RGD Reference Report - Novel insights into CaMKII function and regulation during memory formation. - Rat Genome Database

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Novel insights into CaMKII function and regulation during memory formation.

Authors: Lucchesi, W  Mizuno, K  Giese, KP 
Citation: Lucchesi W, etal., Brain Res Bull. 2011 Apr 25;85(1-2):2-8. doi: 10.1016/j.brainresbull.2010.10.009. Epub 2010 Nov 9.
RGD ID: 7240706
Pubmed: PMID:21070840   (View Abstract at PubMed)
DOI: DOI:10.1016/j.brainresbull.2010.10.009   (Journal Full-text)

Ca(2+)/calmodulin-dependent kinase II (CaMKII) is an abundant synaptic signalling molecule that is essential for memory formation and the induction of synaptic potentiation. Additionally, CaMKII plays a prominent role in synaptic tagging and metaplasticity. These abilities are mediated by kinase activity as well as binding to a wide variety of synaptic proteins, including NMDA receptor subunits, modulating CaMKII location and activity. A characteristic feature is that autophosphorylation of CaMKII switches the kinase into autonomous activity. Since CaMKII can be autonomously active and because CaMKII is required for the formation of memory it is important that the kinase activity is adequately switched off. However, the exact time window of increased activity and how this is terminated, it is still matter of debate. After training in a memory task CaMKII activity is increased for at least 30 min. This CaMKII activity and further activation of CaMKII may be regulated by changes in the expression of two endogenous CaMKII inhibitor proteins, CaMKII inhibitor Alpha and Beta, as they are up-regulated early after training. These endogenous inhibitors specifically block CaMKII activity and they inhibit the association with NMDA receptor subunits. Thus, regulation of the expression of endogenous CaMKII inhibitors may constitute a novel negative feedback on CaMKII signalling during memory formation.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Camk2n1  (calcium/calmodulin-dependent protein kinase II inhibitor 1)
Camk2n2  (calcium/calmodulin-dependent protein kinase II inhibitor 2)

Genes (Mus musculus)
Camk2n1  (calcium/calmodulin-dependent protein kinase II inhibitor 1)
Camk2n2  (calcium/calmodulin-dependent protein kinase II inhibitor 2)

Genes (Homo sapiens)
CAMK2N1  (calcium/calmodulin dependent protein kinase II inhibitor 1)
CAMK2N2  (calcium/calmodulin dependent protein kinase II inhibitor 2)


Additional Information