813 - 81,666,940 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,726,878 - 80,728,005 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01183,975,430 - 83,976,557 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,975,367 - 83,976,588 (+)Ensemblrn6Rnor6.0
Rnor_5.01187,047,758 - 87,048,885 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41182,519,331 - 82,519,584 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1179,129,393 - 79,129,646 (+)NCBICelera
RGSC_v3.11182,576,919 - 82,577,173 (+)NCBI
Cytogenetic Map11q23NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
nucleus  (IEA)
synapse  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Characterization of a calmodulin kinase II inhibitor protein in brain. Chang BH, etal., Proc Natl Acad Sci U S A 1998 Sep 1;95(18):10890-5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Novel insights into CaMKII function and regulation during memory formation. Lucchesi W, etal., Brain Res Bull. 2011 Apr 25;85(1-2):2-8. doi: 10.1016/j.brainresbull.2010.10.009. Epub 2010 Nov 9.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Controlling the cell cycle: the role of calcium/calmodulin-stimulated protein kinases I and II. Skelding KA, etal., Cell Cycle. 2011 Feb 15;10(4):631-9. Epub 2011 Feb 15.
Additional References at PubMed
PMID:23051746   PMID:24520120  


Genomics

Comparative Map Data
Camk2n2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,792,112 - 93,796,153 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1193,794,095 - 93,795,222 (+)EnsemblGRCr8
mRatBN7.21180,289,702 - 80,290,829 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1189,012,394 - 89,013,521 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,665,813 - 81,666,940 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,726,878 - 80,728,005 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01183,975,430 - 83,976,557 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1183,975,367 - 83,976,588 (+)Ensemblrn6Rnor6.0
Rnor_5.01187,047,758 - 87,048,885 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41182,519,331 - 82,519,584 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1179,129,393 - 79,129,646 (+)NCBICelera
RGSC_v3.11182,576,919 - 82,577,173 (+)NCBI
Cytogenetic Map11q23NCBI
CAMK2N2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383184,259,213 - 184,261,553 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3184,259,213 - 184,261,553 (-)Ensemblhg38GRCh38
GRCh373183,977,001 - 183,979,341 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,459,697 - 185,461,945 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343185,460,473 - 185,461,953NCBI
Celera3182,417,767 - 182,420,015 (-)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3181,384,036 - 181,386,254 (-)NCBIHuRef
CHM1_13183,941,491 - 183,943,768 (-)NCBICHM1_1
T2T-CHM13v2.03187,068,515 - 187,070,855 (-)NCBIT2T-CHM13v2.0
Camk2n2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,437,965 - 20,440,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,437,965 - 20,440,037 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381620,619,215 - 20,621,278 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,619,215 - 20,621,287 (-)Ensemblmm10GRCm38
MGSCv371620,619,288 - 20,621,351 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361620,532,763 - 20,534,821 (-)NCBIMGSCv36mm8
Celera1621,184,486 - 21,186,549 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.48NCBI
Camk2n2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,226,264 - 23,227,409 (+)Ensembl
ChiLan1.0NW_00495542023,226,270 - 23,227,403 (+)NCBIChiLan1.0ChiLan1.0
CAMK2N2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22182,129,671 - 182,132,010 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13182,134,388 - 182,136,727 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03181,293,755 - 181,296,088 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CAMK2N2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,149,064 - 17,151,371 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3421,235,450 - 21,237,744 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03417,056,765 - 17,059,059 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3417,057,741 - 17,058,854 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13417,094,084 - 17,096,379 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03417,089,948 - 17,092,248 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03417,320,160 - 17,322,454 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Camk2n2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,514,630 - 119,515,996 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365785,606,536 - 5,607,850 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365785,606,507 - 5,607,850 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAMK2N2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,156,041 - 122,158,367 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113122,156,080 - 122,158,396 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,595,849 - 131,598,152 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CAMK2N2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,163,379 - 5,165,676 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,163,600 - 5,164,731 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606313,940,556 - 13,942,901 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Camk2n2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473072,326,904 - 72,328,051 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473072,326,901 - 72,328,073 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Camk2n2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v145,443,970 - 5,446,147 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:108
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000058131
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)119046178196556255Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat

Markers in Region
UniSTS:485633  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,289,708 - 80,290,856 (+)MAPPERmRatBN7.2
Rnor_6.01183,975,437 - 83,976,584NCBIRnor6.0
Rnor_5.01187,047,765 - 87,048,912UniSTSRnor5.0
Cytogenetic Map11q23UniSTS
UniSTS:480474  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,289,684 - 80,290,857 (+)MAPPERmRatBN7.2
Rnor_6.01183,975,413 - 83,976,585NCBIRnor6.0
Rnor_5.01187,047,741 - 87,048,913UniSTSRnor5.0
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 7 48 141 76 75 51 26 51 6 233 99 3 119 65 84 24 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000058131   ⟹   ENSRNOP00000054937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1183,975,367 - 83,976,588 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133442   ⟹   ENSRNOP00000111462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1193,794,095 - 93,795,222 (+)Ensembl
RefSeq Acc Id: NM_021678   ⟹   NP_067710
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,794,095 - 93,795,222 (+)NCBI
mRatBN7.21180,289,702 - 80,290,829 (+)NCBI
Rnor_6.01183,975,430 - 83,976,557 (+)NCBI
Rnor_5.01187,047,758 - 87,048,885 (+)NCBI
RGSC_v3.41182,519,331 - 82,519,584 (+)RGD
Celera1179,129,393 - 79,129,646 (+)RGD
Sequence:
RefSeq Acc Id: XM_063270758   ⟹   XP_063126828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,792,112 - 93,796,153 (+)NCBI
Protein Sequences
Protein RefSeqs NP_067710 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126828 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD02202 (Get FASTA)   NCBI Sequence Viewer  
  EDL78009 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000111462
GenBank Protein Q9Z2N6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_067710   ⟸   NM_021678
- UniProtKB: Q9Z2N6 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054937   ⟸   ENSRNOT00000058131
RefSeq Acc Id: XP_063126828   ⟸   XM_063270758
- Peptide Label: isoform X1
- UniProtKB: Q9Z2N6 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000111462   ⟸   ENSRNOT00000133442

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2N6-F1-model_v2 AlphaFold Q9Z2N6 1-79 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698274
Promoter ID:EPDNEW_R8799
Type:single initiation site
Name:Camk2n2_1
Description:calcium/calmodulin-dependent protein kinase II inhibitor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01183,975,307 - 83,975,367EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708411 AgrOrtholog
BioCyc Gene G2FUF-20743 BioCyc
Ensembl Genes ENSRNOG00000038184 Ensembl
  ENSRNOG00000076327 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000133442 ENTREZGENE
InterPro Camk2n UniProtKB/Swiss-Prot
KEGG Report rno:59314 UniProtKB/Swiss-Prot
NCBI Gene 59314 ENTREZGENE
PANTHER CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II INHIBITOR 2 UniProtKB/Swiss-Prot
  PTHR31007 UniProtKB/Swiss-Prot
Pfam CaM-KIIN UniProtKB/Swiss-Prot
PhenoGen Camk2n2 PhenoGen
RatGTEx ENSRNOG00000038184 RatGTEx
  ENSRNOG00000076327 RatGTEx
UniProt A6JSA3_RAT UniProtKB/TrEMBL
  CK2N2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Camk2n2  calcium/calmodulin-dependent protein kinase II inhibitor 2  LOC59314  CaM-KII inhibitory protein  Symbol and Name updated 1299863 APPROVED
2005-10-07 LOC59314        Symbol and Name status set to provisional 70820 PROVISIONAL